Mexiletine

Generic Name
Mexiletine
Brand Names
Namuscla
Drug Type
Small Molecule
Chemical Formula
C11H17NO
CAS Number
31828-71-4
Unique Ingredient Identifier
1U511HHV4Z
Background

Antiarrhythmic agent pharmacologically similar to lidocaine. It may have some anticonvulsant properties.

Indication

For the treatment of ventricular tachycardia and symptomatic premature ventricular beats, and prevention of ventricular fibrillation.

Associated Conditions
Ventricular Arrhythmia, Ventricular Tachycardia, Sustained
Associated Therapies
-
Clinical Trials
Related News

Combined N-of-1 Trials Mexiletine vs Placebo in Patients With Non-Dystrophic Myotonia (NDM)

Phase 2
Completed
Conditions
Non Dystrophic Myotonia
Interventions
Drug: Mexiletine
Drug: Placebo
First Posted Date
2014-01-27
Last Posted Date
2016-01-26
Lead Sponsor
Radboud University Medical Center
Target Recruit Count
30
Registration Number
NCT02045667
Locations
🇳🇱

Departments of Neurology, Radboud University Nijmegen Medical Centre, the Netherlands, Nijmegen, Gelderland, Netherlands

Mexiletine in Sporadic Amyotrophic Lateral Sclerosis (SALS)

First Posted Date
2013-05-08
Last Posted Date
2021-09-29
Lead Sponsor
University of Washington
Target Recruit Count
75
Registration Number
NCT01849770
Locations
🇺🇸

University of Massachusetts (Worcester) Memorial Medical Center, Worcester, Massachusetts, United States

🇺🇸

University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States

🇺🇸

University of Iowa, Iowa City, Iowa, United States

and more 7 locations

Mexiletine for the Treatment of Muscle Cramps in ALS

First Posted Date
2013-03-14
Last Posted Date
2017-08-28
Lead Sponsor
Bjorn Oskarsson, MD
Target Recruit Count
23
Registration Number
NCT01811355
Locations
🇺🇸

UCD Telehealth Network - Lake Almanor Clinic, Chester, California, United States

🇺🇸

UCSD Department of Neurosciences ALS Clinical Trials (ACT) Program, La Jolla, California, United States

🇺🇸

UCD Telehealth Network, Multiple Locations, California, United States

and more 3 locations

Effects of Mexiletine on Colonic Transit in a Patient With Irritable Bowel Syndrome - Constipation (IBS-C)

Phase 1
Completed
Conditions
IBS
Interventions
Drug: Mexiletine
First Posted Date
2012-10-30
Last Posted Date
2013-10-01
Lead Sponsor
Mayo Clinic
Target Recruit Count
1
Registration Number
NCT01717404

Clinical Efficacy Trial of Mexiletine for Myotonic Dystrophy Type 1

Phase 2
Completed
Conditions
Myotonic Dystrophy
Interventions
Drug: Placebo
Drug: Mexiletine
First Posted Date
2011-08-01
Last Posted Date
2018-06-19
Lead Sponsor
University of Rochester
Target Recruit Count
42
Registration Number
NCT01406873
Locations
🇺🇸

University of Rochester Medical Center, Department of Neurology, Rochester, New York, United States

Effectiveness of Mexiletine for Treating People With Non-Dystrophic Myotonia

First Posted Date
2009-01-29
Last Posted Date
2013-08-23
Lead Sponsor
Richard Barohn, MD
Target Recruit Count
59
Registration Number
NCT00832000
Locations
🇺🇸

Brigham & Women's Hospital, Boston, Massachusetts, United States

🇮🇹

University of Milan, Milan, Italy

🇺🇸

University of Texas Southwestern Medical Center, Dallas, Texas, United States

and more 4 locations

Phase III Randomized, Double-Blind, Placebo-Controlled Study of Mexiletine for Painful Diabetic Neuropathy

Phase 3
Completed
Conditions
Pain
Diabetic Neuropathies
Paresthesia
First Posted Date
2000-02-25
Last Posted Date
2005-06-24
Lead Sponsor
National Center for Research Resources (NCRR)
Target Recruit Count
40
Registration Number
NCT00004647

Mexiletine for the Treatment of Focal Dystonia

Phase 2
Completed
Conditions
Blepharospasm
Dystonia
Spasm
First Posted Date
1999-11-04
Last Posted Date
2008-03-04
Lead Sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
Target Recruit Count
24
Registration Number
NCT00001784
Locations
🇺🇸

National Institute of Neurological Disorders and Stroke (NINDS), Bethesda, Maryland, United States

Cardiac Arrest in Seattle: Conventional Versus Amiodarone Drug Evaluation (CASCADE)

First Posted Date
1999-10-28
Last Posted Date
2013-07-29
Lead Sponsor
University of Washington
Registration Number
NCT00000464

Electrophysiologic Study Versus Electrocardiographic Monitoring (ESVEM)

First Posted Date
1999-10-28
Last Posted Date
2016-01-21
Lead Sponsor
University of Utah
Registration Number
NCT00000518
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