Terlipressin

Generic Name: Terlipressin

Brand Names: Terlivaz

Drug Type: Biotech

Chemical Formula: -

CAS Number: 14636-12-5

Unique Ingredient Identifier: 7Z5X49W53P

Background: Terlipressin is a synthetic analogue of vasopressin, which is an endogenous neurohormone that acts as a vasoconstrictor. It is a prodrug of lypressin, or lysine vasopressin. Compared to endogenous vasopressin, terlipressin has a longer half life and increased selectivity for the V1 receptor. As a potent vasopressor, terlipressin has been investigated in vari...

Indication: Terlipressin is a vasopressin receptor agonist indicated to improve kidney function in adults with hepatorenal syndrome with rapid reduction in kidney function. The US prescribing information states that patients with a serum creatinine > 5 mg/dL are unlikely to experience benefit from terlipressin.

Associated Conditions: Hepato-Renal Syndrome, Hepatorenal Syndrome Type 1, Oesophageal varices haemorrhage, Portal Hypertension

Associated Therapies: -

Clinical Trials

Efficacy of Terlipressin Therapy in Acute Variceal Haemorrhage After EVL

Phase 4

Completed

Conditions: Acute Variceal Haemorrhage

Interventions: Drug: Normal Saline
Drug: Terlipressin

First Posted Date: 2018-07-12

Last Posted Date: 2019-12-16

Lead Sponsor: Post Graduate Institute of Medical Education and Research, Chandigarh

Target Recruit Count: 74

Registration Number: NCT03584087

Locations: 🇮🇳
Post Graduate Institute of Medical Education and Research, Chandigarh, India

Terlipressin Infusion During Whipple Procedure: Effect on Blood Loss and Transfusion Needs

Phase 2

Completed

Conditions: Terlipressin
Blood Loss

Interventions: Drug: normal saline
Drug: Terlipressin

First Posted Date: 2018-06-28

Last Posted Date: 2023-05-22

Lead Sponsor: Assiut University

Target Recruit Count: 40

Registration Number: NCT03572088

Effects of Terlipressin on Management of Potential Organ Donors

Completed

Conditions: Organ Donors

Interventions: Drug: terlipressin

First Posted Date: 2018-03-26

Last Posted Date: 2018-03-26

Lead Sponsor: First Affiliated Hospital, Sun Yat-Sen University

Target Recruit Count: 18

Registration Number: NCT03477461

Effect of Terlipressin on Cerebral Oxygen Saturation During Liver Transplantation

Phase 2

Completed

Conditions: Terlipressin Adverse Reaction
Liver Transplantation

Interventions: Drug: Terlipressin
Drug: Normal saline

First Posted Date: 2018-01-10

Last Posted Date: 2018-12-24

Lead Sponsor: Kasr El Aini Hospital

Target Recruit Count: 30

Registration Number: NCT03395574

Locations: 🇪🇬
Kasr Alainy Hospital , Faculty of Medicine, Cairo, Egypt

Effect of Terlipressinum on the Portal Vein Pressure of Patients With Liver Tumor After Liver Resection

Phase 2

Conditions: Portal Vein Pressure

Interventions: Drug: Terlipressinum

First Posted Date: 2017-11-24

Last Posted Date: 2017-11-24

Lead Sponsor: Shanghai Zhongshan Hospital

Target Recruit Count: 30

Registration Number: NCT03352349

Locations: 🇨🇳
Zhongshan Hospital, Shanghai, Shanghai, China

Evaluation of Early Association of Terlipressin and Norepinephrine During Septic Shock; the TerliNor Study

Phase 4

Conditions: Septic Shock

Interventions: Other: Placebo
Drug: Terlipressin

First Posted Date: 2017-11-08

Last Posted Date: 2018-11-29

Lead Sponsor: Assistance Publique Hopitaux De Marseille

Target Recruit Count: 40

Registration Number: NCT03336814

Locations: 🇫🇷
Assistance Publique - Hôpitaux de Marseille, Marseille Cedex 05, France

Efficacy and Safety of Terlipressin With Albumin Versus Midodrine With Albumin Versus Albumin Alone in Prevention of Paracentesis Induced Circulatory Dysfunction in Cirrhosis

Not Applicable

Completed

Conditions: Cirrhosis

Interventions: Drug: Albumin
Drug: Terlipressin
Drug: Midodrine

First Posted Date: 2017-05-09

Last Posted Date: 2018-09-05

Lead Sponsor: Institute of Liver and Biliary Sciences, India

Target Recruit Count: 150

Registration Number: NCT03144713

Locations: 🇮🇳
Institute of Liver and Biliary Sciences, New Delhi, Delhi, India

Continuous Versus Bolus Infusion of Terlipressin for Portal Hypertension Related Bleeding in Liver Cirrhosis

Not Applicable

Not yet recruiting

Conditions: Portal Hypertension
Variceal Hemorrhage
Bleeding
Liver Cirrhosis
Esophageal and Gastric Varices

Interventions: Drug: Terlipressin

First Posted Date: 2017-04-26

Last Posted Date: 2024-02-23

Lead Sponsor: General Hospital of Shenyang Military Region

Target Recruit Count: 40

Registration Number: NCT03130127

What Should be the Next Vasopressor for Severe Septic Shock? Methylene Blue or Terlipressin

Phase 3

Conditions: Septic Shock
Refractory Shock

Interventions: Drug: Methylene Blue
Drug: Terlipressin

First Posted Date: 2017-01-31

Last Posted Date: 2018-08-29

Lead Sponsor: Ramathibodi Hospital

Target Recruit Count: 60

Registration Number: NCT03038503

Locations: 🇹🇭
Ramathibodi hospital, Bangkok, Thailand

Study To Confirm Efficacy and Safety of Terlipressin in Hepatorenal Syndrome (HRS) Type 1

Phase 3

Completed

Conditions: Hepatorenal Syndrome

Interventions: Drug: Terlipressin
Other: Placebo

First Posted Date: 2016-05-12

Last Posted Date: 2022-11-29

Lead Sponsor: Mallinckrodt

Target Recruit Count: 300

Registration Number: NCT02770716

Locations: 🇺🇸
Mercy Medical Center, Baltimore, Maryland, United States
🇺🇸
Drexel University, Philadelphia, Pennsylvania, United States
🇺🇸
Baylor University Medical Center, Dallas, Texas, United States

and more 61 locations

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