PHOXILIUM 1.2 MMOL/L PHOSPHATE SOLUTION FOR HAEMODIALYSIS/HAEMOFILTRATION

BAXTER HEALTHCARE (ASIA) PTE LTD

BAXTER HEALTHCARE (ASIA) PTE LTD

Therapeutic

Prescription Only

SOLUTION, STERILE

**4.2 Posology and method of administration** **Posology:** The volume and rate at which PHOXILIUM solution is administered depends on the blood concentration of phosphate and other electrolytes, acid–base balance, fluid balance and overall clinical condition of the patient. The volume of replacement solution and/or dialysate to be administered will also depend on the desired intensity (dose) of the treatment. Administration (dose, infusion rate and cumulative volume) of PHOXILIUM solution should only be established by a physician experienced in critical care medicine and CRRT (Continuous Renal Replacement Therapy). The dose volume is therefore at the discretion and prescription of the responsible physician. The range of flow rates for the replacement solution in haemofiltration and haemodiafiltration are: Adult: 500 – 3000 ml/hour The range of flow rates for the dialysate in continuous haemodialysis and continuous haemodiafiltration are: Adult: 500 – 2500 ml/hour Commonly used combined total flow rates for CRRT (dialysate and replacement solutions) in adults are approximately 2000 to 2500 ml/h which correspond to a daily fluid volume of approximately 48 to 60 l. **Paediatric population:** In children from neonates to adolescents to 18 years, the range of flow rates used as substitution solution in haemofiltration and haemodiafiltration and as dialysis solution (dialysate) in continuous haemodialysis and continuous haemodiafiltration are 1000 to 4000 ml/h/1.73 m2. For adolescents (12–18 years), the adult dose recommendation should be used when the paediatric dose is calculated to exceed the maximum adult dose. **Method of administration:** Intravenous use and for haemodialysis. PHOXILIUM solution, when used as a replacement solution is administered into the extracorporeal circuit before (pre-dilution) or after the haemofilter or haemodiafilter (post-dilution). PHOXILIUM solution, when used as a dialysate, it is administered in the dialysate compartment of the extracorporeal filter separated from the blood flow by a semipermeable membrane. For instructions on reconstitution of the medicinal product before administration, see section 6.6 – _please refer to the Product Insert/Patient Information Leaflet published on HSA for the full drug information_.