Nicotine

Generic Name: Nicotine

Brand Names: Habitrol, Nicoderm C-Q, Nicorelief, Nicorette, Nicotrol

Drug Type: Small Molecule

Chemical Formula: C_₁₀H_₁₄N_₂

CAS Number: 54-11-5

Unique Ingredient Identifier: 6M3C89ZY6R

Background: Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke.

Indication: For the relief of nicotine withdrawal symptoms and as an aid to smoking cessation.

Associated Conditions: Withdrawal Nicotine

Associated Therapies: Smoking cessation therapy

Clinical Trials

Flavors and E-cigarette Effects in Adolescent Smokers- STUDY 1

Phase 1

Completed

Conditions: Nicotine Dependence, Other Tobacco Product

Interventions: Drug: Nicotine
Other: Low Dose Menthol
Other: High Dose Menthol

First Posted Date: 2014-07-01

Last Posted Date: 2020-05-04

Lead Sponsor: Yale University

Target Recruit Count: 59

Registration Number: NCT02179034

Locations: 🇺🇸
CMHC, New Haven, Connecticut, United States

Electronic Cigarettes in Daily Dependent Smokers

Phase 4

Completed

Conditions: Substance Withdrawal Syndrome
Nicotine Dependence

Interventions: Drug: Nicotine
Drug: Placebo

First Posted Date: 2014-04-09

Last Posted Date: 2015-05-05

Lead Sponsor: Centre for Addiction and Mental Health

Target Recruit Count: 43

Registration Number: NCT02108626

Locations: 🇨🇦
Centre for Addiction and Mental Health, BACDRL Lab, Toronto, Ontario, Canada

The Effects of Menthol as Delivered by an Electronic Cigarette on the Desirability of Nicotine in Tobacco Users

Not Applicable

Completed

Conditions: Nicotine Dependence

Interventions: Drug: nicotine
Drug: menthol

First Posted Date: 2014-04-02

Last Posted Date: 2020-03-19

Lead Sponsor: Yale University

Target Recruit Count: 57

Registration Number: NCT02102100

Locations: 🇺🇸
Connecticut VA Healthcare System, West Haven, Connecticut, United States
🇺🇸
VA Connecticut Health Care System, West Haven, Connecticut, United States

Validation of a Remote Wireless Sensor Network (WSN) Approach to the Individualized Detection of Cocaine Use in Humans

Phase 1

Completed

Conditions: Cocaine Dependence

Interventions: Drug: Cocaine hydrochloride
Behavioral: Exercise
Drug: Nicotine

First Posted Date: 2013-12-23

Last Posted Date: 2023-02-16

Lead Sponsor: Yale University

Target Recruit Count: 5

Registration Number: NCT02018263

Locations: 🇺🇸
Connecticut Mental Health Center, New Haven, Connecticut, United States

Very Low-Nicotine Cigarettes in Smokers With SUD

Phase 2

Completed

Conditions: Nicotine Dependence

Interventions: Drug: Nicotine
Behavioral: behavioral counseling for smoking cessation

First Posted Date: 2013-11-21

Last Posted Date: 2021-09-28

Lead Sponsor: Brown University

Target Recruit Count: 250

Registration Number: NCT01989507

Locations: 🇺🇸
Brown University's Center for Alcohol and Addiction Studies, Providence, Rhode Island, United States

Preliminary Investigation of Novel Methods to Reduce Children's Secondhand Smoke Exposure

Not Applicable

Completed

Conditions: Secondhand Smoke

Interventions: Drug: Dissolvable Tobacco Lozenge
Drug: Electronic Cigarette
Drug: Nicotine polacrilex

First Posted Date: 2013-09-05

Last Posted Date: 2024-02-28

Lead Sponsor: University of Oklahoma

Target Recruit Count: 89

Registration Number: NCT01935713

Locations: 🇺🇸
The Children's Hospital at OU Medical Center, Oklahoma City, Oklahoma, United States

e-Cigarettes Versus NRT Gum for Smoking Cessation

Phase 4

Terminated

Conditions: Nicotine Addiction
Smoking Cessation

Interventions: Other: STAM 1100mAh CE4 eGo Clearomizer
Drug: Nicotine polacrilex

First Posted Date: 2013-08-20

Last Posted Date: 2016-01-14

Lead Sponsor: Creighton University

Target Recruit Count: 10

Registration Number: NCT01925781

Locations: 🇺🇸
Creighton University, Omaha, Nebraska, United States

Novel Methods to Reduce Children's Secondhand Smoke Exposure II

Not Applicable

Completed

Conditions: Secondhand Smoke

Interventions: Drug: Tobacco lozenge
Drug: Nicotine polacrilex

First Posted Date: 2013-07-11

Last Posted Date: 2018-03-15

Lead Sponsor: University of Oklahoma

Target Recruit Count: 74

Registration Number: NCT01896518

Locations: 🇺🇸
The Children's Hospital at OU Medical Center, Oklahoma City, Oklahoma, United States

A Cost-effectiveness Study of Nicotine Patches Distributed Through a Quitline

Not Applicable

Completed

Conditions: Smoking Cessation

Interventions: Drug: Nicotine Patch

First Posted Date: 2013-06-28

Last Posted Date: 2016-02-11

Lead Sponsor: University of Colorado, Denver

Target Recruit Count: 1495

Registration Number: NCT01889771

Acute and Chronic Nicotine Modulation of Reinforcement Learning

Not Applicable

Completed

Conditions: Nicotine Addiction

Interventions: Other: satiety
Drug: Nicotine polacrilex
Other: abstinence
Drug: Placebo

First Posted Date: 2013-04-12

Last Posted Date: 2017-12-19

Lead Sponsor: Duke University

Target Recruit Count: 54

Registration Number: NCT01830842

Locations: 🇺🇸
Duke University, Durham, North Carolina, United States

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