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Phenoxybenzamine

Generic Name
Phenoxybenzamine
Brand Names
Dibenzyline
Drug Type
Small Molecule
Chemical Formula
C18H22ClNO
CAS Number
59-96-1
Unique Ingredient Identifier
0TTZ664R7Z
Background

An alpha-adrenergic antagonist with long duration of action. It has been used to treat hypertension and as a peripheral vasodilator.

Indication

For the treatment of phaeochromocytoma (malignant), benign prostatic hypertrophy and malignant essential hypertension.

Associated Conditions
Micturition Disorder, Pheochromocytoma, Urinary Retention
Clinical Trials
Related News

The Effect and Safety of Omitting Preoperative Alpha-adrenergic Blockade for Normotensive Pheochromocytoma

Phase 4
Recruiting
Conditions
Pheochromocytoma
Adrenalectomy; Status
Adrenergics Causing Adverse Effects in Therapeutic Use
Paraganglioma
Interventions
First Posted Date
2023-01-27
Last Posted Date
2024-04-17
Lead Sponsor
Seoul National University Hospital
Target Recruit Count
24
Registration Number
NCT05702944
Locations
🇰🇷

Seoul National University Hospital, Seoul, Korea, Republic of

Preoperative Alpha Blockade for Pheochromocytoma

Phase 3
Completed
Conditions
Paraganglioma
Pheochromocytoma
Interventions
First Posted Date
2017-06-05
Last Posted Date
2023-11-20
Lead Sponsor
University of California, Los Angeles
Target Recruit Count
39
Registration Number
NCT03176693
Locations
🇺🇸

University of California, Los angeles, Los Angeles, California, United States

Phenoxybenzamine Versus Doxazosin in PCC Patients

Phase 4
Completed
Conditions
Pheochromocytoma
Interventions
First Posted Date
2011-06-23
Last Posted Date
2018-01-31
Lead Sponsor
University Medical Center Groningen
Target Recruit Count
134
Registration Number
NCT01379898
Locations
🇳🇱

Department of Endocrinology, University Medical Center Groningen, Groningen, Netherlands

Parenteral Phenoxybenzamine During Congenital Heart Disease Surgery

Phase 2
Withdrawn
Conditions
Congenital Heart Disease
Interventions
Other: Standard surgical approach
First Posted Date
2008-10-10
Last Posted Date
2017-05-01
Lead Sponsor
Vanderbilt University
Registration Number
NCT00770705
Locations
🇺🇸

Vanderbilt Children's Hospital, Nashville, Tennessee, United States

Use of Phenoxybenzamine [PBZ] IV to Assist High Flow Low Pressure Perfusion [HFLPP] on Cardio-pulmonary Bypass

Not Applicable
Terminated
Conditions
Congenital Heart Surgery
Cardiopulmonary Bypass
Interventions
First Posted Date
2008-02-22
Last Posted Date
2017-12-19
Lead Sponsor
The Cleveland Clinic
Target Recruit Count
87
Registration Number
NCT00620945

Intravenous Phenoxybenzamine Use in Pediatric Patients Undergoing Open-Heart Surgery

Phase 2
Completed
Conditions
Open-heart Surgery
Cardiopulmonary Bypass
Interventions
First Posted Date
2007-12-10
Last Posted Date
2011-03-01
Lead Sponsor
University of Arkansas
Target Recruit Count
785
Registration Number
NCT00569855
Locations
🇺🇸

Arkansas Children's Hospital, Little Rock, Arkansas, United States

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