Etanercept

Generic Name
Etanercept
Brand Names
Enbrel, Eticovo, Benepali, Erelzi, Nepexto
Drug Type
Biotech
Chemical Formula
-
CAS Number
185243-69-0
Unique Ingredient Identifier
OP401G7OJC
Background

Dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kilodalton (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1. The Fc component of etanercept contains the CH2 domain, the CH3 domain and hinge region, but not the CH1 domain of IgG1. Etanercept is produced by recombinant DNA technolo...

Indication

Etanercept is indicated for the treatment of moderately to severely active rheumatoid arthritis in adults and in chronic moderate to severe plaque psoriasis in patients 4 years of age and older. It is also used to manage signs and symptoms of polyarticular idiopathic arthritis and Juvenile Psoriatic Arthritis in those aged 2 years and older. Etanercept is al...

Associated Conditions
Active Juvenile Psoriatic Arthritis, Ankylosing Spondylitis (AS), Graft-versus-host Disease (GVHD), Polyarticular Juvenile Idiopathic Arthritis, Psoriasis Vulgaris (Plaque Psoriasis), Psoriatic Arthritis, Pyoderma Gangrenosum, Rheumatoid Arthritis, Severe Plaque psoriasis, Stevens-Johnson Syndrome, Chronic, severe Psoriatic Arthritis, Moderate Plaque psoriasis, Moderate, active Rheumatoid arthritis, Severe, active Rheumatoid arthritis
Associated Therapies
-

Study of TNF-Antagonism in the Metabolic Syndrome (II)

Not Applicable
Completed
Conditions
Interventions
First Posted Date
2006-12-19
Last Posted Date
2010-12-02
Lead Sponsor
Massachusetts General Hospital
Target Recruit Count
40
Registration Number
NCT00413400
Locations
🇺🇸

MGH, Boston, Massachusetts, United States

Study of TNF-Antagonism in Metabolic Syndrome

Not Applicable
Completed
Conditions
Interventions
First Posted Date
2006-12-08
Last Posted Date
2008-05-28
Lead Sponsor
Massachusetts General Hospital
Target Recruit Count
56
Registration Number
NCT00409318
Locations
🇺🇸

MGH, Boston, Massachusetts, United States

Rheumatoid Arthritis: Comparison of Active Therapies in Patients With Active Disease Despite Methotrexate Therapy

First Posted Date
2006-11-30
Last Posted Date
2013-12-03
Lead Sponsor
US Department of Veterans Affairs
Target Recruit Count
353
Registration Number
NCT00405275
Locations
🇺🇸

VA Medical Center, Loma Linda, Loma Linda, California, United States

🇺🇸

VA Pittsburgh Health Care System, Pittsburgh, Pennsylvania, United States

🇺🇸

Geisinger Medical Group - State College, State College, Pennsylvania, United States

and more 34 locations

Study Comparing Etanercept Plus Methotrexate to Either Etanercept or Methotrexate Alone in Rheumatoid Arthritis.

Phase 3
Completed
Conditions
First Posted Date
2006-10-27
Last Posted Date
2023-12-13
Lead Sponsor
Wyeth is now a wholly owned subsidiary of Pfizer
Target Recruit Count
615
Registration Number
NCT00393471

Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) to Measure Response to Etanercept in Rheumatoid Arthritis

Phase 1
Completed
Conditions
Interventions
First Posted Date
2006-08-08
Last Posted Date
2013-09-17
Lead Sponsor
Amgen
Target Recruit Count
14
Registration Number
NCT00361634
Locations
🇬🇧

Research Site, London, United Kingdom

16.0040 Ankylosing Spondylitis Study

Phase 3
Completed
Conditions
Interventions
First Posted Date
2006-07-26
Last Posted Date
2013-05-14
Lead Sponsor
Amgen
Target Recruit Count
257
Registration Number
NCT00356356

A Placebo-Controlled Double-Blind Study on the Safety and Efficacy of Etanercept in Palmoplantar Pustulosis

First Posted Date
2006-07-17
Last Posted Date
2011-09-09
Lead Sponsor
Innovaderm Research Inc.
Target Recruit Count
15
Registration Number
NCT00353119
Locations
🇨🇦

Innovaderm Research Incorporated, Montreal, Quebec, Canada

🇨🇦

Centre de Recherche Dermatologique du Québec métropolitain, Quebec, Canada

An Open-Label Study to Assess the Rate of Failure of an Enbrel® (Etanercept) SureClick™ Auto-injector in Subjects With Rheumatoid Arthritis

Phase 4
Completed
Conditions
Interventions
First Posted Date
2006-06-29
Last Posted Date
2020-01-22
Lead Sponsor
Amgen
Target Recruit Count
115
Registration Number
NCT00346294

Study Evaluating the Safety and Efficacy of Etanercept 50 mg Once Weekly in Subjects With Psoriasis

Phase 3
Completed
Conditions
First Posted Date
2006-06-02
Last Posted Date
2007-12-06
Lead Sponsor
Wyeth is now a wholly owned subsidiary of Pfizer
Target Recruit Count
120
Registration Number
NCT00333034

Observational Safety Study of Etanercept (Enbrel) for Treatment of Psoriasis

Completed
Conditions
Interventions
First Posted Date
2006-05-08
Last Posted Date
2018-06-28
Lead Sponsor
Amgen
Target Recruit Count
2511
Registration Number
NCT00322439
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