Regadenoson
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Regadenoson is a coronary vasodilator used in radionuclide myocardial perfusion imaging (MPI).
Regadenoson is a coronary vasodilator used in radionuclide myocardial perfusion imaging (MPI).
Regadenoson is an selective low-affinity (Ki= 1.3 µM) A2A receptor agonist that mimics the effects of adenosine in causing coronary vasodilatation and increasing myocardial blood flow. It is a very weak agonist of the A1 adenosine receptor (Ki > 16.5 µM). Furthermore, it has negligible affinity to A2B and A3 adenosine receptors. Regadenoson is undergoing trials for use in pharmacological stress tests. Adenosine slows conduction time through the A-V node, can interrupt the reentry pathways through the A-V node, and can restore normal sinus rhythm in patients with paroxysmal supraventricular tachycardia (PSVT), including PSVT associated with Wolff-Parkinson-White Syndrome.
Diagnostic agent for radionuclide myocardial perfusion imaging (MPI)
