Ropivacaine

Generic Name: Ropivacaine

Brand Names: Naropin

Drug Type: Small Molecule

Chemical Formula: C_₁₇H_₂₆N_₂O

CAS Number: 84057-95-4

Unique Ingredient Identifier: 7IO5LYA57N

Background: Ropivacaine is an aminoamide local anesthetic drug marketed by AstraZeneca under the trade name Naropin. It exists as a racemate of its S- and R-enantiomers, although the marketed form is supplied only as the purified S-enantiomer.

Indication: Ropivacaine is indicated in adult patients for the induction of regional or local anesthesia for surgery or acute pain management.

Associated Conditions: Acute Pain, Postoperative pain

Associated Therapies: Surgical anesthesia therapy

Clinical Trials

Efficacy of Compound Betamethasone Injection Combined With Ropivacaine in Ultrasound-guided Thoracic Paravertebral Nerve Block for Chronic Post-thoracotomy Pain

Phase 4

Conditions: Chronic Pain

Interventions: Drug: Diprospan
Drug: Ropivacaine

First Posted Date: 2022-01-03

Last Posted Date: 2022-03-02

Lead Sponsor: Affiliated Hospital of Nantong University

Target Recruit Count: 100

Registration Number: NCT05175001

Locations: 🇨🇳
Affiliated Hospital of Nantong University, Nantong, Jiangsu, China

Phase 2/3 Study of TLC590 for Postsurgical Pain Management

Phase 2

Not yet recruiting

Conditions: Postsurgical Pain Management

Interventions: Drug: Normal saline
Drug: TLC590
Drug: Bupivacain
Drug: Ropivacaine

First Posted Date: 2021-12-17

Last Posted Date: 2024-04-11

Lead Sponsor: Taiwan Liposome Company

Target Recruit Count: 415

Registration Number: NCT05161637

Propofol EC50 for Inducing Loss of Consciousness in General Combined Epidural Anesthesia

Not Applicable

Completed

Conditions: Gastric Cancer

Interventions: Drug: 5-8ml 0.375% ropivacaine
Other: 5-8ml normal saline

First Posted Date: 2021-11-18

Last Posted Date: 2025-01-09

Lead Sponsor: Wang Jiangling

Target Recruit Count: 60

Registration Number: NCT05124704

Locations: 🇨🇳
Cancer Hospital of the University of Chinese Academy of Sciences, Hangzhou, Zhejiang, China

Effect of Transversus Abdominis Plane Block With Compound Lidocaine and Esketamine on Pain After Surgery

Not Applicable

Conditions: Postoperative Pain

Interventions: Drug: Compound lidocaine
Drug: Normal saline
Drug: Ropivacaine
Drug: Esketamine

First Posted Date: 2021-11-16

Last Posted Date: 2021-11-16

Lead Sponsor: Tianjin Medical University General Hospital

Target Recruit Count: 160

Registration Number: NCT05122338

Efficacy of Dexmedetomidine on Postoperative Analgesia

Not Applicable

Completed

Conditions: Postoperative Pain

Interventions: Drug: Ropivacaine plus dexmedetomidine
Drug: Ropivacaine

First Posted Date: 2021-11-05

Last Posted Date: 2021-11-05

Lead Sponsor: Universidad Autónoma de Tamaulipas

Target Recruit Count: 28

Registration Number: NCT05110339

Locations: 🇲🇽
Jose Camilo Muñoz Chaves, Matamoros, Tamaulipas, Mexico

Transmucular Quadratus Lumborum Block: Potential Quadriceps Muscle Weakness

Phase 4

Completed

Conditions: Neuromuscular Blockade

Interventions: Drug: Ropivacaine
Other: Quadriceps muscle strength
Other: Timed Up and Go
Other: Single-leg 6 meter timed hop test
Other: Temperature discrimination
Other: Pinprick test
Diagnostic Test: Blood samples
Diagnostic Test: Non-invasive blood pressure measurement

First Posted Date: 2021-08-26

Last Posted Date: 2021-12-21

Lead Sponsor: Zealand University Hospital

Target Recruit Count: 20

Registration Number: NCT05023343

Locations: 🇩🇰
Department of Anaesthesiology and Intensive Care Medicine, Zealand University Hospital, Roskilde, Roskilde, Zealand Region, Denmark

Ultrasound-guided Selective Supraclavicular Nerve Block for Postoperative Pain Control in Pediatric Patients.

Not Applicable

Completed

Conditions: Cancer Pediatric

Interventions: Other: Control (without intervention)
Drug: Ropivacaine

First Posted Date: 2021-08-23

Last Posted Date: 2023-02-28

Lead Sponsor: Seoul National University Hospital

Target Recruit Count: 50

Registration Number: NCT05015907

Locations: 🇰🇷
Jin-Tae Kim, Seoul, Korea, Republic of

Effect of Ultrasound-guided Transversus Abdominis Plane Block After Laparoscopic Bariatric Surgery

Phase 2

Conditions: Laparoscopic Bariatric Surgery
Nausea and Vomiting

Interventions: Drug: Ropivacaine

First Posted Date: 2021-08-23

Last Posted Date: 2021-08-23

Lead Sponsor: Tianjin Medical University General Hospital

Target Recruit Count: 120

Registration Number: NCT05016180

Locations: 🇨🇳
Tianjin Medical University General Hospital, Tianjin, Tianjin, China
🇨🇳
Zhen Jia, Tianjin, Tianjin, China

Effect of Transversus Abdominis Plane Block With Compound Lidocaine on Pain After Gynecological Surgery

Not Applicable

Completed

Conditions: Postoperative Pain

Interventions: Drug: Normal saline
Drug: Ropivacaine
Drug: Compound lidocaine at low concentration
Drug: Compound lidocaine at high concentration

First Posted Date: 2021-06-24

Last Posted Date: 2022-02-23

Lead Sponsor: Tianjin Medical University General Hospital

Target Recruit Count: 164

Registration Number: NCT04938882

Locations: 🇨🇳
Tianjin Medical University General Hospital, Tianjin, China

Postoperative Pain Relief With Transversus Thoracis Muscle Plane Block After Cardiac Surgery

Phase 4

Active, not recruiting

Conditions: Pain, Postoperative
Anesthesia, Local
Coronary Artery Disease
Heart Valve Diseases

Interventions: Drug: Placebo
Drug: Ropivacaine

First Posted Date: 2021-06-07

Last Posted Date: 2024-04-25

Lead Sponsor: Turku University Hospital

Target Recruit Count: 120

Registration Number: NCT04916418

Locations: 🇫🇮
Perioperative Services, Intensive Care and Pain Therapy, Turku University Hospital and University of Turku, Turku, Finland

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