MedPath

Zanamivir

Generic Name
Zanamivir
Brand Names
Relenza, Dectova
Drug Type
Small Molecule
Chemical Formula
C12H20N4O7
CAS Number
139110-80-8
Unique Ingredient Identifier
L6O3XI777I
Background

A guanido-neuraminic acid that is used to inhibit neuraminidase.

Indication

For the prevention and treatment of influenza A and B.

Associated Conditions
Flu caused by Influenza

A Study of Intravenous Zanamivir Versus Oral Oseltamivir in Adults and Adolescents Hospitalized With Influenza

Phase 3
Completed
Conditions
Influenza, Human
Interventions
Drug: Placebo to match zanamivir
Drug: Placebo to match oseltamivir
First Posted Date
2010-11-01
Last Posted Date
2018-10-15
Lead Sponsor
GlaxoSmithKline
Target Recruit Count
626
Registration Number
NCT01231620
Locations
🇬🇧

GSK Investigational Site, Manchester, United Kingdom

Relenza® Sentinel Site Monitoring Program in Japan

Completed
Conditions
Influenza, Human
Interventions
First Posted Date
2010-09-13
Last Posted Date
2017-07-06
Lead Sponsor
GlaxoSmithKline
Target Recruit Count
1575
Registration Number
NCT01199744

Safety Study to Assess IV Zanamivir for Treatment of Influenza Infection in Patients Who Are in Hospital

Phase 2
Completed
Conditions
Influenza, Human
Interventions
First Posted Date
2009-11-17
Last Posted Date
2017-03-28
Lead Sponsor
GlaxoSmithKline
Target Recruit Count
202
Registration Number
NCT01014988
Locations
🇬🇧

GSK Investigational Site, Southampton, United Kingdom

Crossover Study to Investigate the Safety, Tolerability, and Pharmacokinetics of Repeat Dose Zanamivir/Placebo Via Devices Administered Twice Daily for 5 Days

Phase 1
Completed
Conditions
Influenza A Virus, H1N1 Subtype
Interventions
First Posted Date
2009-10-05
Last Posted Date
2017-06-14
Lead Sponsor
GlaxoSmithKline
Target Recruit Count
18
Registration Number
NCT00989404
Locations
🇺🇸

GSK Investigational Site, Minneapolis, Minnesota, United States

Long Term Influenza Prophylaxis With Inhaled Zanamivir or Oral Oseltamivir

Phase 4
Completed
Conditions
Influenza
Interventions
Drug: placebo capsule
Drug: placebo for inhalation
First Posted Date
2009-09-18
Last Posted Date
2010-09-22
Lead Sponsor
University of Oxford
Target Recruit Count
390
Registration Number
NCT00980109
Locations
🇹🇭

Hospital for Tropical Diseases, Bangkok, Thailand

🇹🇭

Faculty of Medicine Siriraj Hospital, Bangkok, Bangkoknoi, Thailand

A Clinical Trial Comparing Oseltamivir With Placebo And Zanamivir With Control As First Line Treatment For Human Swine Influenza Infection

Phase 3
Terminated
Conditions
Upper Respiratory Tract Infection
Influenza
Interventions
First Posted Date
2009-09-18
Last Posted Date
2011-04-11
Lead Sponsor
Chinese University of Hong Kong
Target Recruit Count
4
Registration Number
NCT00979667
Locations
🇭🇰

Sai Ying Pun Jockey Club General Outpatient Clinic, Hong Kong, Hong Kong

🇨🇳

Shau Kei Wan Jockey Club Clinic, Hong Kong, Hong Kong, China

🇭🇰

Fanling Family Medicine Centre, Hong Kong, Hong Kong

Pharmacokinetic Study of Oseltamivir and Intravenous Zanamivir in Healthy Adults

Phase 1
Completed
Conditions
Influenza
Virus Diseases
Interventions
First Posted Date
2009-06-16
Last Posted Date
2010-03-19
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Target Recruit Count
17
Registration Number
NCT00921726
Locations
🇹🇭

Mathidol University, Salaya, Thailand

TCAD vs. Monotherapy for Influenza A in Immunocompromised Patients

Phase 1
Completed
Conditions
Influenza
Interventions
Drug: TCAD
Other: Open label treatment with TCAD
First Posted Date
2009-03-23
Last Posted Date
2013-08-15
Lead Sponsor
Fred Hutchinson Cancer Center
Target Recruit Count
7
Registration Number
NCT00867139
Locations
🇺🇸

Seattle Children's, Seattle, Washington, United States

🇺🇸

Fred Hutchinson Cancer Research Center, Seattle, Washington, United States

Zanamivir Versus Trivalent Split Virus Influenza Vaccine

Phase 3
Completed
Conditions
Influenza
Interventions
Biological: Fluviral
First Posted Date
2008-11-04
Last Posted Date
2014-11-21
Lead Sponsor
Mount Sinai Hospital, Canada
Target Recruit Count
64
Registration Number
NCT00784784
Locations
🇨🇦

Mount Sinai Hospital, Toronto, Ontario, Canada

© Copyright 2025. All Rights Reserved by MedPath