Sugammadex

Generic Name: Sugammadex

Brand Names: Bridion, Sugammadex Adroiq, Sugammadex Amomed, Sugammadex Fresenius Kabi, Sugammadex Mylan, Sugammadex Piramal

Drug Type: Small Molecule

Chemical Formula: C_₇₂H_₁₁₂O_₄₈S_₈

CAS Number: 343306-71-8

Unique Ingredient Identifier: 361LPM2T56

Background: Sugammadex is a selective relaxant binding agent indicated for reversal of neuromuscular blockade induced by rocuronium bromide and vecuronium bromide during surgery. Rocuronium bromide and vecuronium bromide are neuromuscular blocking medications that cause temporary paralysis and are especially useful for general anesthesia, ventilation, or tracheal intuba...

Indication: Sugammadex is indicated for the reversal of neuromuscular blockade induced by rocuronium bromide or vecuronium bromide in adults and pediatric patients ≥2 years old who are undergoing surgery.

Associated Conditions: Neuromuscular blockade caused by vecuronium bromide

Associated Therapies: -

Clinical Trials

The Effect of Sugammadex During Transcranial Electrical Motor Evoked Potential Monitoring in Spinal Surgery

Not Applicable

Completed

Conditions: Sugammadex

Interventions: Drug: Sugammadex

First Posted Date: 2020-07-15

Last Posted Date: 2021-04-06

Lead Sponsor: Beijing Tiantan Hospital

Target Recruit Count: 66

Registration Number: NCT04471376

Locations: 🇨🇳
Beijing Tiantan Hospital, Beijing, China

Comparison of QoR-15 in Laparoscopic Cholecystectomy: Sugammadex vs. Neostigmine

Phase 4

Completed

Conditions: Neuromuscular Blockade Reversal Agent
Sugammadex
Quality of Recovery
Laparoscopic Cholecystectomy
Neostigmine

Interventions: Drug: Sugammadex
Drug: Neostigmine

First Posted Date: 2020-04-02

Last Posted Date: 2020-12-24

Lead Sponsor: Seoul National University Bundang Hospital

Target Recruit Count: 77

Registration Number: NCT04332627

Locations: 🇰🇷
Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, Korea, Republic of

Deep vs Moderate Neuromuscular Blocks on Remifentanil for Laparoscopic Gastrectomy

Not Applicable

Completed

Conditions: Gastric Cancer

Interventions: Drug: Neostigmine + glycopyrate
Drug: Sugammadex

First Posted Date: 2019-12-19

Last Posted Date: 2020-12-17

Lead Sponsor: Ajou University School of Medicine

Target Recruit Count: 120

Registration Number: NCT04205097

Locations: 🇰🇷
Department of Anesthesiology and Pain Medicine, Ajou University School of Medicine, Suwon, Gyeonggido, Korea, Republic of

Pharmacokinetics and Pharmacodynamics of Sugammadex in Reversal of Vecuronium-induced Neuromuscular Blockade

Phase 4

Conditions: Pharmacodynamics
Pharmacokinetics

Interventions: Drug: Sugammadex

First Posted Date: 2019-10-18

Last Posted Date: 2020-03-31

Lead Sponsor: Guangzhou General Hospital of Guangzhou Military Command

Target Recruit Count: 20

Registration Number: NCT04131218

Locations: 🇨🇳
Guangzhou Military Region General Hospital, Department of Anesthesiology, Guangzhou, Guangdong, China

Efficacy and Safety of Sugammadex in High-Risk Ambulatory Surgeries

Phase 4

Withdrawn

Conditions: Ambulatory Difficulty

Interventions: Drug: Neostigmine
Drug: Sugammadex

First Posted Date: 2019-05-09

Last Posted Date: 2019-11-18

Lead Sponsor: Montefiore Medical Center

Registration Number: NCT03944473

Role of Sugammadex as Reversal Agent in Patients Extubated Immediately After Isolated Coronary Artery Bypass Grafting Surgery

Phase 4

Completed

Conditions: Surgery
Coronary Artery Disease

Interventions: Drug: Rocuronium
Drug: Neostigmine
Drug: Sugammadex
Drug: Glycopyrrolate

First Posted Date: 2019-05-07

Last Posted Date: 2023-12-27

Lead Sponsor: West Virginia University

Target Recruit Count: 84

Registration Number: NCT03939923

Locations: 🇺🇸
WVU Medicine, Morgantown, West Virginia, United States

Sugammadex Versus Neostigmine for Reversal of Neuromuscular Blockade at the End of Kidney Transplantation Surgery

Phase 4

Completed

Conditions: Kidney Transplant; Complications
Postoperative Residual Curarization
Postoperative Residual Weakness

Interventions: Drug: Sugammadex
Drug: Neostigmine

First Posted Date: 2019-04-22

Last Posted Date: 2024-06-26

Lead Sponsor: University of Colorado, Denver

Target Recruit Count: 84

Registration Number: NCT03923556

Locations: 🇺🇸
University of Colorado Hospital, Aurora, Colorado, United States

The Improvement of Intraoperative Neuromonitoring of Recurrent Laryngeal Nerve

Not Applicable

Completed

Conditions: Thyroid Intra-Operative Injury

Interventions: Drug: sugammadex

First Posted Date: 2019-04-11

Last Posted Date: 2021-06-30

Lead Sponsor: Kaohsiung Medical University Chung-Ho Memorial Hospital

Target Recruit Count: 60

Registration Number: NCT03911232

Locations: 🇨🇳
I-Cheng Lu, Kaohsiung, Taiwan

Deep Neuromuscular Relaxation Optimizing Low-Pressure Bariatric Surgery

Not Applicable

Conditions: Bariatric Surgery

Interventions: Procedure: Deep Neuromuscular Blockade
Drug: Sugammadex

First Posted Date: 2019-01-15

Last Posted Date: 2019-01-15

Lead Sponsor: McMaster University

Target Recruit Count: 100

Registration Number: NCT03803982

Effect of Rocuronium and Sugammadex Under Sevoflurane and Desflurane Anesthesia in Children

Not Applicable

Completed

Conditions: Anesthetics, Inhalation
Neuromuscular Blockade
Anesthesia, General

Interventions: Drug: Rocuronium
Drug: Sugammadex

First Posted Date: 2019-01-07

Last Posted Date: 2021-05-04

Lead Sponsor: Istanbul University

Target Recruit Count: 148

Registration Number: NCT03795259

Locations: 🇹🇷
Istanbul University Cerrahpasa Medical Faculty, Istanbul, Please Select, Turkey

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