Zidovudine
- Generic Name
- Zidovudine
- Brand Names
- Combivir, Retrovir, Trizivir
- Drug Type
- Small Molecule
- Chemical Formula
- C10H13N5O4
- CAS Number
- 30516-87-1
- Unique Ingredient Identifier
- 4B9XT59T7S
- Background
A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during reverse transcription. It improves immunologic function, partially reverses the HIV-induced neurological dysfunction, and improves certain other clinical abnormalities associated with AIDS. Its principal toxic effect is dose-dependent suppression of bone marrow, resulting in anemia and leukopenia. [PubChem]
- Indication
Used in combination with other antiretroviral agents for the treatment of human immunovirus (HIV) infections.
- Associated Conditions
- HIV Transmission, Human Immunodeficiency Virus (HIV) Infections, Perinatal HIV transmission
- Associated Therapies
- -
The Safety and Effectiveness of Injections of Human Recombinant Interferon-gamma in Patients With AIDS Who Have Taken Zidovudine
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2021-11-04
- Target Recruit Count
- 5
- Registration Number
- NCT00001112
- Locations
- 🇺🇸
Cornell University A2201, New York, New York, United States
Comparison of Three Anti-HIV Drug Combinations in HIV-Infected Patients With No Symptoms of the Disease
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2021-11-04
- Target Recruit Count
- 300
- Registration Number
- NCT00001045
- Locations
- 🇺🇸
St Paul Ramsey Med Ctr, Saint Paul, Minnesota, United States
🇺🇸Adirondack Med Ctr at Saranac Lake, Albany, New York, United States
🇺🇸Mid - Hudson Care Ctr, Albany, New York, United States
A Phase I Study of the Combination of Recombinant GM-CSF, AZT, and Chemotherapy (ABV) (Adriamycin, Bleomycin, Vincristine) in AIDS and Kaposi's Sarcoma
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2021-11-03
- Target Recruit Count
- 24
- Registration Number
- NCT00000681
- Locations
- 🇺🇸
UCLA CARE Center CRS, Los Angeles, California, United States
🇺🇸Pitt CRS, Pittsburgh, Pennsylvania, United States
🇺🇸SUNY - Buffalo, Erie County Medical Ctr., Buffalo, New York, United States
The Safety and Effectiveness of Zidovudine Plus Lamivudine, Used With and Without 1592U89, in HIV-1 Infected Children Who Have Taken Anti-HIV-1 Drugs
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2005-06-24
- Lead Sponsor
- Glaxo Wellcome
- Registration Number
- NCT00002391
- Locations
- 🇺🇸
Children's Hosp Los Angeles, Los Angeles, California, United States
🇺🇸Children's Diagnostic Treatment Ctr, Fort Lauderdale, Florida, United States
🇺🇸UMDNJ / Division of Allergy Immunology & Infectious Diseases, Newark, New Jersey, United States
Combination Treatment With and Without Protease Inhibitors for Women Who Begin Therapy for HIV Infection During Pregnancy
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2021-11-01
- Target Recruit Count
- 440
- Registration Number
- NCT00017719
- Locations
- 🇺🇸
Harbor - UCLA Med. Ctr. - Dept. of Peds., Div. of Infectious Diseases, Torrance, California, United States
🇺🇸WNE Maternal Pediatric Adolescent AIDS CRS, Worcester, Massachusetts, United States
🇺🇸Mt. Sinai Hosp. Med. Ctr. - Chicago, Womens & Childrens HIV Program, Chicago, Illinois, United States
A Phase I Study of Methotrexate for HIV Infection
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2021-10-29
- Target Recruit Count
- 30
- Registration Number
- NCT00000834
- Locations
- 🇺🇸
Cedars Sinai Med Ctr, Los Angeles, California, United States
🇺🇸Univ of Kansas School of Medicine, Wichita, Kansas, United States
🇺🇸Georgetown Univ Med Ctr, Washington, District of Columbia, United States
A Study on the Management of Combination Anti-HIV Drug Therapy in HIV-Positive Children With Prior Treatment
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2021-10-29
- Target Recruit Count
- 217
- Registration Number
- NCT00000902
- Locations
- 🇺🇸
Connecticut Children's Med Ctr, Farmington, Connecticut, United States
🇺🇸Cedars Sinai / UCLA Med Ctr, Los Angeles, California, United States
🇺🇸Harbor - UCLA Med Ctr / UCLA School of Medicine, Los Angeles, California, United States
Simplified Drug Regimens for HIV Patients in ACTG 388 or Patients Who Responded to A First Potent Combination Regimen
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2013-07-29
- Target Recruit Count
- 240
- Registration Number
- NCT00014937
- Locations
- 🇮🇹
Spedali Civili - Carosi, Brescia, Italy
🇺🇸Rush Presbyterian - Saint Luke's Med Ctr, Chicago, Illinois, United States
🇺🇸Univ of Southern California / LA County USC Med Ctr, Los Angeles, California, United States
A Double-Blind, Placebo-Controlled Trial To Evaluate Intravenous Gamma Globulin in Children With Symptomatic HIV Infection Receiving Zidovudine
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2021-11-03
- Target Recruit Count
- 250
- Registration Number
- NCT00000720
- Locations
- 🇺🇸
Los Angeles County - USC Med Ctr, Los Angeles, California, United States
🇺🇸Cedars Sinai / UCLA Med Ctr, Los Angeles, California, United States
🇺🇸Univ of Connecticut Health Ctr / Pediatrics, Farmington, Connecticut, United States
Comparison of New Anti-HIV Drug Combinations in HIV-Infected Children Who Have Taken Anti-HIV Drugs
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2021-11-04
- Target Recruit Count
- 240
- Registration Number
- NCT00001083
- Locations
- 🇺🇸
Harbor - UCLA Med Ctr / UCLA School of Medicine, Los Angeles, California, United States
🇺🇸Univ of Miami (Pediatric), Miami, Florida, United States
🇺🇸North Shore Univ Hosp, Great Neck, New York, United States
Drug Development Updates
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