MedPath

Nicotine

Generic Name
Nicotine
Brand Names
Habitrol, Nicoderm C-Q, Nicorelief, Nicorette, Nicotrol
Drug Type
Small Molecule
Chemical Formula
C10H14N2
CAS Number
54-11-5
Unique Ingredient Identifier
6M3C89ZY6R
Background

Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke.

Indication

For the relief of nicotine withdrawal symptoms and as an aid to smoking cessation.

Associated Conditions
Withdrawal Nicotine
Associated Therapies
Smoking cessation therapy
Clinical Trials
Related News

Sensitivity to Intravenous Nicotine: Genetic Moderators

Phase 1
Completed
Conditions
Nicotine Dependence
Interventions
Drug: saline
Drug: Nicotine
First Posted Date
2009-09-01
Last Posted Date
2017-04-19
Lead Sponsor
Yale University
Target Recruit Count
213
Registration Number
NCT00969137
Locations
🇺🇸

Department of Veterans Affairs, West Haven, Connecticut, United States

Study of NP002 in Subjects With Idiopathic Parkinson's Disease to Treat Dyskinesias Due to Levodopa Therapy

Phase 1
Completed
Conditions
Parkinson's Disease
Interventions
Other: placebo comparator
Drug: nicotine
First Posted Date
2009-08-13
Last Posted Date
2011-10-05
Lead Sponsor
Neuraltus Pharmaceuticals, Inc.
Target Recruit Count
65
Registration Number
NCT00957918
Locations
🇺🇸

Strurers Parkinson's Center, Golden Valley, Minnesota, United States

🇺🇸

Barrow Neurology Clinics at St. Joseph's Hospital and Medical Center, Phoenix, Arizona, United States

🇺🇸

Keck/USC School of Medicine -Department of Neurology, Los Angelis, California, United States

and more 9 locations

Efficacy and Safety Following Use of a Novel Nicotine Replacement Therapy

Not Applicable
Completed
Conditions
Smoking Cessation
Interventions
Drug: Placebo
Drug: Nicotine
First Posted Date
2009-04-16
Last Posted Date
2012-07-02
Lead Sponsor
McNeil AB
Target Recruit Count
479
Registration Number
NCT00882375
Locations
🇩🇰

Gentofte University Hospital, Hellerup, Denmark

🇩🇪

University of Heidelberg, Mannheim, Germany

🇩🇪

University Hospital of Tuebingen, Tuebingen, Germany

Efficacy of Transdermal Nicotine, on Motor Symptoms in Advanced Parkinson's Disease

Phase 2
Completed
Conditions
Idiopathic Parkinson's Disease
Interventions
Drug: Transdermal nicotine
Other: Usual drug treatment of Parkinson's disease
First Posted Date
2009-04-01
Last Posted Date
2013-12-31
Lead Sponsor
Assistance Publique - Hôpitaux de Paris
Target Recruit Count
40
Registration Number
NCT00873392
Locations
🇫🇷

Groupe Hospitalier Albert Chenevier Henri Mondor, Creteil, France

Varenicline or Nicotine Patch and Nicotine Gum in Helping Smokers in a Methadone Treatment Program Stop Smoking

Not Applicable
Completed
Conditions
Bladder Cancer
Cervical Cancer
Esophageal Cancer
Gastric Cancer
Head and Neck Cancer
Kidney Cancer
Leukemia
Liver Cancer
Lung Cancer
Pancreatic Cancer
Interventions
Other: placebo
Drug: varenicline
Drug: nicotine
First Posted Date
2008-11-13
Last Posted Date
2018-06-06
Lead Sponsor
Butler Hospital
Target Recruit Count
315
Registration Number
NCT00790569
Locations
🇺🇸

Rhode Island Hospital Comprehensive Cancer Center, Providence, Rhode Island, United States

Clinical Study of Smoke-Break Liquid Cigarettes

Phase 2
Completed
Conditions
Smoking
Interventions
Drug: Nicotine
Device: Smoke-Break nicotine delivery device
First Posted Date
2008-07-15
Last Posted Date
2014-11-19
Lead Sponsor
Smoke-Break, Inc.
Target Recruit Count
52
Registration Number
NCT00715871
Locations
🇺🇸

Tommy G. Thompson Youth Center, West Allis, Wisconsin, United States

Nicotinic Modulation of Schizophrenia-like Information Processing Deficits in Healthy Subjects

Phase 1
Completed
Conditions
Healthy Subjects
Interventions
Drug: Ketamine and Nicotine
Drug: Placebo
Drug: Nicotine
Drug: Ketamine
First Posted Date
2008-06-04
Last Posted Date
2012-05-09
Lead Sponsor
Yale University
Target Recruit Count
30
Registration Number
NCT00690170
Locations
🇺🇸

Veterans Administration Hospital, West Haven, Connecticut, United States

Oral Tolerability Of Two Nicotine Dosage Forms

Phase 1
Completed
Conditions
Healthy Volunteer Smokers
Interventions
Drug: Nicotine
First Posted Date
2008-05-22
Last Posted Date
2013-03-01
Lead Sponsor
GlaxoSmithKline
Target Recruit Count
200
Registration Number
NCT00682461

Functional Magnetic Resonance Imaging (fMRI) Investigation of Nicotine Withdrawal Symptoms

Phase 4
Completed
Conditions
Smoking
Interventions
Drug: Nicotine
Drug: Placebo
First Posted Date
2008-04-14
Last Posted Date
2015-03-02
Lead Sponsor
GlaxoSmithKline
Target Recruit Count
23
Registration Number
NCT00657020

Nicotine Patch Pretreatment for Smoking Cessation in PTSD

Early Phase 1
Completed
Conditions
Tobacco Use Disorder
Stress Disorders, Posttraumatic
Interventions
Behavioral: Cognitive Behavioral Therapy for Smoking Cessation
Drug: Nicotine
Drug: Placebo patch
Drug: Bupropion Sustained Release (SR)
First Posted Date
2008-02-28
Last Posted Date
2014-11-20
Lead Sponsor
US Department of Veterans Affairs
Target Recruit Count
87
Registration Number
NCT00625131
Locations
🇺🇸

VA Medical Center, Durham, Durham, North Carolina, United States

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