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Articaine

Generic Name: Articaine

Brand Names: Articadent, Astracaine, Orabloc, Septanest, Septocaine, Ultacan, Ultracaine, Zorcaine

Drug Type: Small Molecule

Chemical Formula: C_₁₃H_₂₀N_₂O_₃S

CAS Number: 23964-58-1

Unique Ingredient Identifier: D3SQ406G9X

Overview

Articaine is a dental local anesthetic. Articaine is widely used around the world and is the most popular local anesthetic in many European countries.

Indication

适用于牙槽外科、牙髓治疗、牙体预备级黏膜切开等口腔手术麻醉。

Associated Conditions

No associated conditions information available.

Clinical Trials

Title	Posted	Study ID	Phase	Status	Sponsor
Effects of Local Ketamine in Orthognathic Procedures	2025/07/15	NCT07066306	Not Applicable	Active, not recruiting	Bezmialem Vakif University
Pain After Buffered Vs Non Buffered Articaine	2024/08/05	NCT06538233	Phase 2	Recruiting	Cleveland Dental Institute
Articaine Plus Dexmedetomidine in Supraclavicular Block	2024/05/21	NCT06423859	Not Applicable	Recruiting	Benha University
The Effectiveness of Buccal Infiltration Only Using Articaine for Extraction of Mandibular Molar	2023/12/08	NCT06161714	Phase 4	Not yet recruiting	Riyadh Elm University
Combination of Buffered Anesthetic to Treat Mandibular Molars	2023/09/21	NCT06047366	Phase 4	Terminated	Indiana University
Comparative Effect of Palatal Injection in Pediatric Patient	2023/09/06	NCT06025825	N/A	Recruiting	Ankara Yildirim Beyazıt University
Articaine Efficiency in Pulpectomy of Children With Irreversible Pulpitis Under the Age of Four	2023/07/13	NCT05944341	Not Applicable	Recruiting	Minia University
Different Volumes of Articaine for Inferior Alveolar Nerve Block in Irreversible Pulpitis	2023/05/03	NCT05840913	Phase 2	Completed	Armed Forces Institute of Dentistry, Pakistan
Articaine Efficacy and Safety for 3 Years Old Children	2023/05/03	NCT05839548	Phase 3	Active, not recruiting	Qassim Health Cluster
Comparing General Anesthesia With Single Injection Peribulbar Block With 3 Different Drugs	2023/02/14	NCT05728151	Not Applicable	Completed	Research Institute of Ophthalmology, Egypt

FDA Drug Approvals

Approved Product	Manufacturer	NDC Code	Route	Strength	Effective Date
Articaine Hydrochloride and Epinephrine	Midway Dental Supply, LLC	72304-016	SUBMUCOSAL	40 mg in 1 mL	12/12/2022
Articaine Hydrochloride and Epinephrine	Henry Schein	0404-6620	SUBMUCOSAL	40 mg in 1 mL	3/1/2024
Articaine Hydrochloride and Epinephrine	Midway Dental Supply, LLC	72304-015	SUBMUCOSAL	40 mg in 1 mL	12/12/2022
ARTICAINE	Patterson Dental	50227-1050	SUBMUCOSAL	40 mg in 1 mL	3/6/2024
Articaine HCl and Epinephrine	Safco Dental Supply Co.	67239-0210	SUBMUCOSAL	40 mg in 1 mL	1/18/2023
ARTICAINE	NDC, Inc.	43128-101	SUBMUCOSAL	40 mg in 1 mL	3/6/2024
Articaine Hydrochloride and Epinephrine	Burkhart Dental Supply Co., Inc	43498-816	SUBMUCOSAL	40 mg in 1 mL	2/7/2024
ARTICAINE	NDC, Inc.	43128-102	SUBMUCOSAL	40 mg in 1 mL	3/6/2024
Orabloc	Pierrel S.p.A.	45146-110	SUBMUCOSAL	40 mg in 1 mL	7/23/2016
Articaine Hydrochloride and Epinephrine	Burkhart Dental Supply Co., Inc	43498-993	SUBMUCOSAL	40 mg in 1 mL	2/7/2024

EMA Drug Approvals

Approved Product	Authorization Holder	Status	Issued Date
No EMA approvals found for this drug.

HSA Drug Approvals

Approved Product	Manufacturer	Approval Number	Dosage Form	Strength	Approval Date
UBISTESIN INJECTION	3M Deutschland GmbH	SIN05504P	INJECTION	40 mg/ml	2/26/1991
ARTINIBSA 4% WITH EPINEPHRINE SOLUTION FOR INJECTION 1:100000	Laboratorios Inibsa, S.A.	SIN15913P	INJECTION, SOLUTION	40.00 mg	3/18/2020
UBISTESIN FORTE INJECTION	3M Deutschland GmbH	SIN05505P	INJECTION	40 mg/ml	2/26/1991
CITOCARTIN 100 INJECTION 1.7 ml/cartridge	LABORATORIOS NORMON, S.A.	SIN12648P	INJECTION	40 mg/ml	3/7/2005
Posicaine-100 Injection	Novocol Pharmaceutical of Canada Inc.	SIN14537P	INJECTION, SOLUTION	40mg/ml	4/10/2014

NMPA Drug Approvals

Approved Product	Company	Approval Number	Drug Type	Dosage Form	Approval Date
No NMPA approvals found for this drug.

PPB Drug Approvals

Approved Product	Registration No.	Company	Licence No.	Strength	Registration Date
SEPTANEST WITH ADRENALINE INJ 1/100,000	N/A	Horseley	N/A	N/A	12/30/2009

TGA Drug Approvals

Approved Product	ARTG ID	Sponsor	Registration Type	Status	Registration Date
SEPTANEST 1:200,000 articaine HCl 4% with adrenaline 1:200,000, solution for injection 1.7 ml cartridge	261413	Specialites Septodont Pty Ltd	Medicine	A	10/7/2016
4% Articadent DENTAL with adrenaline (epinephrine) 1:100,000 articaine hydrochloride and adrenaline (epinephrine) 2.2 mL injection cartridge	231745	Dentsply Sirona Pty Ltd	Medicine	A	10/22/2015
UBISTESIN articaine HCl 4% with adrenaline (epinephrine) 1:200,000 solution for injection cartridge	165573	Independent Dental Supplies Pty Ltd	Medicine	A	6/6/2011
DELTAZINE 1:100,000 articaine hydrochloride and adrenaline (epinephrine) 1.7mL solution for injection - cartridge	101551	Specialites Septodont Pty Ltd	Medicine	A	5/21/2004
UBISTESIN FORTE articaine HCl 4% with adrenaline (epinephrine) 1:100,000 solution for injection cartridge	165574	Independent Dental Supplies Pty Ltd	Medicine	A	6/6/2011
SEPTANEST 1:100,000 articaine hydrochloride and adrenaline (epinephrine) 2.2mL solution for injection - cartridge	101545	Specialites Septodont Pty Ltd	Medicine	A	5/21/2004
DELTAZINE 1:200,000 articaine HCl 4% with adrenaline 1:200,000, solution for injection 1.7 ml cartridge	271233	Specialites Septodont Pty Ltd	Medicine	A	10/7/2016
DELTAZINE 1:100,000 articaine hydrochloride and adrenaline (epinephrine) 2.2mL solution for injection - cartridge	101552	Specialites Septodont Pty Ltd	Medicine	A	5/21/2004
SEPTANEST 1:200,000 articaine HCl 4% with adrenaline 1:200,000, solution for injection 2.2 mL cartridge	271232	Specialites Septodont Pty Ltd	Medicine	A	10/7/2016
SEPTANEST 1:100,000 articaine hydrochloride and adrenaline (epinephrine) 1.7mL solution for injection - cartridge	101544	Specialites Septodont Pty Ltd	Medicine	A	5/21/2004

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