Terlipressin
- Generic Name
- Terlipressin
- Brand Names
- Terlivaz
- Drug Type
- Biotech
- Chemical Formula
- -
- CAS Number
- 14636-12-5
- Unique Ingredient Identifier
- 7Z5X49W53P
- Background
Terlipressin is a synthetic analogue of vasopressin, which is an endogenous neurohormone that acts as a vasoconstrictor. It is a prodrug of lypressin, or lysine vasopressin. Compared to endogenous vasopressin, terlipressin has a longer half life and increased selectivity for the V1 receptor. As a potent vasopressor, terlipressin has been investigated in vari...
- Indication
Terlipressin is a vasopressin receptor agonist indicated to improve kidney function in adults with hepatorenal syndrome with rapid reduction in kidney function. The US prescribing information states that patients with a serum creatinine > 5 mg/dL are unlikely to experience benefit from terlipressin.
- Associated Conditions
- Hepato-Renal Syndrome, Hepatorenal Syndrome Type 1, Oesophageal varices haemorrhage, Portal Hypertension
- Associated Therapies
- -
ACid Tranexamic or Terlipressin for Initial Emergency Treatment of Mild to seVere hEmoptysis: a Randomized Trial.
- Conditions
- Interventions
- First Posted Date
- 2021-07-14
- Last Posted Date
- 2024-05-03
- Lead Sponsor
- Assistance Publique - Hôpitaux de Paris
- Target Recruit Count
- 315
- Registration Number
- NCT04961528
- Locations
- 🇫🇷
AP-HP, Hôpital Européen Georges Pompidou, Paris, France
Comparison of Bolus Versus Continuous Infusion of Terlipressin Cirrhotic Patients With Septic Shock.
- First Posted Date
- 2021-03-29
- Last Posted Date
- 2021-11-10
- Lead Sponsor
- Institute of Liver and Biliary Sciences, India
- Target Recruit Count
- 310
- Registration Number
- NCT04819568
- Locations
- 🇮🇳
Institute of Liver & Biliary Sciences, New Delhi, Delhi, India
Terlipressin for HRS-AKI in Liver Transplant Candidates (INFUSE)
- First Posted Date
- 2020-07-07
- Last Posted Date
- 2024-10-09
- Lead Sponsor
- University of Pennsylvania
- Target Recruit Count
- 50
- Registration Number
- NCT04460560
- Locations
- 🇺🇸
Baylor Scott and White All Saints Medical Center, Fort Worth, Texas, United States
🇺🇸University of Pennsylvania, Philadelphia, Pennsylvania, United States
🇺🇸Piedmont Healthcare, Inc, Atlanta, Georgia, United States
Efficacy of Early Terlipressin Plus Albumin Therapy in Comparison to Standard Treatment for HRS-AKI in Acute-on-chronic Liver Failure.
- Conditions
- Interventions
- First Posted Date
- 2020-06-04
- Last Posted Date
- 2023-04-06
- Lead Sponsor
- Institute of Liver and Biliary Sciences, India
- Target Recruit Count
- 70
- Registration Number
- NCT04416282
- Locations
- 🇮🇳
Institute of Liver & Biliary Sciences, New Delhi, Delhi, India
Terlipression Prevent Developing of Acute Kidney Injury During Upper-gastroentestinal Bleeding
- Conditions
- Interventions
- First Posted Date
- 2020-04-22
- Last Posted Date
- 2020-04-22
- Lead Sponsor
- Changhai Hospital
- Target Recruit Count
- 54
- Registration Number
- NCT04358016
- Locations
- 🇨🇳
Changhai hospital, Shanghai, China
Hemodynamic Profile of Terlipressin and Octreotide in Patients With Cirrhosis and Portal Hypertension. A Randomised, Single Blinded Clinical Trial.
- First Posted Date
- 2020-04-20
- Last Posted Date
- 2020-04-20
- Lead Sponsor
- Juan A. Arnaiz
- Target Recruit Count
- 36
- Registration Number
- NCT04353193
- Locations
- 🇪🇸
Hospital Clinic, Barcelona, Spain
Terlipressin for Refractory Septic Shock
- Conditions
- Interventions
- First Posted Date
- 2020-04-09
- Last Posted Date
- 2021-09-24
- Lead Sponsor
- Mahidol University
- Target Recruit Count
- 130
- Registration Number
- NCT04339868
- Locations
- 🇹🇭
Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
Functional MRI-based Assessment of Terlipressin vs. Octreotide on Renal Function in Cirrhotic Patients With Acute Variceal Bleeding (CHESS1903)
- Conditions
- Interventions
- First Posted Date
- 2019-07-22
- Last Posted Date
- 2021-08-17
- Lead Sponsor
- Nanfang Hospital, Southern Medical University
- Target Recruit Count
- 60
- Registration Number
- NCT04028323
- Locations
- 🇨🇳
The First Hospital of Lanzhou University, Lanzhou, Gansu, China
🇨🇳The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China
🇨🇳Guangdong Second Provincial General Hospital, Guangzhou, Guangdong, China
Terlipressin on Effect of Renal Function in Cirrhotic Patients With Acute Gastrointestinal Hemorrhage
- Conditions
- Interventions
- First Posted Date
- 2019-02-19
- Last Posted Date
- 2019-07-05
- Lead Sponsor
- General Hospital of Shenyang Military Region
- Target Recruit Count
- 1682
- Registration Number
- NCT03846180
- Locations
- 🇨🇳
Department of Gastroenterology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China
🇨🇳Department of Gastroenterology, Air Force Hospital of Northern Theater Command, Shenyang, Liaoning, China
🇨🇳Department of Gastroenterology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, China
Terlipressin Infusion Alone Vs Terlipressin With Noradrenaline Infusion In The Treatment of Hepatorenal Syndrome Type 1
- Conditions
- Interventions
- First Posted Date
- 2019-01-30
- Last Posted Date
- 2023-05-09
- Target Recruit Count
- 60
- Registration Number
- NCT03822091
- Locations
- 🇮🇳
Post Graduate Institute of Medical Education and Research, Chandigarh, India
Drug Development Updates
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