Etanercept

Generic Name
Etanercept
Brand Names
Enbrel, Eticovo, Benepali, Erelzi, Nepexto
Drug Type
Biotech
Chemical Formula
-
CAS Number
185243-69-0
Unique Ingredient Identifier
OP401G7OJC
Background

Dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kilodalton (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1. The Fc component of etanercept contains the CH2 domain, the CH3 domain and hinge region, but not the CH1 domain of IgG1. Etanercept is produced by recombinant DNA technolo...

Indication

Etanercept is indicated for the treatment of moderately to severely active rheumatoid arthritis in adults and in chronic moderate to severe plaque psoriasis in patients 4 years of age and older. It is also used to manage signs and symptoms of polyarticular idiopathic arthritis and Juvenile Psoriatic Arthritis in those aged 2 years and older. Etanercept is al...

Associated Conditions
Active Juvenile Psoriatic Arthritis, Ankylosing Spondylitis (AS), Graft-versus-host Disease (GVHD), Polyarticular Juvenile Idiopathic Arthritis, Psoriasis Vulgaris (Plaque Psoriasis), Psoriatic Arthritis, Pyoderma Gangrenosum, Rheumatoid Arthritis, Severe Plaque psoriasis, Stevens-Johnson Syndrome, Chronic, severe Psoriatic Arthritis, Moderate Plaque psoriasis, Moderate, active Rheumatoid arthritis, Severe, active Rheumatoid arthritis
Associated Therapies
-

Double-blind, Randomized, Placebo-controlled Phase 3 Study of Etanercept in the Treatment of Psoriatic Arthritis and Psoriasis

Phase 3
Completed
Conditions
Interventions
First Posted Date
2006-04-25
Last Posted Date
2010-12-23
Lead Sponsor
Amgen
Target Recruit Count
205
Registration Number
NCT00317499

Safety and Tolerability of Rituxan With Methotrexate and Etanercept or Methotrexate and Adalimumab in Patients With Active Rheumatoid Arthritis

First Posted Date
2006-03-02
Last Posted Date
2015-09-28
Lead Sponsor
Biogen
Target Recruit Count
54
Registration Number
NCT00298272
Locations
🇺🇸

Research Site, Burlington, Vermont, United States

🇺🇸

Research site, Chardon, Ohio, United States

Study Evaluating the Safety and Efficacy of Etanercept in Patients With Psoriatic Arthritis Treated by Dermatologists

First Posted Date
2006-02-17
Last Posted Date
2014-02-26
Lead Sponsor
Pfizer
Target Recruit Count
129
Registration Number
NCT00293709
Locations
🇩🇪

Pfizer Investigational Site, Muenchen, Germany

Safety and Efficacy Study of the Effect of Etanercept in Hemodialysis Patients

Phase 2
Terminated
Conditions
Interventions
First Posted Date
2006-02-17
Last Posted Date
2021-07-13
Lead Sponsor
Kaysen, George A., M.D., Ph.D.
Target Recruit Count
10
Registration Number
NCT00293202
Locations
🇺🇸

University of California, Davis, Medical Center, Sacramento, California, United States

Study Evaluating the Safety and Efficacy of Etanercept in Patients With Psoriatic Arthritis Treated by Rheumatologists

First Posted Date
2006-02-17
Last Posted Date
2014-02-26
Lead Sponsor
Pfizer
Target Recruit Count
1308
Registration Number
NCT00293722
Locations
🇩🇪

Pfizer Investigational Site, Toerwang-Samerberg, Germany

Use of Etanercept in the Treatment of Moderate to Severe Lichen Planus

Phase 2
Terminated
Conditions
Interventions
First Posted Date
2006-02-02
Last Posted Date
2018-03-21
Lead Sponsor
Stanford University
Target Recruit Count
27
Registration Number
NCT00285779
Locations
🇺🇸

Cleveland Clinic Foundation, Cleveland, Ohio, United States

🇺🇸

Emory University, Atlanta, Georgia, United States

🇺🇸

Stanford University Medical Center, Stanford, California, United States

and more 9 locations

TNF Alpha in Refractory Asthma

Not Applicable
Completed
Conditions
First Posted Date
2006-01-12
Last Posted Date
2006-05-04
Lead Sponsor
University Hospitals, Leicester
Target Recruit Count
10
Registration Number
NCT00276029
Locations
🇬🇧

Institute for Lung Health, Leicester, Leicestershire, United Kingdom

Treatment of Early Aggressive Rheumatoid Arthritis (TEAR)

First Posted Date
2005-11-29
Last Posted Date
2014-07-17
Lead Sponsor
University of Alabama at Birmingham
Target Recruit Count
755
Registration Number
NCT00259610
Locations
🇺🇸

University of Alabama at Birmingham, Birmingham, Alabama, United States

Study Evaluating the Combination of Etanercept and Methotrexate in Rheumatoid Arthritis Subjects

Phase 4
Completed
Conditions
First Posted Date
2005-11-11
Last Posted Date
2011-05-18
Lead Sponsor
Wyeth is now a wholly owned subsidiary of Pfizer
Target Recruit Count
300
Registration Number
NCT00252668

Study Evaluating Etanercept and Sulphasalazine in Ankylosing Spondylitis

First Posted Date
2005-11-02
Last Posted Date
2012-11-08
Lead Sponsor
Wyeth is now a wholly owned subsidiary of Pfizer
Target Recruit Count
566
Registration Number
NCT00247962
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