Phenoxybenzamine
- Generic Name
- Phenoxybenzamine
- Brand Names
- Dibenzyline
- Drug Type
- Small Molecule
- Chemical Formula
- C18H22ClNO
- CAS Number
- 59-96-1
- Unique Ingredient Identifier
- 0TTZ664R7Z
- Background
An alpha-adrenergic antagonist with long duration of action. It has been used to treat hypertension and as a peripheral vasodilator.
- Indication
For the treatment of phaeochromocytoma (malignant), benign prostatic hypertrophy and malignant essential hypertension.
- Associated Conditions
- Micturition Disorder, Pheochromocytoma, Urinary Retention
- Associated Therapies
- -
The Effect and Safety of Omitting Preoperative Alpha-adrenergic Blockade for Normotensive Pheochromocytoma
Phase 4
Recruiting
- Conditions
- PheochromocytomaAdrenalectomy; StatusAdrenergics Causing Adverse Effects in Therapeutic UseParaganglioma
- Interventions
- First Posted Date
- 2023-01-27
- Last Posted Date
- 2024-04-17
- Lead Sponsor
- Seoul National University Hospital
- Target Recruit Count
- 24
- Registration Number
- NCT05702944
- Locations
- 🇰🇷
Seoul National University Hospital, Seoul, Korea, Republic of
Preoperative Alpha Blockade for Pheochromocytoma
Phase 3
Completed
- Conditions
- ParagangliomaPheochromocytoma
- Interventions
- First Posted Date
- 2017-06-05
- Last Posted Date
- 2023-11-20
- Lead Sponsor
- University of California, Los Angeles
- Target Recruit Count
- 39
- Registration Number
- NCT03176693
- Locations
- 🇺🇸
University of California, Los angeles, Los Angeles, California, United States
Phenoxybenzamine Versus Doxazosin in PCC Patients
- First Posted Date
- 2011-06-23
- Last Posted Date
- 2018-01-31
- Lead Sponsor
- University Medical Center Groningen
- Target Recruit Count
- 134
- Registration Number
- NCT01379898
- Locations
- 🇳🇱
Department of Endocrinology, University Medical Center Groningen, Groningen, Netherlands
Parenteral Phenoxybenzamine During Congenital Heart Disease Surgery
Phase 2
Withdrawn
- Conditions
- Congenital Heart Disease
- Interventions
- Other: Standard surgical approachDrug: Phenoxybenzamine
- First Posted Date
- 2008-10-10
- Last Posted Date
- 2017-05-01
- Lead Sponsor
- Vanderbilt University
- Registration Number
- NCT00770705
- Locations
- 🇺🇸
Vanderbilt Children's Hospital, Nashville, Tennessee, United States
Use of Phenoxybenzamine [PBZ] IV to Assist High Flow Low Pressure Perfusion [HFLPP] on Cardio-pulmonary Bypass
Not Applicable
Terminated
- Conditions
- Congenital Heart SurgeryCardiopulmonary Bypass
- Interventions
- First Posted Date
- 2008-02-22
- Last Posted Date
- 2017-12-19
- Lead Sponsor
- The Cleveland Clinic
- Target Recruit Count
- 87
- Registration Number
- NCT00620945
Intravenous Phenoxybenzamine Use in Pediatric Patients Undergoing Open-Heart Surgery
Phase 2
Completed
- Conditions
- Open-heart SurgeryCardiopulmonary Bypass
- Interventions
- First Posted Date
- 2007-12-10
- Last Posted Date
- 2011-03-01
- Lead Sponsor
- University of Arkansas
- Target Recruit Count
- 785
- Registration Number
- NCT00569855
- Locations
- 🇺🇸
Arkansas Children's Hospital, Little Rock, Arkansas, United States
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