Prednisolone

Generic Name: Prednisolone

Brand Names: Millipred Dp 6 Day

Drug Type: Small Molecule

Chemical Formula: C_₂₁H_₂₈O_₅

CAS Number: 50-24-8

Unique Ingredient Identifier: 9PHQ9Y1OLM

Background: Prednisolone is a glucocorticoid similar to cortisol used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects.

Prednisolone was granted FDA approval on 21 June 1955.

Indication: Prednisolone is indicated to treat endocrine, rheumatic, and hematologic disorders; collagen, dermatologic, ophthalmic, respiratory, and gastrointestinal diseases; allergic and edematous states; and other conditions like tuberculous meningitis.

Associated Conditions: Acute Gouty Arthritis, Acute Leukemia, Allergic Bronchopulmonary Aspergillosis, Allergic Conjunctivitis (AC), Allergic Contact Dermatitis, Allergic Skin Reaction, Allergic corneal marginal ulcers, Alveolitis, Extrinsic Allergic, Ankylosing Spondylitis (AS), Aspiration Pneumonia, Aspiration Pneumonitis, Atopic Dermatitis, Bell's Palsy, Berylliosis, Bullous dermatitis herpetiformis, Burns, Chorioretinitis, Choroiditis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Conjunctivitis, Contact Dermatitis, Corneal injuries, Corneal ulceration, Crohn's Disease (CD), Cyclitis, Dermatomyositis (DM), Dermatosis of the Ear Canal, Drug hypersensitivity reaction, Edema of the cerebrum, Epicondylitis, Erythroblastopenia, Exacerbation of COPD, Exacerbation of asthma, Eye inflammation caused by Cataract Surgery, Eye inflammation caused by Infection, Fissure;Anal, Herpes Zoster Keratitis, Hot Water Burns (Scalds), Hypercalcemia of Malignancy, Idiopathic Pulmonary Fibrosis (IPF), Immune Thrombocytopenia (ITP), Inflamed External Hemorrhoid, Inflamed Hemorrhoids, Internal, Inflammatory Reaction caused by susceptible Bacterial Infections, Iridocyclitis, Iritis, Itching caused by susceptible Bacterial Infections, Keratitis, Loeffler's syndrome, Lymphoma, Metastatic Castration-Resistant Prostate Cancer (mCRPC), Multiple sclerosis exacerbation, Mycosis Fungoides (MF), Ocular Inflammation, Ophthalmia, Sympathetic, Optic Neuritis, Otic Eczema, Pemphigus, Perennial Allergic Rhinitis (PAR), Pericarditis, Pneumocystis Jirovecii Pneumonia, Polymyalgia Rheumatica (PMR), Posterior Uveitis, Posttraumatic Osteoarthritis, Proctitis, Proteinuria, Pruritus, Pruritus Ani, Psoriatic Arthritis, Pulmonary Tuberculosis (TB), Pure Red Cell Aplasia, Rash, Relapsing Polychondritis, Rheumatoid Arthritis, Rheumatoid Arthritis, Juvenile, Rosacea, Seasonal Allergic Rhinitis, Secondary Adrenal Insufficiency, Secondary thrombocytopenia, Serum Sickness, Severe Asthma, Sjogren's Syndrome (SS), Stevens-Johnson Syndrome, Superficial punctate keratitis, Synovitis, Systemic Lupus Erythematosus, Transplanted Organ Rejection, Trichinosis, Tuberculosis (TB), Tuberculous Meningitis, Ulcerative Colitis, Uveitis, Vasculitis, Acquired immune hemolytic anemia, Acute Bursitis, Acute Rheumatic heart disease, unspecified, Acute Tenosynovitis, Anal eczema, Bacterial skin infections, Exfoliative erythroderma, Idiopathic Bronchiolitis obliterans with organizing pneumonia, Idiopathic eosinophilic pneumonias, Non-suppurative Thyroiditis, Primary adrenocoritical insufficiency, Severe Psoriasis, Severe Seborrhoeic dermatitis, Severe alcoholic liver disease, Steroid-responsive inflammation of the eye, Subacute Bursitis, Susceptible Bacterial Infections, Symptomatic Sarcoidosis, Varicella-zoster virus acute retinal necrosis

Associated Therapies: -

Clinical Trials

International Cooperative Treatment Protocol for Children and Adolescents With Lymphoblastic Lymphoma

Phase 3

Recruiting

Conditions: Lymphoblastic Lymphoma, Childhood

Interventions: Drug: Cyclophosphamide
Drug: Cytarabine
Drug: Daunorubicin
Drug: Dexamethasone
Drug: 6-Mercaptopurine
Drug: Methotrexate
Drug: Doxorubicin
Drug: PEG asparaginase
Drug: Ifosfamide
Drug: Vincristine
Drug: Prednisone
Drug: Prednisolone
Drug: Thioguanine
Drug: Vindesine

First Posted Date: 2019-08-02

Last Posted Date: 2024-07-10

Lead Sponsor: University Hospital Muenster

Target Recruit Count: 683

Registration Number: NCT04043494

Locations: 🇳🇱
Princess Maxima Centre for Pediatric Oncology, Utrecht, Netherlands
🇫🇷
Unité d'hématologie pédiatrique CHRU de Lille - Hôpital Jeanne de Flandre, Lille, France
🇧🇪
UZ Antwerpen Kinderhemato-oncologie, Edegem, Belgium

and more 219 locations

A Registry Study to Observe Clinical Outcomes of Participants With High-risk Metastatic Hormone-naïve Prostate Cancer in Japan

Completed

Conditions: Prostatic Neoplasms

Interventions: Drug: Androgen-deprivation Therapy (ADT)
Drug: Bicalutamide
Drug: Abiraterone
Drug: Prednisolone
Drug: Docetaxel
Drug: Enzalutamide
Drug: Apalutamide

First Posted Date: 2019-07-26

Last Posted Date: 2024-12-06

Lead Sponsor: Janssen Pharmaceutical K.K.

Target Recruit Count: 979

Registration Number: NCT04034095

Locations: 🇯🇵
Akita University Hospital, Akita, Japan
🇯🇵
Juntendo University Hospital, Bunkyo Ku, Japan
🇯🇵
Tokyo Medical and Dental University Hospital, Bunkyo Ku, Japan

and more 74 locations

Pilocarpine After Combined Cataract/Trabectome Surgery

Phase 3

Withdrawn

Conditions: Open Angle Glaucoma
Ocular Hypertension

Interventions: Drug: Pilocarpine
Drug: Ofloxacin
Drug: Prednisolone

First Posted Date: 2019-07-02

Last Posted Date: 2022-04-07

Lead Sponsor: Montefiore Medical Center

Registration Number: NCT04005079

Locations: 🇺🇸
Montefiore Medical Center, Bronx, New York, United States

Rituximab and Belimumab Combination Therapy in PR3 Vasculitis

Phase 2

Conditions: ANCA Associated Vasculitis
Granulomatosis With Polyangiitis

Interventions: Drug: Rituximab
Drug: Belimumab
Drug: Prednisolone

First Posted Date: 2019-05-30

Last Posted Date: 2022-03-08

Lead Sponsor: Rachel Jones

Target Recruit Count: 31

Registration Number: NCT03967925

Locations: 🇬🇧
Addenbrooke's Hospital, Cambridge, United Kingdom
🇬🇧
Glasgow Royal Infirmary, Glasgow, United Kingdom
🇬🇧
Imperial College London, London, United Kingdom

and more 3 locations

Early Administration of Steroids in the Ambulance Setting

Phase 4

Active, not recruiting

Conditions: Asthma in Children

Interventions: Drug: Prednisolone

First Posted Date: 2019-05-24

Last Posted Date: 2024-10-24

Lead Sponsor: University of Florida

Target Recruit Count: 834

Registration Number: NCT03962894

Locations: 🇺🇸
Walton County EMS, DeFuniak Springs, Florida, United States
🇺🇸
Nassau County Fire Rescue Department, Yulee, Florida, United States
🇺🇸
Lee County Public Safety & Emergency Services, Fort Myers, Florida, United States

and more 4 locations

Intraorbital Injection Versus Oral Steroid in Anterior Idiopathic Orbital Inflammation

Phase 3

Recruiting

Conditions: Orbital Pseudotumor

Interventions: Drug: Triamcinolone + Betamethason
Drug: Prednisolone

First Posted Date: 2019-05-22

Last Posted Date: 2023-02-16

Lead Sponsor: Iran University of Medical Sciences

Target Recruit Count: 120

Registration Number: NCT03958344

Locations: 🇮🇷
Iran University of Medical Sciences, Tehrān, Tehran, Iran, Islamic Republic of

Inotuzumab Ozogamicin and Post-Induction Chemotherapy in Treating Patients With High-Risk B-ALL, Mixed Phenotype Acute Leukemia, and B-LLy

First Posted Date: 2019-05-22

Last Posted Date: 2024-12-04

Lead Sponsor: Children's Oncology Group

Target Recruit Count: 4997

Registration Number: NCT03959085

Locations: 🇺🇸
Henry Ford Health Saint John Hospital, Detroit, Michigan, United States
🇺🇸
Michigan State University Clinical Center, East Lansing, Michigan, United States
🇺🇸
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital, Grand Rapids, Michigan, United States

and more 225 locations

Exploring Durable Remission With Rituximab in Antineutrophil Cytoplasmic Antibody(ANCA)-Associated Vasculitis

Phase 3

Recruiting

Conditions: ANCA Associated Vasculitis

Interventions: Drug: Rituximab
Drug: endoxan
Drug: Methylprednisolone
Drug: Prednisolone

First Posted Date: 2019-05-08

Last Posted Date: 2023-12-14

Lead Sponsor: Leiden University Medical Center

Target Recruit Count: 100

Registration Number: NCT03942887

Locations: 🇳🇱
Noordwest Ziekenhuisgroep, Alkmaar, Netherlands
🇳🇱
HagaZiekenhuis, Den Haag, Netherlands
🇳🇱
Leiden University Medical Center, Leiden, Zuid-Holland, Netherlands

and more 1 locations