Clobetasol propionate
- Generic Name
- Clobetasol propionate
- Brand Names
- Clobex, Clodan, Dermovate, Impeklo, Impoyz, Olux, Temovate, Tovet
- Drug Type
- Small Molecule
- Chemical Formula
- C25H32ClFO5
- CAS Number
- 25122-46-7
- Unique Ingredient Identifier
- 779619577M
- Background
Clobetasol propionate is a prednisolone derivative with higher specificity for glucocorticoid receptors than mineralocorticoid receptors. It has demonstrated superior activity compared to fluocinonide and was first described in the literature in 1974.
Clobetasol Propionate was granted FDA approval on 27 December 1985.
- Indication
Clobetasol propionate is indicated to treat moderate to severe plaque psoriasis as well as inflammatory and pruritic manifestations of corticosteroid responsive dermatoses.
- Associated Conditions
- Alopecia, Severe Plaque psoriasis, Corticosteroid responsive, Inflammatory Dermatosis, Corticosteroid responsive, pruritic Dermatosis, Moderate Plaque psoriasis, Moderate Scalp Psoriasis, Severe Scalp Psoriasis
- Associated Therapies
- -
A Study Assessing GW870086's Potential to Cause Skin Thinning
- Conditions
- Interventions
- First Posted Date
- 2011-06-27
- Last Posted Date
- 2017-07-21
- Lead Sponsor
- GlaxoSmithKline
- Target Recruit Count
- 20
- Registration Number
- NCT01381445
- Locations
- 🇩🇪
GSK Investigational Site, Berlin, Germany
Ethanol-Free Clobetasol Propionate Foam 0.05% (Olux-E Foam) vs Vehicle Foam in the Treatment of Chronic Hand Dermatitis.
- Conditions
- Interventions
- First Posted Date
- 2011-03-25
- Last Posted Date
- 2018-06-20
- Lead Sponsor
- Stiefel, a GSK Company
- Target Recruit Count
- 125
- Registration Number
- NCT01323673
- Locations
- 🇺🇸
GSK Investigational Site, Austin, Texas, United States
Progesterone vs Clobetasol Propionate in Vulvar Lichen Sclerosus
- Conditions
- Interventions
- First Posted Date
- 2010-05-19
- Last Posted Date
- 2022-04-01
- Lead Sponsor
- Insel Gruppe AG, University Hospital Bern
- Target Recruit Count
- 37
- Registration Number
- NCT01126255
- Locations
- 🇨🇭
Dep. of Obstetrics and Gynecology, Bern University Hospital, Bern, Switzerland
Study to Evaluate Safety, Efficacy and Tolerability of Clobetasol Propionate for Chronic Hand Dermatitis
- First Posted Date
- 2009-01-26
- Last Posted Date
- 2012-10-03
- Lead Sponsor
- Stiefel, a GSK Company
- Target Recruit Count
- 30
- Registration Number
- NCT00828464
- Locations
- 🇺🇸
Physicians Skin Care, Louisville, Kentucky, United States
Efficacy of Glycerol, Two Topical Steroids, and a Topical Immune Modulator Against Skin Irritation
- Conditions
- First Posted Date
- 2008-10-24
- Last Posted Date
- 2008-10-24
- Lead Sponsor
- Odense University Hospital
- Target Recruit Count
- 36
- Registration Number
- NCT00779792
- Locations
- 🇩🇰
Department of Dermatology, Odense University Hospital, Odense, Denmark
Effectiveness and Safety of Topical Halobetasol Propionate in the Treatment of Patients With Psoriasis
- First Posted Date
- 2008-07-15
- Last Posted Date
- 2010-09-02
- Lead Sponsor
- Azidus Brasil
- Target Recruit Count
- 140
- Registration Number
- NCT00715975
- Locations
- 🇧🇷
Lal Clinica, Valinhos, Sao Paulo, Brazil
Mechanistically-based Optimization of UV Radiation Therapy in Psoriasis
- First Posted Date
- 2007-05-07
- Last Posted Date
- 2016-10-05
- Lead Sponsor
- VA Office of Research and Development
- Target Recruit Count
- 9
- Registration Number
- NCT00470392
- Locations
- 🇺🇸
VA Medical Center, Cleveland, Cleveland, Ohio, United States
🇺🇸University Hospital Case Medical Center, Cleveland, Ohio, United States
Drug Development Updates
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