Carbinoxamine
- Generic Name
- Carbinoxamine
- Brand Names
- Karbinal, Ryvent
- Drug Type
- Small Molecule
- Chemical Formula
- C16H19ClN2O
- CAS Number
- 486-16-8
- Unique Ingredient Identifier
- 982A7M02H5
Overview
Carbinoxamine is a first generation antihistamine that competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding. The product label for carbinoxamine as an over the counter cough and cold medicine is being modified to state "do not use" in children under 4 years of age in order to prevent and reduce misuse, as many unapproved carbinoxamine-containing preparations contained inappropriate labeling, which promoted unapproved uses (including management of congestion, cough, the common cold, and the use in children under 2 years of age), which can potentially cause serious health risks.
Background
Carbinoxamine is a first generation antihistamine that competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding. The product label for carbinoxamine as an over the counter cough and cold medicine is being modified to state "do not use" in children under 4 years of age in order to prevent and reduce misuse, as many unapproved carbinoxamine-containing preparations contained inappropriate labeling, which promoted unapproved uses (including management of congestion, cough, the common cold, and the use in children under 2 years of age), which can potentially cause serious health risks.
Indication
For symptomatic relief of seasonal and perennial allergic rhinitis and vasomotor rhinitis, as well as allergic conjunctivitis caused by foods and inhaled allergens. Also for the relief of allergic reactions to blood or plasma, and the symptomatic management of mild, uncomplicated allergic skin manifestations of urticaria and angioedema.
Associated Conditions
- Allergic Conjunctivitis (AC)
- Allergic Reaction
- Allergic Rhinitis (AR)
- Anaphylaxis
- Angioedema
- Urticaria
- Vasomotor Rhinitis
- Dermatographism
Clinical Trials
Title | Posted | Study ID | Phase | Status | Sponsor |
|---|
No clinical trials found
No clinical trials found for this drug
FDA Approved Products
Product Name | Manufacturer | Route | Strength | Approved | NDC Code |
|---|---|---|---|---|---|
ORAL | 6 mg in 1 1 | 2024/03/26 | 69067-240 | ||
ORAL | 4 mg in 1 1 | 2024/03/06 | 44523-825 | ||
ORAL | 4 mg in 5 mL | 2022/09/23 | 51991-334 | ||
ORAL | 4 mg in 5 mL | 2024/03/11 | 64950-243 | ||
ORAL | 4 mg in 1 1 | 2022/09/23 | 51991-333 | ||
ORAL | 4 mg in 5 mL | 2023/01/05 | 23594-101 | ||
ORAL | 4 mg in 1 1 | 2024/03/11 | 64950-211 | ||
ORAL | 6 mg in 1 1 | 2024/01/09 | 15370-130 |
EMA Approved Products
Medicine Name | EMA Number | Auth. Holder | Country | Drug Type | Status | Issued | Opinion | Revision |
|---|
No EMA products found
No EMA products found for this drug
HSA Approved Products
Product Name | Manufacturer | Dosage Form | Strength | Approved | Approval No. |
|---|---|---|---|---|---|
TABLET | 4 mg | 1994/12/15 | SIN07964P |
NMPA Approved Products
Product Name | Approval No. | Manufacturer | Dosage Form | Trade Name | Strength | Type | Status | Date | Import |
|---|
No NMPA products found
No NMPA products found for this drug
PPB Approved Products
Product Name | Registration Code | Company | Category | Sale Type | Reg. Date |
|---|---|---|---|---|---|
HK-34395 | yung shin co ltd | Part 1 Poison | Pharmacy only Medicines | 1991/01/08 |
TGA Approved Products
Product Name | ARTG ID | Sponsor | Status | Reg. Date | Ingredient |
|---|
No TGA products found
No TGA products found for this drug