Overview
Selenious acid is the acid form of sodium selenite, a form of selenium . Selenium is an essential trace element and antioxidant. It is a cofactor metabolic enzyme regulation. It also plays an important role in maintaining the general health of tissue and muscle and has antioxidant properties. Selenium is a component of glutathione peroxidase enzyme, which protects cell components from oxidative damage due to peroxides produced during cellular metabolism . Selenium (Se) has been demonstrated to prevent cancer in numerous animal models when administered selenium at levels exceeding the nutritional requirements. One study showed efficacy in the prevention of malignancy while utilizing a selenium supplement in humans. The reports from such studies have heightened the interest in additional human selenium supplementation studies to validate the results in larger populations . Interestingly, selenium is being studied as a potential therapy in the prevention or management of atherosclerosis .
Indication
Selenium injection is indicated for use as a supplement to intravenous solutions given for total parenteral nutrition (TPN). Administration of selenious acid in TPN formulas helps to maintain plasma selenium levels and also to maintain endogenous stores to prevent deficiency . Selenium compounds, such as selenium sulfide, are used topically in anti-dandruff shampoos and in cases of seborrhea . For the purpose of brevity, selenite will the focus of discussion, and more information about selenium can be obtained at Selenium.
Associated Conditions
- Selenium Deficiency
Clinical Trials
Title | Posted | Study ID | Phase | Status | Sponsor |
|---|---|---|---|---|---|
2024/05/14 | Not Applicable | Not yet recruiting | All India Institute of Medical Sciences, Bhubaneswar | ||
2024/04/12 | Phase 4 | Not yet recruiting | |||
2023/11/07 | Phase 2 | Completed | |||
2022/03/04 | Phase 4 | Completed | |||
2021/06/28 | Not Applicable | UNKNOWN | Beijing Chao Yang Hospital | ||
2021/05/03 | Phase 2 | UNKNOWN | |||
2021/04/08 | Not Applicable | UNKNOWN | |||
2020/12/24 | Phase 4 | Not yet recruiting | Qianfoshan Hospital | ||
2020/12/10 | Phase 4 | Completed | Chang Gung Memorial Hospital | ||
2019/12/17 | Phase 3 | Active, not recruiting |
FDA Drug Approvals
Approved Product | Manufacturer | NDC Code | Route | Strength | Effective Date |
|---|---|---|---|---|---|
| Newton Laboratories, Inc. | 55714-2596 | ORAL | 15 [hp_X] in 1 mL | 5/21/2025 | |
| PureTek Corporation | 59088-193 | ORAL | 55 ug in 1 1 | 1/11/2023 | |
| Newton Laboratories, Inc. | 55714-4862 | ORAL | 15 [hp_X] in 1 mL | 5/21/2025 | |
| Novian Pharmaceuticals | 83146-003 | ORAL | 55 ug in 1 1 | 10/6/2023 | |
| American Regent, Inc. | 0517-8510 | INTRAVENOUS | 32.7 ug in 1 mL | 4/25/2019 | |
| Exeltis USA, Inc. | 0642-0207 | ORAL | 100 ug in 1 1 | 1/2/2023 | |
| PureTek Corporation | 59088-166 | ORAL | 70 ug in 1 1 | 2/8/2023 | |
| PureTek Corporation | 59088-180 | ORAL | 30 ug in 1 1 | 1/11/2023 | |
| PureTek Corporation | 59088-187 | ORAL | 55 ug in 1 1 | 1/11/2023 | |
| American Regent, Inc. | 0517-9302 | INTRAVENOUS | 9.8 ug in 1 mL | 7/9/2021 |
EMA Drug Approvals
Approved Product | Authorization Holder | Status | Issued Date |
|---|---|---|---|
| No EMA approvals found for this drug. | |||
HSA Drug Approvals
Approved Product | Manufacturer | Approval Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| Nutritrace Concentrate for solution for infusion | SIN14341P | INFUSION, SOLUTION CONCENTRATE | 0.0789mg/10ml | 4/22/2013 | |
| SELENIUM AGUETTANT CONCENTRATE FOR SOLUTION FOR INFUSION 10 MCG/ML | SIN16847P | INFUSION, SOLUTION CONCENTRATE | 10 mcg/mL | 8/27/2023 | |
| ADDAVEN CONCENTRATE FOR SOLUTION FOR INFUSION | SIN15302P | INFUSION, SOLUTION CONCENTRATE | 17.29 mcg/ml | 7/24/2017 | |
| PEDITRACE CONCENTRATE FOR PARENTERAL INFUSION | SIN08899P | INJECTION | 4.38 mcg/ml | 9/4/1996 |
NMPA Drug Approvals
Approved Product | Company | Approval Number | Drug Type | Dosage Form | Approval Date |
|---|---|---|---|---|---|
| No NMPA approvals found for this drug. | |||||
PPB Drug Approvals
Approved Product | Registration No. | Company | Licence No. | Strength | Registration Date |
|---|---|---|---|---|---|
| No PPB approvals found for this drug. | |||||
TGA Drug Approvals
Approved Product | ARTG ID | Sponsor | Registration Type | Status | Registration Date |
|---|---|---|---|---|---|
| MULTI VITAMIN & MINERAL CHELATION FORMULA tablet bulk | 60798 | Remedial Sciences International Pty Ltd | Medicine | A | 7/22/1997 |
| Hair Assist Women's Foam | 400972 | Medicine | A | 12/12/2022 | |
| LIBIDO PLUS + | 425111 | Medicine | A | 10/12/2023 | |
| Clements Energy and Focus | 280109 | Medicine | A | 9/9/2016 | |
| HAIR ASSIST | 115642 | Medicine | A | 1/14/2005 | |
| Health Right Australia Multivitamin | 355498 | Medicine | A | 2/24/2021 | |
| Hair Assist Men's Foam | 400970 | Medicine | A | 12/12/2022 | |
| Cerebrum compositum | 93564 | Medicine | A | 3/20/2003 | |
| Vitamin C with Hesperidin Complex | 159838 | Medicine | A | 3/6/2009 |
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