Clobetasol propionate
- Generic Name
- Clobetasol propionate
- Brand Names
- Clobex, Clodan, Dermovate, Impeklo, Impoyz, Olux, Temovate, Tovet
- Drug Type
- Small Molecule
- Chemical Formula
- C25H32ClFO5
- CAS Number
- 25122-46-7
- Unique Ingredient Identifier
- 779619577M
- Background
Clobetasol propionate is a prednisolone derivative with higher specificity for glucocorticoid receptors than mineralocorticoid receptors. It has demonstrated superior activity compared to fluocinonide and was first described in the literature in 1974.
Clobetasol Propionate was granted FDA approval on 27 December 1985.
- Indication
Clobetasol propionate is indicated to treat moderate to severe plaque psoriasis as well as inflammatory and pruritic manifestations of corticosteroid responsive dermatoses.
- Associated Conditions
- Alopecia, Severe Plaque psoriasis, Corticosteroid responsive, Inflammatory Dermatosis, Corticosteroid responsive, pruritic Dermatosis, Moderate Plaque psoriasis, Moderate Scalp Psoriasis, Severe Scalp Psoriasis
A Study Assessing GW870086's Potential to Cause Skin Thinning
- Conditions
- Dermatitis, Atopic
- Interventions
- First Posted Date
- 2011-06-27
- Last Posted Date
- 2017-07-21
- Lead Sponsor
- GlaxoSmithKline
- Target Recruit Count
- 20
- Registration Number
- NCT01381445
- Locations
- 🇩🇪
GSK Investigational Site, Berlin, Germany
Ethanol-Free Clobetasol Propionate Foam 0.05% (Olux-E Foam) vs Vehicle Foam in the Treatment of Chronic Hand Dermatitis.
- Conditions
- Dermatitis, Chronic
- Interventions
- Drug: Vehicle / Placebo
- First Posted Date
- 2011-03-25
- Last Posted Date
- 2018-06-20
- Lead Sponsor
- Stiefel, a GSK Company
- Target Recruit Count
- 125
- Registration Number
- NCT01323673
- Locations
- 🇺🇸
GSK Investigational Site, Austin, Texas, United States
Treatment of Female Genital Erosive Lichen Planus(GELP) With Hexaminolevulinate PDT
- Conditions
- Genital Lichen Planus
- Interventions
- First Posted Date
- 2011-01-25
- Last Posted Date
- 2021-03-17
- Lead Sponsor
- Oslo University Hospital
- Target Recruit Count
- 40
- Registration Number
- NCT01282515
- Locations
- 🇳🇴
Rikshospitalet, OsloUniversity hospital, Oslo, Norway
Study to Evaluate Vectical in Combination With Clobex Spray to Treatment Plaque Psoriasis
- First Posted Date
- 2010-09-21
- Last Posted Date
- 2010-09-21
- Lead Sponsor
- Emer, Jason, M.D.
- Target Recruit Count
- 12
- Registration Number
- NCT01205880
- Locations
- 🇺🇸
Mount Sinai School of Medicine, New York, New York, United States
Progesterone vs Clobetasol Propionate in Vulvar Lichen Sclerosus
- Conditions
- Vulvar Lichen Sclerosus
- Interventions
- First Posted Date
- 2010-05-19
- Last Posted Date
- 2022-04-01
- Lead Sponsor
- Insel Gruppe AG, University Hospital Bern
- Target Recruit Count
- 37
- Registration Number
- NCT01126255
- Locations
- 🇨🇭
Dep. of Obstetrics and Gynecology, Bern University Hospital, Bern, Switzerland
Safety and Efficacy of Clobetasol Propionate 0.05% E Foam in Alopecia
- Conditions
- Alopecia
- First Posted Date
- 2010-04-28
- Last Posted Date
- 2010-04-28
- Lead Sponsor
- Callender Center for Clinical Research
- Target Recruit Count
- 30
- Registration Number
- NCT01111981
- Locations
- 🇺🇸
Callender Center for Clinical Research, Mitchellville, Maryland, United States
Safety and Efficacy Study of Combination Treatment With Excimer Laser, Clobex Spray, and Vectical Ointment in the Treatment of Psoriasis
- Conditions
- Chronic Stable Plaque Psoriasis
- Interventions
- First Posted Date
- 2009-11-13
- Last Posted Date
- 2015-06-18
- Lead Sponsor
- University of California, San Francisco
- Target Recruit Count
- 30
- Registration Number
- NCT01012713
- Locations
- 🇺🇸
UCSF Psoriasis and Skin Treatment Center, San Francisco, California, United States
Evaluate Safety/Efficacy of Two Treatment Regimens for Vectical™ Ointment & Clobex® Spray for Moderate Plaque Psoriasis
- Conditions
- Plaque Psoriasis
- Interventions
- Drug: Vectical™ Ointment weekdays and Clobex® Spray weekends regimen
- First Posted Date
- 2009-10-02
- Last Posted Date
- 2022-08-01
- Lead Sponsor
- Galderma R&D
- Target Recruit Count
- 138
- Registration Number
- NCT00988637
- Locations
- 🇺🇸
Dermatology Research Associates, Los Angeles, California, United States
🇺🇸Minnesota Clinical Study Center, Fridley, Minnesota, United States
🇺🇸Hudson Dermatology, Evansville, Indiana, United States
Clobetasol Propionate Spray Versus Vehicle Spray for the Management of Moderate to Severe Plaque Psoriasis of the Scalp
- Conditions
- Scalp Psoriasis
- Interventions
- Drug: Vehicle spray
- First Posted Date
- 2009-04-15
- Last Posted Date
- 2022-08-25
- Lead Sponsor
- Galderma R&D
- Target Recruit Count
- 81
- Registration Number
- NCT00881868
- Locations
- 🇺🇸
Hudson Dermatology, Evansville, Indiana, United States
🇺🇸Dermatology Associates, PLLC, Seattle, Washington, United States
🇺🇸Research Division of The Skin Specialty Group, New York, New York, United States
The Dose-response "Pilot" Study of Topically Delivered Clobetasol Propionate Lotion in Healthy Adult Subjects
- Conditions
- Healthy
- Interventions
- First Posted Date
- 2009-03-18
- Last Posted Date
- 2019-07-09
- Lead Sponsor
- Actavis Inc.
- Target Recruit Count
- 15
- Registration Number
- NCT00864240
- Locations
- 🇺🇸
Novum Pharmaceutical Research Services, Houston, Texas, United States
Drug Development Updates
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