Dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kilodalton (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1. The Fc component of etanercept contains the CH2 domain, the CH3 domain and hinge region, but not the CH1 domain of IgG1. Etanercept is produced by recombinant DNA technology in a Chinese hamster ovary (CHO) mammalian cell expression system. It consists of 934 amino acids. It is used to treat or manage a variety of inflammatory conditions including rheumatoid arthritis (RA), ankylosing spondylitis (AS), and juvenile idiopathic poly-articular arthritis (JIA).
Etanercept is indicated for the treatment of moderately to severely active rheumatoid arthritis in adults and in chronic moderate to severe plaque psoriasis in patients 4 years of age and older. It is also used to manage signs and symptoms of polyarticular idiopathic arthritis and Juvenile Psoriatic Arthritis in those aged 2 years and older. Etanercept is also used to manage the symptoms of psoriatic arthritis and ankylosing spondylitis.
Investigational Site Number 840203, Washington, D.C., District of Columbia, United States
Investigational Site Number 032009, Zarate, Argentina
Investigational Site Number 152018, Santiago, Chile
Dept. of Oncology and Medical Physics, Haukeland University Hospital Bergen, Norway, Bergen, Norway
Department of General Surgery and Transplantation, Warsaw, Mazowieckie, Poland
Aarau Cantonal Hospital, Aarau, Switzerland
Inselspital - Bern University Hospital, Bern, Switzerland
Basel University Hospital, Basel, Switzerland
University of California Irvine-Department of Dermatology, Irvine, California, United States
Florida Academic Dermatology Center, Miami, Florida, United States
International Dermatology Research, Miami, Florida, United States
PV-Medical s.r.o., Zlin, Czech Republic
Ain Shams University/Al Demerdash Hospital/Diabetology Unit, Cairo, Egypt
New University Hospital, Alexandria Clinical Research Center, Alexandria, Al Iskandariyah, Egypt
G. Papanikolaoy, Thessaloniki, Exochi, Greece
"Olympion therapeutic center" General Clinic of Patras, Patras, Greece
424 Military Hospital, Thessaloniki, Thessalonikis, Greece
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