Busulfan is a bifunctional alkylating agent, having a selective immunosuppressive effect on bone marrow. It is not a structural analog of the nitrogen mustards. It has been used in the palliative treatment of chronic myeloid leukemia (myeloid leukemia, chronic), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.
For use in combination with cyclophosphamide as a conditioning regimen prior to allogeneic hematopoietic progenitor cell transplantation for chronic myelogenous (myeloid, myelocytic, granulocytic) leukemia (FDA has designated busulfan as an orphan drug for this use). It is also used as a component of pretransplant conditioning regimens in patients undergoing bone marrow transplantation for acute myeloid leukemia and nonmalignant diseases.
University of Texas MD Anderson Cancer Center, Houston, Texas, United States
Pediatric Hematology/Oncology University of Louisville, Louisville, Kentucky, United States
City of Hope Medical Center, Duarte, California, United States
Cleveland Clinic Taussig Cancer Institute, Case Comprehensive Cancer Center, Cleveland, Ohio, United States
Hospital Sor Maria Ludovica, Department Hematology Stem Cell Transplant Unit, La Plata, Argentina
University Hospitals Leuven Kinderhemato-oncologie, Leuven, Belgium
Dana Children's Hospital, Tel Aviv, Israel
St. Jude Children's Research Hospital, Memphis, Tennessee, United States
Mattel Children's Hospital, UCLA, Los Angeles, California, United States
Mark O. Hatfield Clinical Research Center, NIH, Bethesda, Maryland, United States
Rainbow Babies and Childrens Hospital, Cleveland, Ohio, United States
Mattel Children's Hospital UCLA, Los Angeles, California, United States
City of Hope Comprehensive Cancer Center, Duarte, California, United States
M D Anderson Cancer Center, Houston, Texas, United States
Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States
Hospital for Sick Children, Toronto, Ontario, Canada
Memorial Regional Hospital/Joe DiMaggio Children's Hospital, Hollywood, Florida, United States
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