Calcium chloride

Overview

Calcium chloride is an ionic compound of calcium and chlorine. It is highly soluble in water and it is deliquescent. It is a salt that is solid at room temperature, and it behaves as a typical ionic halide. It has several common applications such as brine for refrigeration plants, ice and dust control on roads, and in cement. It can be produced directly from limestone, but large amounts are also produced as a by-product of the Solvay process. Because of its hygroscopic nature, it must be kept in tightly-sealed containers.

Indication

For the treatment of hypocalcemia in those conditions requiring a prompt increase in blood plasma calcium levels, for the treatment of magnesium intoxication due to overdosage of magnesium sulfate, and used to combat the deleterious effects of hyperkalemia as measured by electrocardiographic (ECG), pending correction of the increased potassium level in the extracellular fluid.

Associated Conditions

Acute Renal Failure (ARF)
Dehydration
Dehydration Hypertonic
Dry Mouth
Electrolyte depletion
End-stage Chronic Kidney Failure
Fluid Loss
Hyperkalemia
Hypocalcemia
Hypocalcemic tetany
Hypovolaemia
Isotonic Dehydration
Renal Failure, Chronic Renal Failure
Shock, Hypovolemic
Beta blocker overdose
Calcium channel blocker overdose

Clinical Trials

Title	Posted	Study ID	Phase	Status	Sponsor
Role of Calcium Chloride Injection in Alleviating Atrial Fibrillation Post CABG	2024/04/22	NCT06378021	Phase 3	Recruiting	Helwan University
Pharmacokinetic Equivalence of Calcium Gluconate and Calcium Chloride in Parturients	2023/08/03	NCT05973747	Early Phase 1	Completed	Stanford University
Does Topical Ophthalmic Proparacaine 0.5% Prior to Probing and Irrigation Decrease Pain?	2022/12/23	NCT05663684	Phase 4	Recruiting	Louisiana State University Health Sciences Center in New Orleans
20% Albumin vs. Balanced Salt Solution as Resuscitation Fluid in Cirrhosis With Sepsis Induced Hypotension	2022/07/01	NCT05441878	Phase 4	UNKNOWN	Post Graduate Institute of Medical Education and Research, Chandigarh
Calcium Electroporation for Basal Cell Carcinomas - Proof of Concept Study	2021/09/16	NCT05046262	Phase 3	UNKNOWN	Bispebjerg Hospital
Calcium Chloride for Prevention of Blood Loss During Intrapartum Cesarean Delivery	2021/08/30	NCT05027048	Phase 3	Completed	Stanford University
Does Topical Ophthalmic Anesthetic Prior to Probing and Irrigation Decrease Pain?	2020/01/18	NCT04229771	Phase 4	Terminated	William Beaumont Hospitals
Calcium for Out-of-Hospital Cardiac Arrest	2019/11/06	NCT04153435	Phase 2	Completed	Lars Wiuff Andersen
Calcium Chloride for Prevention of Uterine Atony During Cesarean	2019/03/08	NCT03867383	Phase 1	Completed	Stanford University
Calcium Administration in Cardiac Surgery	2018/12/12	NCT03772990	Phase 4	Completed	Meshalkin Research Institute of Pathology of Circulation

FDA Drug Approvals

Approved Product	Manufacturer	NDC Code	Route	Strength	Effective Date
CLINIMIX E	Baxter Healthcare Company	0338-0210	INTRAVENOUS	33 mg in 100 mL	9/21/2020
CLINIMIX E	Baxter Healthcare Corporation	0338-0210	INTRAVENOUS	33 mg in 100 mL	9/21/2020
Lactated Ringers	Baxter Healthcare Corporation	0338-0117	INTRAVENOUS	20 mg in 100 mL	10/9/2019
Calcium Chloride	Medical Purchasing Solutions, LLC	71872-7193	INTRAVENOUS	100 mg in 1 mL	5/10/2023
Potassium Chloride in Lactated Ringers and Dextrose	ICU Medical Inc.	0990-7111	INTRAVENOUS	0.2 g in 1000 mL	6/24/2021
DELFLEX	Fresenius Medical Care North America	49230-212	INTRAPERITONEAL	18.4 mg in 100 mL	10/19/2023
Lactated Ringers	Baxter Healthcare Corporation	0338-0137	IRRIGATION	200 mg in 1000 mL	9/29/2015
CLINIMIX E	Baxter Healthcare Company	0338-1147	INTRAVENOUS	33 mg in 100 mL	9/21/2020
CLINIMIX E	Baxter Healthcare Corporation	0338-1147	INTRAVENOUS	33 mg in 100 mL	9/21/2020
CLINIMIX E	Baxter Healthcare Company	0338-1142	INTRAVENOUS	33 mg in 100 mL	9/21/2020

EMA Drug Approvals

Approved Product	Authorization Holder	Status	Issued Date
No EMA approvals found for this drug.

HSA Drug Approvals

Approved Product	Manufacturer	Approval Number	Dosage Form	Strength	Approval Date
COMPOUND SODIUM LACTATE INTRAVENOUS INFUSION BP	B BRAUN MEDICAL INDUSTRIES SDN BHD, B. Braun Melsungen AG, B. Braun Medical SA	SIN06429P	INJECTION	0.027 g/100 ml	7/8/1991
LACTATED RINGER'S INJECTION USP	Baxter Healthcare Corporation, North Cove Plant, BAXTER HEALTHCARE PHILIPPINES INC	SIN05592P	INJECTION	20 mg/100 ml	3/27/1991
BAXTER-LACTATED RINGER’S INJECTION USP	Baxter Healthcare Philippines, Inc	SIN16604P	INFUSION, SOLUTION	20mg per 100mL	9/14/2022
HAEMODIALYSIS CONCENTRATE NKFS-01 (ACID) FOR BICARBONATE DIALYSIS	B BRAUN MEDICAL INDUSTRIES SDN BHD	SIN09474P	SOLUTION	7.77 g/l	8/21/1997
TISSEEL FIBRIN SEALANT VH S/D (FROZEN)	Takeda Manufacturing Austria AG (Site: Industriestrasse 72), Takeda Manufacturing Austria AG (Site: Lange Allee 24F) (Primary Packager)	SIN14707P	SOLUTION	36-44 umol/ml	12/22/2014
BERIPLAST P COMBI-SET 3ML POWDERS AND SOLVENTS FOR SEALANT	CSL Behring GmbH	SIN16776P	OTHER	17.7mg	5/10/2023
LACTORIDE 500 INFUSION	BEXIMCO PHARMACEUTICALS LTD	SIN09647P	INJECTION	0.027% w/v	2/18/1998
ARTISS SOLUTIONS FOR SEALANT, DEEP FROZEN	Takeda Manufacturing Austria AG (Site: Industriestrasse 72), Takeda Manufacturing Austria AG (Site: Lange Allee 24B), Takeda Manufacturing Austria AG (Site: Lange Allee 24A) (Primary and Secondary Packager)	SIN14719P	SOLUTION	36 – 44 μmol/ml	1/6/2015
BERIPLAST P COMBI-SET 1ML POWDERS AND SOLVENTS FOR SEALANT	CSL Behring GmbH	SIN16775P	OTHER	5.9mg	5/10/2023
DIANEAL LOW CALCIUM (2.5 mEq/l) PERITONEAL DIALYSIS SOLUTION WITH 1.5% DEXTROSE	BAXTER HEALTHCARE SA, SINGAPORE BRANCH, BAXTER HEALTHCARE CORPORATION	SIN06627P	SOLUTION, STERILE	18.3 mg/100 ml	10/14/1991

NMPA Drug Approvals

Approved Product	Company	Approval Number	Drug Type	Dosage Form	Approval Date
No NMPA approvals found for this drug.

PPB Drug Approvals

Approved Product	Registration No.	Company	Licence No.	Strength	Registration Date
EXTRANEAL SOLN 7.5%	N/A	Vantive Healthcare Limited	N/A	N/A	8/18/2000
PRISMASOL B0 SOLUTION FOR HAEMOFILTRATION AND HAEMODIALYSIS	N/A	Vantive Healthcare Limited	N/A	N/A	10/15/2013
RINGER'S INJ	N/A	otsuka pharmaceutical (h.k.) limited	N/A	N/A	5/15/2008
LACTATED RINGER'S INJ	N/A	LUEN CHEONG HONG	N/A	N/A	5/17/1979
OLIMEL N9E EMULSION FOR INFUSION	N/A	Baxter Healthcare Ltd	N/A	N/A	10/24/2013
NUTRIFLEX OMEGA SPECIAL EMULSION FOR INFUSION	N/A	B BRAUN MEDICAL SA	N/A	N/A	1/11/2012
BALANCE 4.25% GLU. 1.25MMOL/L CAL. P.D. SOLUTION (JAPAN)	N/A	FRESENIUS MEDICAL CARE HONG KONG LIMITED	N/A	N/A	7/12/2005
WIDA RL RINGER LACTATE INTRAVENOUS INFUSION	N/A	otsuka pharmaceutical (h.k.) limited	N/A	N/A	10/30/2009
SMOFKABIVEN EMULSION FOR INFUSION	N/A	FRESENIUS KABI HONG KONG LIMITED	N/A	N/A	5/26/2011
NAMIDA EYE-RUBY EYE DROPS	N/A	eng an trading company limited	N/A	N/A	5/7/1996

TGA Drug Approvals

Approved Product	ARTG ID	Sponsor	Registration Type	Status	Registration Date
SLEEP SAFE BALANCE 1.5% glucose 1.75 mmol/L calcium peritoneal dialysis solution bag	92935	Fresenius Medical Care Australia Pty Ltd	Medicine	A	6/20/2003
DBL CALCIUM CHLORIDE 0.74g/5mL Injection	16361	Phebra Pty Ltd	Medicine	A	10/8/1991
SMOFKABIVEN amino acids 5.1% / lipids 3.8% / glucose 12.7% / electrolytes 0.7% emulsion for intravenous infusion bag 1970 mL	180546	Fresenius Kabi Australia Pty Ltd	Medicine	A	1/9/2012
ARTISS fibrin sealant VH S/D 4 IU (frozen) solution for sealant syringe	163515	Baxter Healthcare Pty Ltd	Medicine	A	8/19/2010
OLICLINOMEL N4-550 E 1000 mL IV emulsion for infusion with electrolytes bag	136599	Baxter Healthcare Pty Ltd	Medicine	A	9/4/2007
OLICLINOMEL N4-550 E 2500 mL IV emulsion for infusion with electrolytes bag	141396	Baxter Healthcare Pty Ltd	Medicine	A	9/4/2007
OLIMEL N5-860E Emulsion for intravenous infusion	197417	Baxter Healthcare Pty Ltd	Medicine	A	8/9/2013
HEMOSOL B0 haemofiltration / haemodiafiltration solution bag	260992	Vantive Pty Ltd	Medicine	A	12/14/2016
SMOFKABIVEN LOW OSMO amino acids 2.5%, electrolytes 0.4%, lipids 3.5% & glucose 6.8% emulsion for intravenous infusion 2500 mL biofine bag	329619	Fresenius Kabi Australia Pty Ltd	Medicine	A	8/27/2020
MULTIBIC potassium-free, Solution for Haemofiltration	357591	Fresenius Medical Care Australia Pty Ltd	Medicine	A	8/2/2021

Health Canada Drug Approvals

Approved Product	Company	DIN	Dosage Form	Strength	Market Date
ACID CONCENTRATE RZ119C	genpharm ulc	N/A	Liquid - Haemodialysis	9.924 G / L	12/31/1995
ACID CONCENTRATE RO4137	genpharm ulc	N/A	Liquid - Haemodialysis	6.769 G / L	12/31/1995
SB 1000	renal systems, division of minntech corp.	00678783	Liquid - Haemodialysis	9.5 G / L	12/31/1985
SELECTBAG ONE (AX 450 G)	Vantive ULC	02415488	Solution - Haemodialysis	44.1 G / L	4/21/2017
PRISMASOL 2	Vantive ULC	02277441	Solution - Intravenous , Haemodialysis	5.145 G / L	2/21/2006
ACID CONCENTRATE D-18003	baxter corporation	02158132	Liquid - Haemodialysis	4.85 G / L	12/31/1995
ACID CONCENTRATE RZ254C	genpharm ulc	02178389	Liquid - Haemodialysis	8.27 G / L	12/31/1995
ACID CONCENTRATE D12303	althin biopharm inc.	02217627	Liquid - Haemodialysis	8.78 G / L	12/31/1996
CALCIUM CHLORIDE BP - ADDITIVE FOR CONCENTRATED HAEMODIALYSIS SOLUTIONS	genpharm ulc	02230676	Powder - Haemodialysis	12.32 G / VIAL	6/18/1998
FORMULA 22158	therapeutic foods co.	00191531	Capsule - Oral	7 MG / CAP	5/18/1994

CIMA AEMPS Drug Approvals

Approved Product	Company	Registration Number	Pharmaceutical Form	Prescription Type	Status
CELSIOR SOLUCION PARA LA CONSERVACION DE ORGANOS	Institut Georges Lopez	73767	SOLUCIÓN PARA CONSERVACIÓN DE ÓRGANOS	Uso Hospitalario	Commercialized
BICAVERA GLUCOSA 1,5%, Calcio 1,75 mmol/l SOLUCION PARA DIALISIS PERITONEAL	Fresenius Medical Care Deutschland Gmbh	64755	SOLUCION PARA DIALISIS PERITONEAL	Uso Hospitalario	Commercialized
TISSEEL SOLUCIONES PARA ADHESIVO TISULAR	Baxter S.L.	78896	SOLUCIÓN PARA ADHESIVO TISULAR	Uso Hospitalario	Commercialized
KABIPAC SOLUCION RINGER SOLUCIÓN PARA PERFUSIÓN	Fresenius Kabi España, S.A.U.	60265	SOLUCIÓN PARA PERFUSIÓN	Medicamento Sujeto A Prescripción Médica	Commercialized
MULTIBIC 3 MMOL/L DE POTASIO SOLUCIÓN PARA HEMODIÁLISIS Y HEMOFILTRACIÓN	Fresenius Medical Care Deutschland Gmbh	65814	SOLUCIÓN PARA HEMOFILTRACIÓN	Medicamento Sujeto A Prescripción Médica	Commercialized
MULTIBIC 4 MMOL/L DE POTASIO SOLUCIÓN PARA HEMODIÁLISIS Y HEMOFILTRACIÓN	Fresenius Medical Care Deutschland Gmbh	65815	SOLUCIÓN PARA HEMOFILTRACIÓN	Medicamento Sujeto A Prescripción Médica	Commercialized
KABIVEN EMULSION PARA PERFUSION	Fresenius Kabi Ab	62985	EMULSIÓN PARA PERFUSIÓN	Uso Hospitalario	Commercialized
PRISMASOL 2 mmol/l POTASIO, SOLUCION PARA HEMODIALISIS Y HEMOFILTRACION	Vantive Belgium	65896	SOLUCIÓN PARA HEMOFILTRACIÓN	Uso Hospitalario	Commercialized
KABIVEN PERIFERICO EMULSION PARA PERFUSION	Fresenius Kabi Ab	63596	EMULSIÓN PARA PERFUSIÓN	Uso Hospitalario	Not Commercialized
CLORURO DE CALCIO BRAUN 100 mg/ml SOLUCION INYECTABLE	B Braun Medical S.A.	49072	SOLUCIÓN INYECTABLE	Medicamento Sujeto A Prescripción Médica	Commercialized

Philippines FDA Drug Approvals

Approved Product	Company	License Number	Dosage Form	Strength	Approval Date
No Philippines FDA approvals found for this drug.

Saudi SFDA Drug Approvals

Approved Product	Company	License Number	Dosage Form	Strength	Approval Date
No Saudi SFDA approvals found for this drug.

Malaysia NPRA Drug Approvals

Approved Product	Company	Registration Number	Dosage Form	Strength	Approval Date
No Malaysia NPRA approvals found for this drug.

UK EMC Drug Information

Medicine Name	MA Holder	MA Number	Pharmaceutical Form	Active Ingredient	Authorization Date
No UK EMC drug information found for this drug.

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