格列齐特 (Diamicron)

概览

Gliclazide is a sulfonylurea used to treat hyperglycemia in patients with type 2 diabetes mellitus.

作用机制

Gliclazide binds to the β cell sulfonyl urea receptor (SUR1). This binding subsequently blocks the ATP sensitive potassium channels. The binding results in closure of the channels and leads to a resulting decrease in potassium efflux leads to depolarization of the β cells. This opens voltage-dependent calcium channels in the β cell resulting in calmodulin activation, which in turn leads to exocytosis of insulin containing secretorty granules.

适应症

For the treatment of NIDDM in conjunction with diet and exercise.

• Type 2 Diabetes Mellitus