Dextromethorphan

Generic Name: Dextromethorphan

Brand Names: Auvelity, Benylin DM, Bromfed DM, Broncotron, Cepacol Sore Throat Plus Cough, Cheracol D, Children's Nyquil Cold and Cough, Chloraseptic Sore Throat + Cough, Coricidin Hbp Chest Congestion, Coricidin Hbp Cough and Cold, Creomulsion, DM, Dayquil Cough, Delsym, Delsym Cough Plus Chest Congestion DM, Delsym Cough Plus Soothing Action, Delsym Cough Relief Plus Soothing Action, Despec Reformulated Jun 2008, Diabetic Tussin DM, Dimetapp Long Acting Cough Plus Cold, Diphen, G-zyncof, Mucinex Children's Cough, Mucinex Cough, Mucinex DM, Nuedexta, Nyquil Cough, Pediacare Children's Cough and Congestion, Promethazine DM, Robafen Cough, Robafen DM, Robitussin 12 Hour Cough Relief, Robitussin Cough & Congestion, Robitussin Maximum Strength Cough Plus Chest Congestion DM, Robitussin Nighttime Cough DM, Robitussin Pediatric Cough & Cold LA, Robitussin Pediatric Cough Suppressant, Safetussin DM, Safetussin PM, Scot-tussin DM, Scot-tussin Diabetic CF, Scot-tussin Sugar Free DM, Sudafed PE Children's Cold & Cough, Triaminic Day Time Cold & Cough, Tusnel Diabetic

Drug Type: Small Molecule

Chemical Formula: C_₁₈H_₂₅NO

CAS Number: 125-71-3

Unique Ingredient Identifier: 7355X3ROTS

Background: Dextromethorphan is a levorphanol derivative and codeine analog commonly used as a cough suppressant and also a drug of abuse. Although similar in structure to other opioids, it has minimal interaction with opioid receptors.

Dextromethorphan was granted FDA approval before 3 December 1957.

Indication: Dextromethorphan is indicated in combination with brompheniramine and pseudoephedrine in the treatment of coughs and upper respiratory symptoms associated with allergies or the common cold. Dextromethorphan is also used in combination with guaifenesin as an over-the-counter product to relieve a cough. Dextromethorphan in combination with quinidine is indicat...

Associated Conditions: Allergic cough, Common Cold, Cough, Cough caused by Common Cold, Coughing caused by Allergies, Coughing caused by Bronchitis, Coughing caused by Flu caused by Influenza, Fever, Flu caused by Influenza, Headache, Irritative cough, Itching of the nose, Itching of the throat, Major Depressive Disorder (MDD), Nasal Congestion, Pseudobulbar Affect (PBA), Rhinorrhoea, Sneezing, Cold or flu syndrome, Upper respiratory symptoms, Watery itchy eyes

Associated Therapies: Airway secretion clearance therapy, Bronchodilation, Oropharyngeal antisepsis

Clinical Trials

Periarticular Injection Versus Peripheral Nerve Block in Total Hip Arthroplasty

Phase 2

Completed

Conditions: Hip Arthropathy

Interventions: Procedure: Nerve Block
Procedure: Periarticular Injection (PAI)
Drug: Ropivacaine
Drug: Dex

First Posted Date: 2019-06-06

Last Posted Date: 2022-09-23

Lead Sponsor: Yale University

Target Recruit Count: 192

Registration Number: NCT03977454

Locations: 🇺🇸
Yale-New Haven Hospital St Raphael, New Haven, Connecticut, United States

Pharmacokinetic Drug-drug Interaction Study of Encorafenib and Binimetinib on Probe Drugs in Patients With BRAF V600-mutant Melanoma or Other Advanced Solid Tumors

Phase 1

Active, not recruiting

Conditions: Metastatic Melanoma
Advanced Solid Tumors

Interventions: Drug: losartan
Drug: rosuvastatin
Drug: bupropion immediate release (IR)
Drug: dextromethorphan
Drug: caffeine
Drug: modafinil
Drug: omeprazole
Drug: midazolam
Drug: encorafenib
Drug: binimetinib

First Posted Date: 2019-03-06

Last Posted Date: 2023-06-08

Lead Sponsor: Pfizer

Target Recruit Count: 56

Registration Number: NCT03864042

Locations: 🇨🇦
Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
🇺🇸
UC Irvine Health, Orange, California, United States
🇺🇸
University of Colorado Hospital - Anschutz Cancer Pavilion (ACP), Aurora, Colorado, United States

and more 26 locations

Study to Evaluate the Effects of 90 mg Intravenous Infusions of GC4419 on the Single Dose Pharmacokinetics of Dextromethorphan in Healthy Adult Subjects

Phase 1

Completed

Conditions: Healthy

Interventions: Drug: Dextromethorphan HBr
Drug: GC4419

First Posted Date: 2019-01-04

Last Posted Date: 2019-06-19

Lead Sponsor: Galera Therapeutics, Inc.

Target Recruit Count: 13

Registration Number: NCT03792971

Locations: 🇺🇸
Inventiv Health Clinical - Research Pharmacy Unit, Miami, Florida, United States

Drug Interaction Study of CT1812 in Healthy Volunteers

Phase 1

Completed

Conditions: Healthy Volunteers

Interventions: Drug: CT1812
Drug: tolbutamide
Drug: dextromethorphan
Drug: Omeprazole
Drug: midazolam

First Posted Date: 2018-10-23

Last Posted Date: 2018-10-23

Lead Sponsor: Cognition Therapeutics

Target Recruit Count: 16

Registration Number: NCT03716427

Locations: 🇺🇸
Jasper Clinic, Kalamazoo, Michigan, United States

A Pilot Study: a Non-opioid Technique for Postoperative Adenoidectomy Pain Relief in Pediatric Patients

Phase 2

Completed

Conditions: Adenoid Hypertrophy

Interventions: Drug: Dextromethorphan
Drug: Acetaminophen
Drug: Dexmedetomidine
Drug: Ketamine

First Posted Date: 2018-10-22

Last Posted Date: 2021-02-05

Lead Sponsor: Arlyne Thung

Target Recruit Count: 10

Registration Number: NCT03714919

Locations: 🇺🇸
Nationwide Children's Hospital, Columbus, Ohio, United States

Dextromethorphan in Fibromyalgia

Phase 2

Completed

Conditions: Fibromyalgia

Interventions: Drug: Placebo
Drug: Dextromethorphan

First Posted Date: 2018-05-25

Last Posted Date: 2022-08-26

Lead Sponsor: University of Alabama at Birmingham

Target Recruit Count: 27

Registration Number: NCT03538054

Locations: 🇺🇸
University of Alabama of Birmingham, Birmingham, Alabama, United States

Dextromethorphan as a Novel Non-opioid Adjunctive Agent for Pain Control in Medication Abortion

Phase 3

Completed

Conditions: Abortion in First Trimester

Interventions: Drug: Avicel PH101 (Microcrystalline Cellulose NF) for Compounding
Drug: Dextromethorphan Hydrobromide
Drug: Oxycodone

First Posted Date: 2018-03-27

Last Posted Date: 2020-08-06

Lead Sponsor: Study Investigator-Sponsor

Target Recruit Count: 156

Registration Number: NCT03480009

Locations: 🇺🇸
Center for Family Planning Research, Magee-Womens Hospital, Pittsburgh, Pennsylvania, United States
🇺🇸
Planned Parenthood of Western Pennsylvania, Pittsburgh, Pennsylvania, United States