Aliskiren

Generic Name: Aliskiren

Brand Names: Rasilez, Tekturna, Tekturna Hct

Drug Type: Small Molecule

Chemical Formula: C_₃₀H_₅₃N_₃O_₆

CAS Number: 173334-57-1

Unique Ingredient Identifier: 502FWN4Q32

Background: Aliskiren is the first drug in the renin inhibitor drug class and is used for the treatment of hypertension. It was developed by Speedel and Novartis and initially approved by the FDA in early 2007. Aliskiren has been proven to efficacious in reducing blood pressure when used alone or in conjunction with other antihypertensive agents.

Indication: Aliskiren is used for the treatment of hypertension in children above 6 years and adults. This drug may also be used in conjunction with antihypertensives such as calcium channel blockers and thiazides in products form to provide additional blood pressure control.

Associated Conditions: Hypertension

Associated Therapies: -

Clinical Trials

The Effect of Aliskiren on Endothelial Function in Pre-Diabetes and Diabetes

Not Applicable

Completed

Conditions: Diabetes Type 2

Interventions: Drug: Placebo
Drug: Aliskiren

First Posted Date: 2010-07-20

Last Posted Date: 2017-03-28

Lead Sponsor: Beth Israel Deaconess Medical Center

Target Recruit Count: 124

Registration Number: NCT01165983

Locations: 🇺🇸
Beth Israel Deaconess Medical Center, Joslin Foot Center & Microcirculation Laboratory, Boston, Massachusetts, United States

Significance of Regional Ventriculo-arterial Coupling in Patients With Chronic Heart Failure

Phase 4

Conditions: Heart Failure

Interventions: Drug: Aliskiren

First Posted Date: 2010-07-02

Last Posted Date: 2010-07-02

Lead Sponsor: Taipei Veterans General Hospital, Taiwan

Target Recruit Count: 120

Registration Number: NCT01156207

Locations: 🇨🇳
Taipei Veterans General Hospital, Taipei, Taiwan
🇨🇳
National Taiwan University Hospital, Taipei, Taiwan

An Extension Study to Evaluate the Long Term Safety, Tolerability and Efficacy of Aliskiren Compared to Enalapril in Pediatric Hypertensive Patients 6-17 Years of Age

Phase 3

Completed

Conditions: Hypertension

Interventions: Drug: Aliskiren
Drug: Enalapril

First Posted Date: 2010-06-28

Last Posted Date: 2016-03-07

Lead Sponsor: Novartis Pharmaceuticals

Target Recruit Count: 208

Registration Number: NCT01151410

Locations: 🇹🇷
Novartis Investigative Site, Ankara, Turkey

Aliskiren Combined With Losartan in Proteinuric, Non-diabetic Chronic Kidney Disease

Phase 4

Completed

Conditions: Kidney Disease

Interventions: Drug: Aliskiren
Drug: Losartan

First Posted Date: 2010-06-24

Last Posted Date: 2015-07-03

Lead Sponsor: The University of Hong Kong

Target Recruit Count: 80

Registration Number: NCT01150201

Locations: 🇨🇳
Queen Mary Hospital, Hong Kong, China

Treatment of Adiposity Related hypErTension (TARGET)

Phase 4

Completed

Conditions: Hypertension
Abdominal Obesity
Metabolic Syndrome

Interventions: Drug: Hydrochlorothiazide
Drug: Aliskiren
Drug: Moxonidine
Drug: Placebo (for moxonidine and hydrochlorothiazide)
Drug: Placebo (for aliskiren)

First Posted Date: 2010-06-07

Last Posted Date: 2012-02-24

Lead Sponsor: UMC Utrecht

Target Recruit Count: 32

Registration Number: NCT01138423

Locations: 🇳🇱
UMC Utrecht, Utrecht, Netherlands

Aldosterone Breakthrough During Diovan, Tekturna, and Combination Therapy in Patients With Proteinuric Kidney Disease

Phase 4

Terminated

Conditions: Proteinuric Kidney Disease
Diabetic Nephropathy
Hypertensive Nephrosclerosis
IgA Nephropathy
Focal Segmental Glomerulosclerosis
Glomerulopathy (Obesity-associated)
Glomerulonephritis, Membranous

Interventions: Drug: Aliskiren
Drug: Valsartan

First Posted Date: 2010-05-24

Last Posted Date: 2014-05-15

Lead Sponsor: Columbia University

Target Recruit Count: 46

Registration Number: NCT01129557

Locations: 🇺🇸
Columbia University Medical Center, New York, New York, United States

Aliskiren in Patients With Idiopathic Membranous Nephropathy

Not Applicable

Withdrawn

Conditions: Idiopathic Membranous Nephropathy

Interventions: Drug: Aliskiren

First Posted Date: 2010-03-26

Last Posted Date: 2013-03-13

Lead Sponsor: Mayo Clinic

Registration Number: NCT01093781

Locations: 🇺🇸
Mayo Clinic in Rochester, Rochester, Minnesota, United States

The Effect of Tekturna on Endothelial Function and Endothelial Progenitor Cells in Patients With Early Atherosclerosis

Phase 3

Terminated

Conditions: Endothelial Dysfunction

Interventions: Drug: Placebo
Drug: Aliskiren

First Posted Date: 2010-02-11

Last Posted Date: 2013-02-13

Lead Sponsor: Mayo Clinic

Target Recruit Count: 22

Registration Number: NCT01067326

Locations: 🇺🇸
Mayo Clinic in Rochester, Rochester, Minnesota, United States

Evaluation of Aliskiren Efficacy by Different Methods of Blood Pressure Measurements

Phase 4

Terminated

Conditions: Blood Pressure, High

Interventions: Drug: Aliskiren

First Posted Date: 2010-02-02

Last Posted Date: 2017-01-11

Lead Sponsor: Meir Medical Center

Target Recruit Count: 50

Registration Number: NCT01060865

Locations: 🇮🇱
Clalit health services, Hertsliyah, Hasharon Area, Israel

Efficacy of Aliskiren Compared to Ramipril in the Treatment of Moderate Systolic Hypertensive Patients

Phase 4

Completed

Conditions: Essential Hypertension

Interventions: Drug: Ramipril
Drug: Aliskiren
Drug: Matching placebo to Aliskiren
Drug: Matching placebo to Ramipril

First Posted Date: 2010-01-05

Last Posted Date: 2012-04-03

Lead Sponsor: Novartis

Target Recruit Count: 506

Registration Number: NCT01042392

Locations: 🇫🇷
Novartis Investigative Site, Witry-Les-Reims, France
🇫🇷
Novartis Investigator Site, Marsilly, France
🇫🇷
Investigative Site, Toulon, France

Drug Development Updates

Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.

Home Terms & Conditions Privacy Policy