Armodafinil
- Generic Name
- Armodafinil
- Brand Names
- Nuvigil
- Drug Type
- Small Molecule
- Chemical Formula
- C15H15NO2S
- CAS Number
- 112111-43-0
- Unique Ingredient Identifier
- V63XWA605I
- Background
Armodafinil is the enantiopure of the wakefulness-promoting agent modafinil (Provigil), and is indicated to improve wakefulness in adult patients with excessive sleepiness associated with obstructive sleep apnea (OSA), narcolepsy, or shift work disorder (SWD). Research has shown that armodafinil significantly improves driving simulator performance in patient...
- Indication
用于改善与阻塞性睡眠呼吸暂停（OSA）、发作性睡病或轮班工作障碍（SWD）相关的过度嗜睡的成年患者的清醒度。亦可用于治疗注意缺陷多动障碍、慢性疲劳综合征和重度抑郁症。
- Associated Conditions
- Narcolepsy, Shift-work related sleep disturbance, Somnolence
- Associated Therapies
- -
Impact of Armodafinil on Neurocognition and Cognitive Fatigue in Multiple Sclerosis (MS)
- First Posted Date
- 2009-09-22
- Last Posted Date
- 2013-10-14
- Lead Sponsor
- University of Missouri, Kansas City
- Target Recruit Count
- 33
- Registration Number
- NCT00981084
- Locations
- 🇺🇸
University of Kansas Medical Center, Kansas City, Kansas, United States
Study to Evaluate the Efficacy and Safety of Armodafinil as Treatment for Patients With Excessive Sleepiness Associated With Mild or Moderate Closed Traumatic Brain Injury
- First Posted Date
- 2009-05-06
- Last Posted Date
- 2021-12-17
- Lead Sponsor
- Cephalon, Inc.
- Target Recruit Count
- 117
- Registration Number
- NCT00893789
- Locations
- 🇺🇸
Teva Investigational Site 61, Germantown, Tennessee, United States
🇺🇸Teva Investigational Site 26, Atlanta, Georgia, United States
🇺🇸Teva Investigational Site 56, Lincoln, Nebraska, United States
Study to Evaluate the Efficacy and Safety of Armodafinil as Adjunctive Therapy in Adults With Schizophrenia
- First Posted Date
- 2008-10-15
- Last Posted Date
- 2012-07-27
- Lead Sponsor
- Cephalon
- Target Recruit Count
- 287
- Registration Number
- NCT00772005
- Locations
- 🇺🇸
Synergy Clinical Research Center, Escondido, California, United States
🇺🇸Collaborative NeuroScience, Garden Grove, California, United States
🇺🇸Excell Research, Oceanside, California, United States
A Randomized Placebo-Controlled Trial of Armodafinil (Nuvigil) for Fatigue in Patients With Malignant Gliomas
- First Posted Date
- 2008-10-06
- Last Posted Date
- 2016-07-28
- Lead Sponsor
- Eudocia Quant Lee, MD
- Target Recruit Count
- 81
- Registration Number
- NCT00766467
- Locations
- 🇺🇸
Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, United States
🇺🇸Dana-Farber Cancer Institute, Boston, Massachusetts, United States
🇺🇸UCSD San Diego, La Jolla, California, United States
Study of the Effect of Armodafinil Treatment in Healthy Subjects With Excessive Sleepiness Associated With Jet Lag Disorder
- First Posted Date
- 2008-09-25
- Last Posted Date
- 2013-07-19
- Lead Sponsor
- Cephalon
- Target Recruit Count
- 427
- Registration Number
- NCT00758498
- Locations
- 🇺🇸
Clinilabs, Inc., New York, New York, United States
🇺🇸Community Research, Crestview, Kentucky, United States
🇺🇸Neurotrials Research, Inc., Atlanta, Georgia, United States
Effectiveness of Armodafinil for Treating Fatigue in Adults With HIV/AIDS
- First Posted Date
- 2008-08-18
- Last Posted Date
- 2014-06-12
- Lead Sponsor
- New York State Psychiatric Institute
- Target Recruit Count
- 70
- Registration Number
- NCT00737204
- Locations
- 🇺🇸
New York State Psychiatric Institute, New York, New York, United States
Study to Evaluate Armodafinil Treatment in Improving Prefrontal Cortical Activation and Working Memory Performance
- First Posted Date
- 2008-07-09
- Last Posted Date
- 2013-07-19
- Lead Sponsor
- Cephalon
- Target Recruit Count
- 40
- Registration Number
- NCT00711516
- Locations
- 🇺🇸
VA San Diego Healthcare System, San Diego, California, United States
🇺🇸Duke University Medical Center, Durham, North Carolina, United States
🇺🇸Pacific Research, San Diego, California, United States
An Eight Week, Double-Blind Efficacy Study of Armodafinil Augmentation to Alleviate Fibromyalgia Fatigue
- First Posted Date
- 2008-05-15
- Last Posted Date
- 2014-12-18
- Target Recruit Count
- 55
- Registration Number
- NCT00678691
- Locations
- 🇺🇸
SUNY Upstate Medical University, Syracuse, New York, United States
PET Study Examining the Dopaminergic Activity of Armodafinil in Adults
- First Posted Date
- 2008-01-14
- Last Posted Date
- 2013-11-13
- Lead Sponsor
- Massachusetts General Hospital
- Target Recruit Count
- 12
- Registration Number
- NCT00592943
- Locations
- 🇺🇸
Massachusetts General Hospital, Cambridge, Massachusetts, United States
Use of Armodafinil for Fatigue in Sarcoidosis
- First Posted Date
- 2007-11-08
- Last Posted Date
- 2015-05-27
- Lead Sponsor
- University of Cincinnati
- Target Recruit Count
- 20
- Registration Number
- NCT00555347
- Locations
- 🇺🇸
University of Cincinnati, Cincinnati, Ohio, United States
Drug Development Updates
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