A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.
For use in combination with other chemotherapeutic agents in the treatment of refractory testicular tumors and as first line treatment in patients with small cell lung cancer. Also used to treat other malignancies such as lymphoma, non-lymphocytic leukemia, and glioblastoma multiforme.
City of Hope Medical Center, Duarte, California, United States
Research Site, Taipei City, Taiwan
Universitätsklinikum Jena, Jena, Germany
Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany
DIAKO Ev.Diakonie-Krankenhaus gemeinnützige GmbH, Bremen, Germany
Indiana University Melvin & Bren Simon Cancer Center, Indianapolis, Indiana, United States
Ohio State University Comprehensive Cancer Center, Columbus, Ohio, United States
Memorial Hospital East, Shiloh, Illinois, United States
University of Pennsylvania/Abramson Cancer Center, Philadelphia, Pennsylvania, United States
Cedars-Sinai Medical Center, Samuel Oschin Comprehensive Cancer Institute, Los Angeles, California, United States
Swedish Cancer Institute, Seattle, Washington, United States
USC/Norris Comprehensive Cancer Center, Los Angeles, California, United States
Research Site, Pamukkale, Turkey
Cross Cancer Institute, Edmonton, Alberta, Canada
Research Site, Valencia, Spain
Affiliated Hospital Of Jiangnan University, Wuxi, Jiangsu, China
The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning, China
Shandong Cancer Hospital, Jinan, Shandong, China
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