DeepMed Research

Bisacodyl

Generic Name: Bisacodyl

Brand Names: Alophen Reformulated Jan 2008, Bi-peglyte, Bisac-evac, Carters Little Pills, Dulcolax, Fleet Mineral Oil, Gavilyte-H and Bisacodyl

Drug Type: Small Molecule

Chemical Formula: C_₂₂H_₁₉NO_₄

CAS Number: 603-50-9

Unique Ingredient Identifier: 10X0709Y6I

Background: Bisacodyl, a diphenylmethane derivative, is a commonly used over the counter stimulant laxative for occasional constipation. Both bisacodyl and picosulfate are metabolized to the same active metabolite bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM).

Bisacodyl was patented on 25 September 1956 but has been used as a laxative since 1952.

Indication: Bisacodyl is indicated to relieve occasional constipation and irregularity.

Associated Conditions: Bowel movement irregularity, Constipation, Occasional Constipation

Associated Therapies: Bowel preparation therapy

Clinical Trials

Low-dose Laxative Improves Performance and Feasibility of Computed Tomography Colonography (CTC)

Phase 4

Completed

Conditions: Gastrointestinal Complication

Interventions: Drug: Bisacodyl & PEG-CS
Drug: Iopamidol

First Posted Date: 2014-01-20

Last Posted Date: 2014-01-20

Lead Sponsor: Azienda Policlinico Umberto I

Target Recruit Count: 52

Registration Number: NCT02040285

Locations: 🇮🇹
Policlinico Umberto I, Roma, Italy

12-Week Study of Plecanatide for CIC (The CIC3 Study)

Phase 3

Completed

Conditions: Chronic Idiopathic Constipation

Interventions: Drug: Placebo
Drug: Bisacodyl
Drug: Plecanatide

First Posted Date: 2013-11-13

Last Posted Date: 2019-12-26

Lead Sponsor: Bausch Health Americas, Inc.

Target Recruit Count: 1394

Registration Number: NCT01982240

Locations: 🇨🇦
Synergy Research Site, St-Romuald, Quebec, Canada

Effect of Octreotide on the Colonic Motility in Pediatric Patients

Phase 4

Completed

Conditions: Colonic Motility Index
Constipation

Interventions: Drug: Octreotide
Drug: Bisacodyl

First Posted Date: 2013-08-07

Last Posted Date: 2015-12-21

Lead Sponsor: Indiana University

Target Recruit Count: 13

Registration Number: NCT01917773

Locations: 🇺🇸
Motility Laboratory, Division of Pediatric Gastroenterology, Hepatology and Nutrition at the James Whitcomb Riley Hospital for Children,, Indianapolis, Indiana, United States

Efficacy of 2-Liter Mixed Preparation With Bisacodyl Plus Polyethylene Glycol and 4-Liter Polyethylene Glycol for Colon Cleansing in Patients With Prior History of Colorectal Resection

Phase 4

Completed

Conditions: Intestinal Cancer

Interventions: Drug: Polyethylene glycol
Drug: Bisacodyl

First Posted Date: 2013-06-26

Last Posted Date: 2014-06-17

Lead Sponsor: Ospedale Santa Maria delle Croci

Target Recruit Count: 116

Registration Number: NCT01887158

Locations: 🇮🇹
Ospedale S.Maria delle Croci, Ravenna, RA, Italy
🇮🇹
Alessandro Mussetto, Ravenna, RA, Italy

Safety and Tolerability of Oral Polyethylene Glycol (PEG 3350) Solution in Participants With Constipation (MK-8114-003)

Phase 2

Completed

Conditions: Constipation

Interventions: Drug: Placebo
Drug: Polyethylene Glycol (PEG 3350)
Drug: Bisacodyl laxative tablets (rescue medication)

First Posted Date: 2013-06-24

Last Posted Date: 2015-03-11

Lead Sponsor: Bayer

Target Recruit Count: 65

Registration Number: NCT01885104

Study About Effect of Preoperative Bowel Preparation Versus no Bowel Preparation Before Spinal Surgery

Phase 4

Completed

Conditions: Constipation
Ileus
Surgery

Interventions: Drug: Bisacodyl
Drug: Docusate natrium and sorbitol

First Posted Date: 2013-06-18

Last Posted Date: 2013-06-18

Lead Sponsor: Oslo University Hospital

Target Recruit Count: 45

Registration Number: NCT01879605

Locations: 🇳🇴
Oslo Universitetssykehus, Oslo, Norway

Multidisciplinary Approach Versus Conventional Approach in Colonic Preparation of Hospitalized Patients

Phase 4

Conditions: Bowel Preparation for Colonoscopy

Interventions: Behavioral: Education
Other: Fiber free diet
Dietary Supplement: Adjuvants
Drug: Polyethylene glycol (PEG)
Drug: Bisacodyl

First Posted Date: 2013-05-15

Last Posted Date: 2013-05-15

Lead Sponsor: Corporacion Parc Tauli

Target Recruit Count: 162

Registration Number: NCT01853709

Locations: 🇪🇸
Hospital de Sabadell, Sabadell, Barcelona, Spain

Bowel Cleansing for Colonoscopy: Comparison Between a Same Day Low-Volume Preparation and a Conventional 4L Split One

Phase 3

Completed

Conditions: Colonoscopy

Interventions: Drug: PEG 4 litres split
Drug: Bisacodyl plus PEG-CS

First Posted Date: 2012-09-14

Last Posted Date: 2012-09-19

Lead Sponsor: European Institute of Oncology

Target Recruit Count: 164

Registration Number: NCT01685853

Locations: 🇮🇹
European Institute of Oncology, Milan, Italy

Improving Bowel Preparation for the Colon Capsule

Phase 3

Completed

Conditions: Quality of Bowel Preparation for the Colon Capsule
Colon Capsule Completion Rates
Colon Capsule Polyp Detection

Interventions: Drug: PEG
Drug: Prucalopride
Drug: Picosalax
Procedure: Colon capsule
Drug: Bisacodyl
Procedure: Colonoscopy

First Posted Date: 2012-08-01

Last Posted Date: 2015-12-03

Lead Sponsor: Queen's University

Target Recruit Count: 20

Registration Number: NCT01655095

Locations: 🇨🇦
Hotel Dieu Hospital, Kingston, Ontario, Canada

Colonoscopy Preparation Optimization for INpatients- COIN Study

Phase 4

Conditions: Endoscopy
Bowel Preparation Solutions

Interventions: Drug: Bisacodyl 10mg
Drug: Polyethelene Glycol
Drug: Picosulfate sodium

First Posted Date: 2012-06-25

Last Posted Date: 2013-01-30

Lead Sponsor: St. Joseph's Healthcare Hamilton

Target Recruit Count: 126

Registration Number: NCT01627171

Locations: 🇨🇦
St Joseph Hospital, Hamilton, Ontario, Canada

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