Prednisolone

Generic Name: Prednisolone

Brand Names: Millipred Dp 6 Day

Drug Type: Small Molecule

Chemical Formula: C_₂₁H_₂₈O_₅

CAS Number: 50-24-8

Unique Ingredient Identifier: 9PHQ9Y1OLM

Background: Prednisolone is a glucocorticoid similar to cortisol used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects.

Prednisolone was granted FDA approval on 21 June 1955.

Indication: Prednisolone is indicated to treat endocrine, rheumatic, and hematologic disorders; collagen, dermatologic, ophthalmic, respiratory, and gastrointestinal diseases; allergic and edematous states; and other conditions like tuberculous meningitis.

Associated Conditions: Acute Gouty Arthritis, Acute Leukemia, Allergic Bronchopulmonary Aspergillosis, Allergic Conjunctivitis (AC), Allergic Contact Dermatitis, Allergic Skin Reaction, Allergic corneal marginal ulcers, Alveolitis, Extrinsic Allergic, Ankylosing Spondylitis (AS), Aspiration Pneumonia, Aspiration Pneumonitis, Atopic Dermatitis, Bell's Palsy, Berylliosis, Bullous dermatitis herpetiformis, Burns, Chorioretinitis, Choroiditis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Conjunctivitis, Contact Dermatitis, Corneal injuries, Corneal ulceration, Crohn's Disease (CD), Cyclitis, Dermatomyositis (DM), Dermatosis of the Ear Canal, Drug hypersensitivity reaction, Edema of the cerebrum, Epicondylitis, Erythroblastopenia, Exacerbation of COPD, Exacerbation of asthma, Eye inflammation caused by Cataract Surgery, Eye inflammation caused by Infection, Fissure;Anal, Herpes Zoster Keratitis, Hot Water Burns (Scalds), Hypercalcemia of Malignancy, Idiopathic Pulmonary Fibrosis (IPF), Immune Thrombocytopenia (ITP), Inflamed External Hemorrhoid, Inflamed Hemorrhoids, Internal, Inflammatory Reaction caused by susceptible Bacterial Infections, Iridocyclitis, Iritis, Itching caused by susceptible Bacterial Infections, Keratitis, Loeffler's syndrome, Lymphoma, Metastatic Castration-Resistant Prostate Cancer (mCRPC), Multiple sclerosis exacerbation, Mycosis Fungoides (MF), Ocular Inflammation, Ophthalmia, Sympathetic, Optic Neuritis, Otic Eczema, Pemphigus, Perennial Allergic Rhinitis (PAR), Pericarditis, Pneumocystis Jirovecii Pneumonia, Polymyalgia Rheumatica (PMR), Posterior Uveitis, Posttraumatic Osteoarthritis, Proctitis, Proteinuria, Pruritus, Pruritus Ani, Psoriatic Arthritis, Pulmonary Tuberculosis (TB), Pure Red Cell Aplasia, Rash, Relapsing Polychondritis, Rheumatoid Arthritis, Rheumatoid Arthritis, Juvenile, Rosacea, Seasonal Allergic Rhinitis, Secondary Adrenal Insufficiency, Secondary thrombocytopenia, Serum Sickness, Severe Asthma, Sjogren's Syndrome (SS), Stevens-Johnson Syndrome, Superficial punctate keratitis, Synovitis, Systemic Lupus Erythematosus, Transplanted Organ Rejection, Trichinosis, Tuberculosis (TB), Tuberculous Meningitis, Ulcerative Colitis, Uveitis, Vasculitis, Acquired immune hemolytic anemia, Acute Bursitis, Acute Rheumatic heart disease, unspecified, Acute Tenosynovitis, Anal eczema, Bacterial skin infections, Exfoliative erythroderma, Idiopathic Bronchiolitis obliterans with organizing pneumonia, Idiopathic eosinophilic pneumonias, Non-suppurative Thyroiditis, Primary adrenocoritical insufficiency, Severe Psoriasis, Severe Seborrhoeic dermatitis, Severe alcoholic liver disease, Steroid-responsive inflammation of the eye, Subacute Bursitis, Susceptible Bacterial Infections, Symptomatic Sarcoidosis, Varicella-zoster virus acute retinal necrosis

Associated Therapies: -

Clinical Trials

Top-down Infliximab Study in Kids With Crohn's Disease

Phase 4

Completed

Conditions: Crohn's Disease

Interventions: Drug: Prednisolone
Drug: Infliximab
Other: Exclusive enteral nutrition
Drug: Azathioprine

First Posted Date: 2015-08-07

Last Posted Date: 2024-03-05

Lead Sponsor: Erasmus Medical Center

Target Recruit Count: 100

Registration Number: NCT02517684

Locations: 🇳🇱
Academic Medical Center, Amsterdam, Netherlands
🇳🇱
Amphia Hospital, Breda, Netherlands
🇳🇱
Radboud University Medical Center, Nijmegen, Netherlands

and more 10 locations

A Single Ascending Dose Study To Assess The Safety, Tolerability, Pharmacokinetics And Pharmacodynamics Of AZD9567.

Phase 1

Completed

Conditions: Tolerability
Safety
Pharmacokinetics
Pharmacodynamics
Healthy Subjects
Rheumatoid Arthritis

Interventions: Drug: AZD9567 Monohydrat
Drug: Placebo oral suspension/ Placebo capsule
Drug: Prednisolone

First Posted Date: 2015-07-31

Last Posted Date: 2018-10-04

Lead Sponsor: AstraZeneca

Target Recruit Count: 72

Registration Number: NCT02512575

Locations: 🇩🇪
Research Site, Berlin, Germany

Combination of Cabazitaxel With Prednisolone With Primary Prophylaxis With PEG-G-CSF in Treatment of Patients With Prostate Cancer

Phase 4

Completed

Conditions: Prostate Cancer

Interventions: Drug: CABAZITAXEL XRP6258
Drug: PEG-G-CSF
Drug: Prednisolone
Drug: Dexchlorpheniramine or Diphenhydramine
Drug: Ranitidine
Drug: Metoclopramide, Granisetron, or Ondansetron
Drug: Dexamethasone

First Posted Date: 2015-05-12

Last Posted Date: 2017-01-24

Lead Sponsor: Sanofi

Target Recruit Count: 21

Registration Number: NCT02441894

Locations: 🇯🇵
Investigational Site Number 392008, Kita-gun, Japan
🇯🇵
Investigational Site Number 392001, Shinjuku-ku, Tokyo, Japan
🇯🇵
Investigational Site Number 392004, Chuo-ku, Chiba, Japan

and more 5 locations

A Randomized, Multicenter Open Label Study Comparing Early Administration of Azathioprine Plus IFX to Steroids Plus Azathioprine for Acute Severe Colitis

Phase 4

Completed

Conditions: Ulcerative Colitis

Interventions: Drug: Azathioprine
Drug: Infliximab
Drug: Prednisolone
Drug: Hydrocortisone

First Posted Date: 2015-04-24

Last Posted Date: 2023-05-31

Lead Sponsor: Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives

Target Recruit Count: 65

Registration Number: NCT02425852

Locations: 🇫🇷
APHP- Hopital BEAUJON, Clichy, France
🇫🇷
Hopital St Antoine, Paris, France
🇫🇷
Chu Besancon, Besancon, France

and more 13 locations

A Study of Abiraterone Acetate in Metastatic Castration-Resistant Prostate Cancer Participants Who Responded Poorly to the First-line Combined Androgen Blockade Therapy

Phase 4

Completed

Conditions: Metastatic Castration-Resistant Prostate Cancer

Interventions: Drug: Abiraterone Acetate
Drug: Prednisolone

First Posted Date: 2015-04-01

Last Posted Date: 2018-12-21

Lead Sponsor: Janssen Pharmaceutical K.K.

Target Recruit Count: 51

Registration Number: NCT02405858

Steroids in Fulminant Hepatitis A in the Pediatric Age Group

Phase 4

Completed

Conditions: Fulminant Hepatic Failure

Interventions: Drug: prednisolone
Drug: methylprednisolone

First Posted Date: 2015-03-03

Last Posted Date: 2018-12-17

Lead Sponsor: National Liver Institute, Egypt

Target Recruit Count: 33

Registration Number: NCT02375867

Locations: 🇪🇬
National Liver Institute, Menoufia, Egypt

Descemet Endothelial Thickness Comparison Trial

Phase 4

Conditions: Keratoplasty
Grafting, Corneal
Transplantation, Cornea
Keratoplasty, Lamellar
Transplantation, Corneal

Interventions: Procedure: DSAEK
Procedure: DMEK
Device: Endoserter
Drug: Prednisolone
Drug: Ofloxacin
Drug: Tropicamide
Device: Jones Tube
Drug: Phenylephrine

First Posted Date: 2015-02-26

Last Posted Date: 2020-11-25

Lead Sponsor: Oregon Health and Science University

Target Recruit Count: 38

Registration Number: NCT02373137

Locations: 🇺🇸
Byers Eye Institute, Stanford University, Palo Alto, California, United States
🇺🇸
F. I. Proctor Foundation, University of California, San Francisco, San Francisco, California, United States
🇺🇸
Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, United States