Coenzyme M
- Generic Name
- Coenzyme M
- Brand Names
- Uromitexan
- Drug Type
- Small Molecule
- Chemical Formula
- C2H6O3S2
- CAS Number
- 3375-50-6
- Unique Ingredient Identifier
- VHD28S0H7F
- Background
Coenzyme M (commonly known by its salt form, Mesna) is a synthetic sulfhydryl (thiol) compound and is used for prophylaxis of Ifosfamide and cyclophosphamide induced hemorrhagic cystitis.
- Indication
Mesna is a uroprotective agent and is used prophylactically to reduce ifosfamide and cyclophosphamide induced hemorrhagic cystitis.
- Associated Conditions
- Hemorrhagic cystitis caused by cyclophosphamide, Hemorrhagic cystitis caused by ifosfamide
Spur Therapeutics' FLT201 Gene Therapy Shows Promise in Gaucher Disease with FDA Alignment on Phase 3
• Spur Therapeutics' FLT201, a gene therapy for Gaucher disease, demonstrated positive Phase 1/2 results, showing durable reductions in lyso-Gb1 and a favorable safety profile.
• The FDA has aligned with Spur on a single-arm Phase 3 study design for FLT201, potentially supporting accelerated approval based on lyso-Gb1 reductions.
• The Phase 3 trial will assess maintenance or improvement in hemoglobin levels, a key endpoint for full approval, with the first patient expected to be dosed in H2 2025.
• FLT201 leverages an AAVS3 capsid to deliver a longer-acting version of the deficient enzyme, aiming to reduce treatment burden for Gaucher disease patients.
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