Sugammadex

Generic Name: Sugammadex

Brand Names: Bridion, Sugammadex Adroiq, Sugammadex Amomed, Sugammadex Fresenius Kabi, Sugammadex Mylan, Sugammadex Piramal

Drug Type: Small Molecule

Chemical Formula: C_₇₂H_₁₁₂O_₄₈S_₈

CAS Number: 343306-71-8

Unique Ingredient Identifier: 361LPM2T56

Background: Sugammadex is a selective relaxant binding agent indicated for reversal of neuromuscular blockade induced by rocuronium bromide and vecuronium bromide during surgery. Rocuronium bromide and vecuronium bromide are neuromuscular blocking medications that cause temporary paralysis and are especially useful for general anesthesia, ventilation, or tracheal intubation that patients may require for surgery. Sugammadex provides a new treatment option to reverse the effects of those medications and possibly help patients recover sooner post-surgery. Sugammadex (brand name Bridion) is marketed by Merck Sharp and Dohme, and was approved by the United States FDA on December 15, 2015.

Indication: Sugammadex is indicated for the reversal of neuromuscular blockade induced by rocuronium bromide or vecuronium bromide in adults and pediatric patients ≥2 years old who are undergoing surgery.

Associated Conditions: Neuromuscular blockade caused by vecuronium bromide

Clinical Trials

Using Diaphragm Ultrasonography, Sugammadex Recovers Diaphragmatic Function More Effectively Than Neostigmine.

Phase 1

Completed

Conditions: Perioperative Diaphragmatic Function

Interventions: Drug: sugammadex
Drug: Neostigmine

First Posted Date: 2025-05-21

Last Posted Date: 2025-05-21

Lead Sponsor: Ain Shams University

Target Recruit Count: 60

Registration Number: NCT06982092

Locations: 🇪🇬
faculty of medicine, ain shams University, Cairo, Egypt

Recovery Times of Half Dose Sugammadex and Neostigmine for Rocuronium-induced Neuromuscular Blockade

Phase 1

Recruiting

Conditions: Neuromuscular Blocking Agents
Reversal of Neuromuscular Blockade
Recovery Time

Interventions: Drug: Sugammadex 1 mg/kg
Drug: Neostigmine + Atropine

First Posted Date: 2025-01-27

Last Posted Date: 2025-01-28

Lead Sponsor: Universitas Padjadjaran

Target Recruit Count: 60

Registration Number: NCT06794450

Locations: 🇮🇩
Hasan Sadikin General Hospital, Bandung, Jawa Barat, Indonesia

Sugammadex on Laparoscopic Bariatric Surgery

Not Applicable

Not yet recruiting

Conditions: Laparoscopic Bariatric Surgery
Sugammadex

Interventions: Drug: Sugammadex
Drug: Neostigmine

First Posted Date: 2024-11-07

Last Posted Date: 2024-11-07

Lead Sponsor: Shanxi Bethune Hospital

Target Recruit Count: 60

Registration Number: NCT06678451

Placental Transfer of Sugammadex in the Human Placental Perfusion Model

Not Applicable

Conditions: Pregnancy

Interventions: Drug: Sugammadex

First Posted Date: 2024-10-09

Last Posted Date: 2025-03-25

Lead Sponsor: Universitaire Ziekenhuizen KU Leuven

Target Recruit Count: 16

Registration Number: NCT06634355

Locations: 🇧🇪
UZ Leuven, Leuven, Vlaams-Brabant, Belgium

Sugammadex and Time to Extubation in Ophthalmic Surgery

Completed

Conditions: General Anesthesia Using Endotracheal Intubation
Ophthalmologic Surgical Procedure
Sugammadex
Neostigmine
Extubation Readiness

Interventions: Drug: sugammadex
Drug: Neostigmine + Atropine

First Posted Date: 2024-10-08

Last Posted Date: 2024-10-08

Lead Sponsor: China Medical University Hospital

Target Recruit Count: 262

Registration Number: NCT06632067

Locations: 🇨🇳
China Medical University Hospital, Taichung, Taiwan

Sugammadex Dose Finding Under Two Years Old

Phase 2

Not yet recruiting

Conditions: Neuromuscular Blockade

Interventions: Drug: Sugammadex

First Posted Date: 2024-08-28

Last Posted Date: 2024-08-29

Lead Sponsor: Sang-Hwan Ji

Target Recruit Count: 33

Registration Number: NCT06575036

Locations: 🇰🇷
Seoul National University Hospital, Seoul, Korea, Republic of

The Influence Factors of Bispectral Index Values Increment Caused by Sugammadex

Not yet recruiting

Conditions: BIS

First Posted Date: 2024-08-20

Last Posted Date: 2024-08-21

Lead Sponsor: Jun Zhang

Target Recruit Count: 135

Registration Number: NCT06561633

Locations: 🇨🇳
Fudan University Shanghai Cancer Center, Shanghai, Shanghai, China

Efficacy and Safety of Sugammadex in Thoracoscopy Thymectomy for Chinese Adults With Myasthenia Gravis

Not Applicable

Completed

Conditions: Reversal of Neuromuscular Blockade

Interventions: Drug: Sugammadex
Drug: Neostigmine

First Posted Date: 2024-05-31

Last Posted Date: 2025-04-02

Lead Sponsor: Beijing Tongren Hospital

Target Recruit Count: 62

Registration Number: NCT06436768

Locations: 🇨🇳
Beijing tongren Hospital, Capital Medical University, Beijing, Beijing, China
🇨🇳
The First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu, China