Prednisolone

Generic Name: Prednisolone

Brand Names: Millipred Dp 6 Day

Drug Type: Small Molecule

Chemical Formula: C_₂₁H_₂₈O_₅

CAS Number: 50-24-8

Unique Ingredient Identifier: 9PHQ9Y1OLM

Background: Prednisolone is a glucocorticoid similar to cortisol used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects.

Prednisolone was granted FDA approval on 21 June 1955.

Indication: Prednisolone is indicated to treat endocrine, rheumatic, and hematologic disorders; collagen, dermatologic, ophthalmic, respiratory, and gastrointestinal diseases; allergic and edematous states; and other conditions like tuberculous meningitis.

Associated Conditions: Acute Gouty Arthritis, Acute Leukemia, Allergic Bronchopulmonary Aspergillosis, Allergic Conjunctivitis (AC), Allergic Contact Dermatitis, Allergic Skin Reaction, Allergic corneal marginal ulcers, Alveolitis, Extrinsic Allergic, Ankylosing Spondylitis (AS), Aspiration Pneumonia, Aspiration Pneumonitis, Atopic Dermatitis, Bell's Palsy, Berylliosis, Bullous dermatitis herpetiformis, Burns, Chorioretinitis, Choroiditis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Conjunctivitis, Contact Dermatitis, Corneal injuries, Corneal ulceration, Crohn's Disease (CD), Cyclitis, Dermatomyositis (DM), Dermatosis of the Ear Canal, Drug hypersensitivity reaction, Edema of the cerebrum, Epicondylitis, Erythroblastopenia, Exacerbation of COPD, Exacerbation of asthma, Eye inflammation caused by Cataract Surgery, Eye inflammation caused by Infection, Fissure;Anal, Herpes Zoster Keratitis, Hot Water Burns (Scalds), Hypercalcemia of Malignancy, Idiopathic Pulmonary Fibrosis (IPF), Immune Thrombocytopenia (ITP), Inflamed External Hemorrhoid, Inflamed Hemorrhoids, Internal, Inflammatory Reaction caused by susceptible Bacterial Infections, Iridocyclitis, Iritis, Itching caused by susceptible Bacterial Infections, Keratitis, Loeffler's syndrome, Lymphoma, Metastatic Castration-Resistant Prostate Cancer (mCRPC), Multiple sclerosis exacerbation, Mycosis Fungoides (MF), Ocular Inflammation, Ophthalmia, Sympathetic, Optic Neuritis, Otic Eczema, Pemphigus, Perennial Allergic Rhinitis (PAR), Pericarditis, Pneumocystis Jirovecii Pneumonia, Polymyalgia Rheumatica (PMR), Posterior Uveitis, Posttraumatic Osteoarthritis, Proctitis, Proteinuria, Pruritus, Pruritus Ani, Psoriatic Arthritis, Pulmonary Tuberculosis (TB), Pure Red Cell Aplasia, Rash, Relapsing Polychondritis, Rheumatoid Arthritis, Rheumatoid Arthritis, Juvenile, Rosacea, Seasonal Allergic Rhinitis, Secondary Adrenal Insufficiency, Secondary thrombocytopenia, Serum Sickness, Severe Asthma, Sjogren's Syndrome (SS), Stevens-Johnson Syndrome, Superficial punctate keratitis, Synovitis, Systemic Lupus Erythematosus, Transplanted Organ Rejection, Trichinosis, Tuberculosis (TB), Tuberculous Meningitis, Ulcerative Colitis, Uveitis, Vasculitis, Acquired immune hemolytic anemia, Acute Bursitis, Acute Rheumatic heart disease, unspecified, Acute Tenosynovitis, Anal eczema, Bacterial skin infections, Exfoliative erythroderma, Idiopathic Bronchiolitis obliterans with organizing pneumonia, Idiopathic eosinophilic pneumonias, Non-suppurative Thyroiditis, Primary adrenocoritical insufficiency, Severe Psoriasis, Severe Seborrhoeic dermatitis, Severe alcoholic liver disease, Steroid-responsive inflammation of the eye, Subacute Bursitis, Susceptible Bacterial Infections, Symptomatic Sarcoidosis, Varicella-zoster virus acute retinal necrosis

Associated Therapies: -

Clinical Trials

Effectiveness of Methotrexate Versus Prednisolone as First-line Therapy for Pulmonary Sarcoidosis

Phase 4

Active, not recruiting

Conditions: Sarcoidosis, Pulmonary

Interventions: Drug: Methotrexate
Drug: Prednisolone

First Posted Date: 2020-03-19

Last Posted Date: 2024-03-12

Lead Sponsor: Erasmus Medical Center

Target Recruit Count: 138

Registration Number: NCT04314193

Locations: 🇳🇱
Jeroen Bosch Ziekenhuis, 's-Hertogenbosch, Netherlands
🇳🇱
Onze Lieve Vrouwe Gasthuis, Amsterdam, Netherlands
🇳🇱
Isala Klinieken, Zwolle, Netherlands

and more 15 locations

A Study to Evaluate the Safety, Tolerability, and Efficacy of MORAb-202 (Herein Referred to as Farletuzumab Ecteribulin), a Folate Receptor Alpha (FRα)-Targeting Antibody-drug Conjugate (ADC) in Participants With Selected Tumor Types

Phase 1

Recruiting

Conditions: Solid Tumor

Interventions: Drug: Farletuzumab ecteribulin
Drug: Prednisone
Drug: Prednisolone
Drug: Dexamethasone

First Posted Date: 2020-03-09

Last Posted Date: 2024-12-09

Lead Sponsor: Eisai Inc.

Target Recruit Count: 142

Registration Number: NCT04300556

Locations: 🇺🇸
Chattanooga's Program In Women's Oncology, Chattanooga, Tennessee, United States
🇺🇸
Arizona Clinical Research Center - Hunt - PPDS, Tucson, Arizona, United States
🇺🇸
University of Arkansas For Medical Sciences, Little Rock, Arkansas, United States

and more 50 locations

Deflazacort vs. Prednisolone in Acute-stage ABPA

Phase 2

Active, not recruiting

Conditions: Allergic Bronchopulmonary Aspergillosis

Interventions: Drug: Deflazacort
Drug: Prednisolone

First Posted Date: 2020-01-13

Last Posted Date: 2023-11-27

Lead Sponsor: Post Graduate Institute of Medical Education and Research, Chandigarh

Target Recruit Count: 150

Registration Number: NCT04227483

Locations: 🇮🇳
Chest Clinic, Dept. of Pulmonary Medicine, Chandigarh, India

Sintilimab in Combination With R-CHOP in Patients With Treatment-naive EBV-positive DLBCL, NOS

Phase 2

Conditions: EBV-Positive DLBCL, Nos

Interventions: Drug: Sintilimab
Drug: Rituximab
Drug: Cyclophosphamide
Drug: Doxorubicin
Drug: Vincristine
Drug: Prednisolone

First Posted Date: 2019-11-29

Last Posted Date: 2019-11-29

Lead Sponsor: The First Affiliated Hospital with Nanjing Medical University

Target Recruit Count: 55

Registration Number: NCT04181489

Locations: 🇨🇳
The first Affiliated Hospital Of Nanjing Medical University(JiangSu Province Hospital), NanJing, Jiangsu, China
🇨🇳
Drum tower hospital, Nanjing, Jiangsu, China
🇨🇳
Xuzhou Central Hospital, Xuzhou, Jiangsu, China

and more 8 locations

A Study to Evaluate the Efficacy and Safety of Upadacitinib in Participants With Takayasu Arteritis (TAK)

Phase 3

Active, not recruiting

Conditions: Takayasu Arteritis (TAK)

Interventions: Drug: Upadacitinib
Drug: Placebo for Upadacitinib
Drug: Prednisolone

First Posted Date: 2019-11-13

Last Posted Date: 2024-10-04

Lead Sponsor: AbbVie

Target Recruit Count: 56

Registration Number: NCT04161898

Locations: 🇧🇷
Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao /ID# 241175, Sao Paulo, Brazil
🇯🇵
Institute of Science Tokyo Hospital /ID# 214138, Bunkyo-ku, Tokyo, Japan
🇰🇷
The Catholic University of Korea, Seoul St. Marys Hospital /ID# 214566, Seoul, Seoul Teugbyeolsi, Korea, Republic of

and more 45 locations

Efficacy of Lower Dose Prednisolone in the Induction of Remission of Lupus Nephritis

Phase 4

Completed

Conditions: Lupus Nephritis

Interventions: Drug: Prednisolone

First Posted Date: 2019-10-31

Last Posted Date: 2019-10-31

Lead Sponsor: Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh

Target Recruit Count: 32

Registration Number: NCT04146220

Locations: 🇧🇩
Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh

Acute Exacerbations Treated With BenRAlizumab (The ABRA Study)

Phase 2

Active, not recruiting

Conditions: Asthma
COPD

Interventions: Drug: Prednisolone
Drug: Benralizumab

First Posted Date: 2019-09-23

Last Posted Date: 2024-01-23

Lead Sponsor: University of Oxford

Target Recruit Count: 158

Registration Number: NCT04098718

Locations: 🇬🇧
Oxford University Hospitals NHS Foundation Trust, Oxford, Oxfordshire, United Kingdom

Efficacy of Immunoglobulin Plus Prednisolone in Reducing Coronary Artery Lesion in Patients With Kawasaki Disease

Phase 3

Recruiting

Conditions: Kawasaki Disease

Interventions: Drug: IVIG
Drug: Aspirin
Drug: Prednisolone

First Posted Date: 2019-09-06

Last Posted Date: 2024-11-05

Lead Sponsor: Children's Hospital of Fudan University

Target Recruit Count: 3200

Registration Number: NCT04078568

Locations: 🇨🇳
Bengbu First People's Hopital, Bengbu, Anhui, China
🇨🇳
Anhui Children's Hospital, Hefei, Anhui, China
🇨🇳
Children's Hospital, Capital Institute of Pediatrics, Beijing, Beijing, China

and more 33 locations