Prednisolone

Generic Name: Prednisolone

Brand Names: Millipred Dp 6 Day

Drug Type: Small Molecule

Chemical Formula: C_₂₁H_₂₈O_₅

CAS Number: 50-24-8

Unique Ingredient Identifier: 9PHQ9Y1OLM

Background: Prednisolone is a glucocorticoid similar to cortisol used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects.

Prednisolone was granted FDA approval on 21 June 1955.

Indication: Prednisolone is indicated to treat endocrine, rheumatic, and hematologic disorders; collagen, dermatologic, ophthalmic, respiratory, and gastrointestinal diseases; allergic and edematous states; and other conditions like tuberculous meningitis.

Associated Conditions: Acute Gouty Arthritis, Acute Leukemia, Allergic Bronchopulmonary Aspergillosis, Allergic Conjunctivitis (AC), Allergic Contact Dermatitis, Allergic Skin Reaction, Allergic corneal marginal ulcers, Alveolitis, Extrinsic Allergic, Ankylosing Spondylitis (AS), Aspiration Pneumonia, Aspiration Pneumonitis, Atopic Dermatitis, Bell's Palsy, Berylliosis, Bullous dermatitis herpetiformis, Burns, Chorioretinitis, Choroiditis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Conjunctivitis, Contact Dermatitis, Corneal injuries, Corneal ulceration, Crohn's Disease (CD), Cyclitis, Dermatomyositis (DM), Dermatosis of the Ear Canal, Drug hypersensitivity reaction, Edema of the cerebrum, Epicondylitis, Erythroblastopenia, Exacerbation of COPD, Exacerbation of asthma, Eye inflammation caused by Cataract Surgery, Eye inflammation caused by Infection, Fissure;Anal, Herpes Zoster Keratitis, Hot Water Burns (Scalds), Hypercalcemia of Malignancy, Idiopathic Pulmonary Fibrosis (IPF), Immune Thrombocytopenia (ITP), Inflamed External Hemorrhoid, Inflamed Hemorrhoids, Internal, Inflammatory Reaction caused by susceptible Bacterial Infections, Iridocyclitis, Iritis, Itching caused by susceptible Bacterial Infections, Keratitis, Loeffler's syndrome, Lymphoma, Metastatic Castration-Resistant Prostate Cancer (mCRPC), Multiple sclerosis exacerbation, Mycosis Fungoides (MF), Ocular Inflammation, Ophthalmia, Sympathetic, Optic Neuritis, Otic Eczema, Pemphigus, Perennial Allergic Rhinitis (PAR), Pericarditis, Pneumocystis Jirovecii Pneumonia, Polymyalgia Rheumatica (PMR), Posterior Uveitis, Posttraumatic Osteoarthritis, Proctitis, Proteinuria, Pruritus, Pruritus Ani, Psoriatic Arthritis, Pulmonary Tuberculosis (TB), Pure Red Cell Aplasia, Rash, Relapsing Polychondritis, Rheumatoid Arthritis, Rheumatoid Arthritis, Juvenile, Rosacea, Seasonal Allergic Rhinitis, Secondary Adrenal Insufficiency, Secondary thrombocytopenia, Serum Sickness, Severe Asthma, Sjogren's Syndrome (SS), Stevens-Johnson Syndrome, Superficial punctate keratitis, Synovitis, Systemic Lupus Erythematosus, Transplanted Organ Rejection, Trichinosis, Tuberculosis (TB), Tuberculous Meningitis, Ulcerative Colitis, Uveitis, Vasculitis, Acquired immune hemolytic anemia, Acute Bursitis, Acute Rheumatic heart disease, unspecified, Acute Tenosynovitis, Anal eczema, Bacterial skin infections, Exfoliative erythroderma, Idiopathic Bronchiolitis obliterans with organizing pneumonia, Idiopathic eosinophilic pneumonias, Non-suppurative Thyroiditis, Primary adrenocoritical insufficiency, Severe Psoriasis, Severe Seborrhoeic dermatitis, Severe alcoholic liver disease, Steroid-responsive inflammation of the eye, Subacute Bursitis, Susceptible Bacterial Infections, Symptomatic Sarcoidosis, Varicella-zoster virus acute retinal necrosis

Associated Therapies: -

Clinical Trials

Prednisone and Acupuncture for the Treatment of Facial Neuritis: a Multiple Center, CER in China

Not Applicable

Conditions: Bell's Palsy

Interventions: Device: acupuncture
Other: other treatment
Drug: Prednisolone

First Posted Date: 2010-09-14

Last Posted Date: 2014-08-20

Lead Sponsor: Xijing Hospital

Target Recruit Count: 1800

Registration Number: NCT01201642

Locations: 🇨🇳
the Department of Neurology , Xijing Hospital, Xi'an, Shaanxi, China

Myfortic® for Minimal Change Nephrotic Syndrome (MCNS): a Randomized Study

Phase 4

Completed

Conditions: Nephrosis, Lipoid

Interventions: Drug: Myfortic plus low-dose steroid
Drug: Prednisolone

First Posted Date: 2010-08-19

Last Posted Date: 2018-06-01

Lead Sponsor: The University of Hong Kong

Target Recruit Count: 20

Registration Number: NCT01185197

Locations: 🇨🇳
Queen Mary Hospital, Hong Kong, China

Efficacy and Safety Study of SyB L-0501 for Patients With Multiple Myeloma

Phase 2

Terminated

Conditions: Multiple Myeloma

Interventions: Drug: SyB L-0501
Drug: prednisolone

First Posted Date: 2010-08-11

Last Posted Date: 2013-03-18

Lead Sponsor: SymBio Pharmaceuticals

Target Recruit Count: 5

Registration Number: NCT01179490

Locations: 🇯🇵
Research site, Fukuoka, Japan

The Electroretinogram in Healthy and Glucose Intolerant Young Men

Not Applicable

Completed

Conditions: Electroretinography

Interventions: Drug: Prednisolone
Behavioral: Lifestyle change

First Posted Date: 2010-06-10

Last Posted Date: 2010-12-08

Lead Sponsor: Glostrup University Hospital, Copenhagen

Target Recruit Count: 10

Registration Number: NCT01140932

Locations: 🇩🇰
Copenhagen University Hospital at Glostrup, Copenhagen, Denmark

Prednisolone +/- Addition of Anti-CD20 Antibody, Rituximab, in Patients With Immune Hemolytic Anemia

Phase 3

Completed

Conditions: Anemia, Hemolytic, Autoimmune

Interventions: Drug: prednisolone + mabthera
Drug: Prednisolone

First Posted Date: 2010-06-02

Last Posted Date: 2013-09-10

Lead Sponsor: Copenhagen University Hospital at Herlev

Target Recruit Count: 65

Registration Number: NCT01134432

Locations: 🇩🇰
Aalborg Hospital, Aalborg, Denmark
🇩🇰
Haderslev Sygehus, Haderslev, Denmark
🇩🇰
Naestved Sygehus, Naestved, Denmark

and more 8 locations

RituxiMab INDuction in Renal Transplantation

Phase 4

Conditions: Function of Renal Transplant

Interventions: Drug: Tacrolimus
Drug: Rituximab
Drug: Mycophenylate mofetil
Drug: Hydrocortisone
Drug: Prednisolone

First Posted Date: 2010-03-30

Last Posted Date: 2020-07-22

Lead Sponsor: Guy's and St Thomas' NHS Foundation Trust

Target Recruit Count: 100

Registration Number: NCT01095172

Locations: 🇬🇧
Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom
🇬🇧
East Kent Hospitals NHS Foundation Trust, Canterbury, Kent, United Kingdom
🇬🇧
Glasgow Renal and Transplant Unit, Glasgow, United Kingdom

and more 3 locations