Aminoglutethimide
- Generic Name
- Aminoglutethimide
- Drug Type
- Small Molecule
- Chemical Formula
- C13H16N2O2
- CAS Number
- 125-84-8
- Unique Ingredient Identifier
- 0O54ZQ14I9
- Background
An aromatase inhibitor that produces a state of "medical" adrenalectomy by blocking the production of adrenal steroids. It also blocks the conversion of androgens to estrogens. Aminoglutethimide has been used in the treatment of advanced breast and prostate cancer. It was formerly used for its weak anticonvulsant properties. (From Martindale, The Extra Pharmacopoeia, 30th ed, p454)
- Indication
For the suppression of adrenal function in selected patients with Cushing's syndrome, malignant neoplasm of the female breast, and carcinoma in situ of the breast.
PRIMUS002: Looking at 2 Neo-adjuvant Treatment Regimens for Resectable and Borderline Resectable Pancreatic Cancer
- First Posted Date
- 2019-11-26
- Last Posted Date
- 2022-05-24
- Lead Sponsor
- Judith Dixon-Hughes
- Target Recruit Count
- 31
- Registration Number
- NCT04176952
- Locations
- 🇬🇧
Western General, Edinburgh, United Kingdom
🇬🇧Beatson West of Scotland Cancer Centre, Glasgow, United Kingdom
🇬🇧Royal Free Hospital, London, United Kingdom
Sequential Use of AG and mFOLFIRINOX as Neoadjuvant Chemotherapy for Resectable Pancreatic Cancer
- Conditions
- Pancreatic Adenocarcinoma ResectableNeoadjuvant Chemotherapy
- Interventions
- Drug: mFolfirinox
- First Posted Date
- 2018-11-23
- Last Posted Date
- 2025-05-13
- Lead Sponsor
- Second Affiliated Hospital, School of Medicine, Zhejiang University
- Target Recruit Count
- 324
- Registration Number
- NCT03750669
- Locations
- 🇨🇳
The second affiliated hospital of Zhejiang University, Hangzhou, Zhejiang, China
Therapeutic Confirmatory Clinical Trial to Evaluate the Safety and Efficacy of "AG NPP709 Syrup"
- Conditions
- Acute Upper Respiratory Tract InfectionsBronchitis
- Interventions
- First Posted Date
- 2010-06-28
- Last Posted Date
- 2010-10-05
- Lead Sponsor
- Ahn-Gook Pharmaceuticals Co.,Ltd
- Target Recruit Count
- 236
- Registration Number
- NCT01151202
- Locations
- 🇰🇷
Hanyang University Medical Center, Department of Respiratory Medicine, Seoul, Korea, Republic of
🇰🇷Inha University Hospital, Department of Pediatrics, Incheon, Korea, Republic of
🇰🇷Kyung Hee University International Medical Service, Department of Pediatrics, Seoul, Korea, Republic of
Treatment for Patients With Metastatic Thyroid Cancer
- First Posted Date
- 2005-09-15
- Last Posted Date
- 2010-01-15
- Lead Sponsor
- University of Michigan Rogel Cancer Center
- Target Recruit Count
- 3
- Registration Number
- NCT00176748
- Locations
- 🇺🇸
University of Michigan Cancer Center, Ann Arbor, Michigan, United States
A Phase II Trial of Early Medical Adrenalectomy for "D0.5" Prostate Cancer
- Conditions
- Prostate Cancer
- Interventions
- First Posted Date
- 2004-04-02
- Last Posted Date
- 2012-09-27
- Target Recruit Count
- 2
- Registration Number
- NCT00006371
- Locations
- 🇺🇸
H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States
Drug Development Updates
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