Cisplatin

Generic Name: Cisplatin

Brand Names: Platinol

Drug Type: Small Molecule

Chemical Formula: Cl_₂H_₆N_₂Pt

CAS Number: 15663-27-1

Unique Ingredient Identifier: Q20Q21Q62J

Background: Cisplatin, cisplatinum or cis-diamminedichloroplatinum(II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas and germ cell tumors. It was the first member of its class, which now also includes carboplatin and oxaliplatin.

Indication: For the treatment of metastatic testicular tumors, metastatic ovarian tumors and advanced bladder cancer.

Associated Conditions: Advanced Ovarian Cancer, Ovarian Cancer Metastatic, Advanced Bladder cancer, Advanced Testicular cancer, Metastatic Testicular cancer

Associated Therapies: -

Clinical Trials

Imatinib Mesylate and Chemotherapy in Treating Patients With Extensive-Stage Small Cell Lung Cancer

Phase 1

Completed

Conditions: Lung Cancer

First Posted Date: 2003-01-27

Last Posted Date: 2008-07-24

Lead Sponsor: Memorial Sloan Kettering Cancer Center

Registration Number: NCT00045604

Locations: 🇺🇸
Memorial Sloan-Kettering Cancer Center, New York, New York, United States

High-Dose Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Advanced Cancer

Phase 1

Completed

Conditions: Cancer

Interventions: Biological: filgrastim
Drug: carboplatin
Drug: cisplatin
Drug: cyclophosphamide
Drug: etoposide
Drug: ifosfamide
Drug: mesna
Drug: paclitaxel
Procedure: peripheral blood stem cell transplantation

First Posted Date: 2003-01-27

Last Posted Date: 2015-08-26

Lead Sponsor: City of Hope Medical Center

Target Recruit Count: 33

Registration Number: NCT00002854

Locations: 🇺🇸
City of Hope Comprehensive Cancer Center, Duarte, California, United States

Chemotherapy and Stem Cell Transplantation in Treating Patients With Stage IIIB Breast Cancer

Phase 2

Active, not recruiting

Conditions: Breast Cancer

Interventions: Biological: filgrastim
Drug: cisplatin
Drug: doxorubicin hydrochloride
Drug: cyclophosphamide
Drug: mesna
Drug: melphalan
Drug: paclitaxel
Drug: tamoxifen citrate
Procedure: bone marrow ablation with stem cell support
Procedure: peripheral blood stem cell transplantation
Procedure: conventional surgery

First Posted Date: 2003-01-27

Last Posted Date: 2024-04-02

Lead Sponsor: City of Hope Medical Center

Target Recruit Count: 41

Registration Number: NCT00003042

Locations: 🇺🇸
City of Hope Comprehensive Cancer Center, Duarte, California, United States

Combination Chemotherapy and Peripheral Stem Cell Transplant in Treating Patients With Relapsed Hodgkin's Lymphoma

Phase 3

Conditions: Lymphoma

First Posted Date: 2003-01-27

Last Posted Date: 2013-09-17

Lead Sponsor: German Hodgkin's Lymphoma Study Group

Target Recruit Count: 220

Registration Number: NCT00025636

Locations: 🇧🇪
Ziekenhuis Netwerk Antwerpen Middelheim, Antwerp, Belgium
🇩🇪
Universitaetsklinikum Essen, Essen, Germany
🇩🇪
Klinik Fuer Innere Medizin, Hematology/Oncology, Ernst Moritz Armdt Universitaet, Greifswald, Germany

and more 41 locations

Combination Chemotherapy in Treating Patients With Esophageal Cancer

Phase 3

Conditions: Esophageal Cancer

First Posted Date: 2003-01-27

Last Posted Date: 2013-08-12

Lead Sponsor: Medical Research Council

Target Recruit Count: 1300

Registration Number: NCT00041262

Locations: 🇬🇧
Queen Elizabeth Hospital at University Hospital of Birmingham NHS Trust, Birmingham, England, United Kingdom

Gefitinib and Radiation Therapy With or Without Cisplatin in Treating Patients With Stage III or Stage IV Head and Neck Cancer

Phase 1

Terminated

Conditions: Stage III Squamous Cell Carcinoma of the Larynx
Stage III Squamous Cell Carcinoma of the Lip and Oral Cavity
Stage IV Squamous Cell Carcinoma of the Hypopharynx
Stage IV Squamous Cell Carcinoma of the Larynx
Stage IV Squamous Cell Carcinoma of the Lip and Oral Cavity
Stage III Squamous Cell Carcinoma of the Oropharynx
Stage III Squamous Cell Carcinoma of the Hypopharynx
Stage IV Squamous Cell Carcinoma of the Oropharynx

Interventions: Drug: gefitinib
Radiation: radiation therapy
Drug: cisplatin
Other: laboratory biomarker analysis

First Posted Date: 2003-01-27

Last Posted Date: 2013-01-25

Lead Sponsor: National Cancer Institute (NCI)

Target Recruit Count: 30

Registration Number: NCT00033449

Locations: 🇺🇸
University of Colorado, Denver, Colorado, United States

S0122: Combination Chemotherapy, Radiation Therapy, and Vaccine Therapy in Limited-Stage Small Cell Lung Cancer

Phase 2

Terminated

Conditions: Lung Cancer

Interventions: Biological: monoclonal antibody 11D10 anti-idiotype vaccine
Biological: monoclonal antibody GD2 anti-idiotype vaccine
Drug: cisplatin
Drug: etoposide
Radiation: radiation therapy

First Posted Date: 2003-01-27

Last Posted Date: 2012-06-13

Lead Sponsor: SWOG Cancer Research Network

Target Recruit Count: 9

Registration Number: NCT00045617

Locations: 🇺🇸
CCOP - Columbus, Columbus, Ohio, United States
🇺🇸
Veterans Affairs Outpatient Clinic - Martinez, Martinez, California, United States
🇺🇸
Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, California, United States

and more 97 locations

Radiation Therapy and Cisplatin With or Without Amifostine for Patients With Stage IIIB or IVA Cervical Cancer

Phase 1

Completed

Conditions: Cervical Cancer
Radiation Toxicity

Interventions: Drug: Amifostine trihydrate
Drug: Cisplatin
Radiation: External beam radiation therapy
Radiation: Intracavitary brachytherapy

First Posted Date: 2003-01-27

Last Posted Date: 2015-01-07

Lead Sponsor: Radiation Therapy Oncology Group

Target Recruit Count: 45

Registration Number: NCT00012012

Locations: 🇺🇸
Cancer Treatment Center, Wooster, Ohio, United States
🇺🇸
Akron City Hospital, Akron, Ohio, United States
🇺🇸
Baptist Cancer Institute - Jacksonville, Jacksonville, Florida, United States

and more 14 locations

Chemotherapy Followed by Peripheral Stem Cell Transplantation in Treating Children With Newly Diagnosed Brain Tumor

Phase 2

Withdrawn

Conditions: Retinoblastoma
Brain and Central Nervous System Tumors
Neuroblastoma
Sarcoma

First Posted Date: 2003-01-27

Last Posted Date: 2015-12-03

Lead Sponsor: NYU Langone Health

Registration Number: NCT00003273

Locations: 🇺🇸
Cancer Research Center of Hawaii, Honolulu, Hawaii, United States
🇺🇸
State University of New York Health Sciences Center - Stony Brook, Stony Brook, New York, United States
🇺🇸
Maine Children's Cancer Program, Scarborough, Maine, United States

and more 16 locations

Radiation Therapy and Cisplatin With or Without Epoetin Alfa in Treating Patients With Cervical Cancer and Anemia

Phase 3

Completed

Conditions: Cervical Adenosquamous Carcinoma
Cervical Squamous Cell Carcinoma
Drug Toxicity
Radiation Toxicity
Stage III Cervical Cancer
Cervical Adenocarcinoma
Stage IIB Cervical Cancer
Anemia
Stage IVA Cervical Cancer

Interventions: Radiation: External Beam Radiation Therapy
Drug: Cisplatin
Radiation: Internal Radiation Therapy
Biological: Epoetin Alfa

First Posted Date: 2003-01-27

Last Posted Date: 2017-08-09

Lead Sponsor: Gynecologic Oncology Group

Target Recruit Count: 114

Registration Number: NCT00017004

Locations: 🇺🇸
Gynecologic Oncology Group of Arizona, Phoenix, Arizona, United States

Drug Development Updates

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