Zidovudine
- Generic Name
- Zidovudine
- Brand Names
- Combivir, Retrovir, Trizivir
- Drug Type
- Small Molecule
- Chemical Formula
- C10H13N5O4
- CAS Number
- 30516-87-1
- Unique Ingredient Identifier
- 4B9XT59T7S
- Background
A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during reverse tran...
- Indication
Used in combination with other antiretroviral agents for the treatment of human immunovirus (HIV) infections.
- Associated Conditions
- HIV Transmission, Human Immunodeficiency Virus (HIV) Infections, Perinatal HIV transmission
- Associated Therapies
- -
Safety and Pharmacokinetic Study of Fixed Dose Combination of Zidovudine, Lamivudine, and Nevirapine in HIV-Infected Children in Thailand
- Conditions
- Interventions
- First Posted Date
- 2008-05-06
- Last Posted Date
- 2021-11-09
- Target Recruit Count
- 42
- Registration Number
- NCT00672412
- Locations
- ๐น๐ญ
Prapokklao Hosp. CRS, Muang District, Chantaburi, Thailand
๐น๐ญSiriraj Hospital Mahidol University CRS, Bangkok, Ratchathewi, Thailand
๐น๐ญChonburi Hosp. CRS, Chonburi, Thailand
Determining the Effects of Observed and Self-Administered Drug Regimens in HIV Infected Adults
- Conditions
- Interventions
- First Posted Date
- 2008-02-06
- Last Posted Date
- 2018-10-12
- Target Recruit Count
- 529
- Registration Number
- NCT00608569
- Locations
- ๐บ๐ฌ
JCRC CRS, Kampala, Uganda
๐ญ๐นLes Centres GHESKIO CRS, Bicentenaire, Port-au-Prince, Haiti
๐ต๐ชBarranco CRS, Lima, Peru
Bioequivalency Study of Zidovudine Under Fasting Conditions
- Conditions
- First Posted Date
- 2008-01-28
- Last Posted Date
- 2018-01-23
- Lead Sponsor
- Roxane Laboratories
- Target Recruit Count
- 52
- Registration Number
- NCT00602550
- Locations
- ๐บ๐ธ
CEDRA Clinical Research, Austin, Texas, United States
Bioequivalency Study of Zidovudine Under Fed Conditions
- Conditions
- First Posted Date
- 2008-01-28
- Last Posted Date
- 2018-01-23
- Lead Sponsor
- Roxane Laboratories
- Target Recruit Count
- 52
- Registration Number
- NCT00601562
- Locations
- ๐บ๐ธ
CEDRA Clinical Research, LLC, Austin, Texas, United States
Safety and Efficacy of Switching From Stavudine or Zidovudine to Tenofovir DF in HIV-1 Infected Children
- Conditions
- Interventions
- First Posted Date
- 2007-09-14
- Last Posted Date
- 2018-03-14
- Lead Sponsor
- Gilead Sciences
- Target Recruit Count
- 97
- Registration Number
- NCT00528957
- Locations
- ๐ต๐ฆ
Hospital del Nino, Panama City, Panama
๐บ๐ธSt. Jude Children's Research Hospital, Memphis, Tennessee, United States
๐บ๐ธChildren's Diagnostic and Treatment Center, Inc, Fort Lauderdale, Florida, United States
Safety, Tolerance, Pharmacokinetic and Antiviral Study of Amdoxovir in Combination With Zidovudine in Adults With HIV
- Conditions
- First Posted Date
- 2007-02-06
- Last Posted Date
- 2007-05-11
- Lead Sponsor
- RFS Pharma, LLC
- Target Recruit Count
- 24
- Registration Number
- NCT00432016
- Locations
- ๐ฆ๐ท
Hospital Privado Modelo, Buenos Aires, Argentina
Maternal/Infant Peripartum NVP, Versus Infant Only Peripartum NVP, or Maternal LPV/r in Addition to Standard ZDV Prophylaxis for the Prevention of Perinatal (PMTCT) HIV in Thailand
- Conditions
- Interventions
- First Posted Date
- 2006-12-11
- Last Posted Date
- 2016-01-28
- Lead Sponsor
- Institut de Recherche pour le Developpement
- Target Recruit Count
- 435
- Registration Number
- NCT00409591
- Locations
- ๐น๐ญ
Bhumibol Adulyadej Hospital, Saimai, Bangkok, Thailand
๐น๐ญNopparat Rajathanee Hospital, Kannayao, Bangkok, Thailand
๐น๐ญBanglamung Hospital, Banglamung, Chonburi, Thailand
Antiretroviral Therapy for Advanced HIV Disease in South Africa
- Conditions
- Interventions
- First Posted Date
- 2006-06-21
- Last Posted Date
- 2013-05-21
- Target Recruit Count
- 1771
- Registration Number
- NCT00342355
- Locations
- ๐ฟ๐ฆ
Mtubatuba SIckbay, Kwazulu-Natal, South Africa
๐ฟ๐ฆUmtata Sickbay, Eastaern Cape, South Africa
๐ฟ๐ฆSouth African Military Health Services (SAMHS), Centurion, South Africa
Antiviral Responses to NNRTI-Based vs. PI-Based ARV Therapy in HIV Infected Infants Who Have or Have Not Received Single Dose NVP for Prevention of Mother-to-Child Transmission of HIV
- Conditions
- Interventions
- First Posted Date
- 2006-03-27
- Last Posted Date
- 2017-04-13
- Target Recruit Count
- 452
- Registration Number
- NCT00307151
- Locations
- ๐ฟ๐ฒ
George Clinic CRS, Lusaka, Zambia
๐ฟ๐ผUZ-College of Health Sciences, Harare, Zimbabwe
๐ฎ๐ณBJ Medical College CRS, Pune, Maharashtra, India
Trial to Evaluate Steady State Pharmacokinetic Parameters, Efficacy and Safety of Nevirapine in Antiretroviral Drug naรฏve Pediatric Patients
- Conditions
- First Posted Date
- 2006-01-10
- Last Posted Date
- 2013-10-31
- Lead Sponsor
- Boehringer Ingelheim
- Target Recruit Count
- 123
- Registration Number
- NCT00273975
- Locations
- ๐ฟ๐ฆ
Boehringer Ingelheim Investigational Site, Tygerberg, South Africa
๐ฟ๐ฆGroote Schuur Hospital, Cape Town, South Africa
Drug Development Updates
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