Lumefantrine
- Generic Name
- Lumefantrine
- Brand Names
- Coartem
- Drug Type
- Small Molecule
- Chemical Formula
- C30H32Cl3NO
- CAS Number
- 82186-77-4
- Unique Ingredient Identifier
- F38R0JR742
- Background
Lumefantrine is an antimalarial agent used to treat acute uncomplicated malaria. It is administered in combination with artemether for improved efficacy. This combination therapy exerts its effects against the erythrocytic stages of Plasmodium spp. and may be used to treat infections caused by P. falciparum and unidentified Plasmodium species, including infections acquired in chloroquine-resistant areas.
- Indication
Lumefantrine and artemether combination therapy is indicated for the treatment of acute uncomplicated malaria caused by Plasmodium falciparum, including malaria acquired in chloroquine-resistant areas. May also be used to treat uncomplicated malaria when the Plasmodium species has not been identified. Indicated for use in adults and children greater than 5 kg.
- Associated Conditions
- Uncomplicated Malaria caused by Plasmodium falciparum
ACT MALI: Treatment of Malaria Based on Combination Therapies
- Conditions
- Malaria
- Interventions
- First Posted Date
- 2007-03-28
- Last Posted Date
- 2010-02-17
- Lead Sponsor
- Sanofi
- Target Recruit Count
- 780
- Registration Number
- NCT00452907
- Locations
- 🇲🇱
Sanofi-Aventis Administrative Office, Bougoula, Mali
Pyronaridine Artesunate (3:1) Versus Coartem® in P Falciparum Malaria Patients
- Conditions
- Malaria
- Interventions
- First Posted Date
- 2007-01-15
- Last Posted Date
- 2021-11-02
- Lead Sponsor
- Medicines for Malaria Venture
- Target Recruit Count
- 1272
- Registration Number
- NCT00422084
- Locations
- 🇨🇩
Ecole de Santé Publique, Faculté de Médecine, Université de Kinshasa, Kinshasa, Congo, The Democratic Republic of the
🇬🇲Farafenni Field Station, c/o: MRC Laboratories, Fajara, Gambia
🇬🇭Komfo Anoykye Teaching Hospital, Kumasi, Ghana
Efficacy of Sulphadoxine-pyrimethamine and Artemisinin-containing Combination Therapy for Malaria
- Conditions
- Malaria (Uncomplicated)
- First Posted Date
- 2005-09-01
- Last Posted Date
- 2012-09-11
- Lead Sponsor
- Centers for Disease Control and Prevention
- Target Recruit Count
- 390
- Registration Number
- NCT00140361
- Locations
- 🇹🇿
Ngere Ngere Health Center, Ngere Ngere, Morogoro Rural, Tanzania
🇹🇿Ikwiriri Health Center, Ikwiriri, Rufiji, Tanzania
🇹🇿Lupiro Health Center, Lupiro, Ulanga, Tanzania
Kintampo Trial of Combination Therapy for Malaria
- Conditions
- Malaria
- First Posted Date
- 2005-07-13
- Last Posted Date
- 2017-01-12
- Lead Sponsor
- London School of Hygiene and Tropical Medicine
- Target Recruit Count
- 510
- Registration Number
- NCT00119145
- Locations
- 🇬🇭
Kintampo Health Research Centre, Kintampo, Brong Ahafo Region, Ghana
Drug Development Updates
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