Trimer 4571 vaccine
- Generic Name
- Trimer 4571 vaccine
Clinical Trial to Evaluate the Safety, Tolerability, and Immunogenicity of 16055 NFL Delta Gly4 Env Protein Trimer and Trimer 4571 Combined With 3M-052-AF + Alum Adjuvant and Ad4-Env145NFL Viral Particles as Heterologous Prime-boost Regimens in Adult Participants Without HIV.
Phase 1
Active, not recruiting
- Conditions
- HIV
- Interventions
- Biological: 16055 NFL delta Gly4 trimerBiological: Ad4-Env145NFL, 5 x 108 viral particles (vp)
- First Posted Date
- 2024-03-27
- Last Posted Date
- 2024-11-05
- Target Recruit Count
- 45
- Registration Number
- NCT06332339
- Locations
- ๐บ๐ธ
Alabama CRS, Birmingham, Alabama, United States
๐บ๐ธBrigham and Women's Hospital Vaccine CRS (BWH VCRS), Boston, Massachusetts, United States
๐บ๐ธThe Hope Clinic of the Emory Vaccine Center CRS Site# 31440, Decatur, Georgia, United States
Clinical Trial to Evaluate the Safety and Immunogenicity of Synthetic DNAs Encoding NP-GT8 and IL-12, With or Without a TLR-agonist-Adjuvanted HIV Env Trimer 4571 Boost, in Adults Without HIV
Phase 1
Active, not recruiting
- Conditions
- HIV Infections
- Interventions
- Biological: sD-NP-GT8 DNABiological: 3M-052-AF
- First Posted Date
- 2023-03-23
- Last Posted Date
- 2024-12-17
- Target Recruit Count
- 46
- Registration Number
- NCT05781542
- Locations
- ๐ฟ๐ฆ
Durban Adult HIV CRS, Durban, KwaZulu-Natal, South Africa
๐บ๐ธBridge HIV CRS, San Francisco, California, United States
๐ฟ๐ฆSoweto HVTN CRS, Johannesburg, Gauteng, South Africa
Evaluating the Safety and Immunogenicity of HIV-1 BG505 SOSIP.664 gp140 With TLR Agonist and/or Alum Adjuvants in Healthy, HIV-uninfected Adults
Phase 1
Completed
- Conditions
- HIV Infections
- Interventions
- Biological: BG505 SOSIP.664 gp140Biological: PlaceboBiological: GLA-LSQBiological: 3M-052-AF
- First Posted Date
- 2019-11-26
- Last Posted Date
- 2025-03-06
- Target Recruit Count
- 127
- Registration Number
- NCT04177355
- Locations
- ๐บ๐ธ
Penn Prevention CRS, Philadelphia, Pennsylvania, United States
๐บ๐ธThe Ponce de Leon Center CRS, Atlanta, Georgia, United States
๐บ๐ธThe Hope Clinic of the Emory Vaccine Center CRS, Decatur, Georgia, United States
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