Imatinib

Generic Name: Imatinib

Brand Names: Gleevec, Glivec, Imatinib Teva, Imatinib Accord

Drug Type: Small Molecule

Chemical Formula: C_₂₉H_₃₁N_₇O

CAS Number: 152459-95-5

Unique Ingredient Identifier: BKJ8M8G5HI

Background: Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated with a daily dosage of 300 mg or more and ...

Indication: Imatinib is indicated for the treatment of adult and pediatric chronic myeloid leukemia with Philadelphia chromosome mutation (Ph+) in blast crisis, accelerated phase, or chronic phase after IFN-alpha therapy failure.Additionally, imatinib is also indicated to treat adult and pediatric Ph+ acute lymphoblastic leukemia, adult myelodysplastic/myeloproliferativ...

Associated Conditions: Accelerated Phase Chronic Myelogenous Leukemia (CML), Aggressive Systemic Mastocytosis, Chordomas, Chronic Eosinophilic Leukemia, FIP1L1-PDGFRα fusion kinase status unknown Chronic eosinophilic leukemia, FIP1L1-PDGFRα fusion kinase status unknown Hypereosinophilic syndrome, Gastrointestinal Stromal Tumor (GIST), Hypereosinophilic Syndrome (HES), Metastatic Gastrointestinal Stromal Tumor (GIST), Metastatic Melanoma, Myelodysplastic Syndrome, Myeloproliferative Disorders (MPD), Refractory Acute Lymphoblastic Leukemia (ALL), Blast phase Chronic myeloid leukemia, CKit mutational status unknown Aggressive systemic mastocytosis, Metastatic Dermatofibrosarcoma protuberans, Newly diagnosed Acute Lymphoblastic Leukaemia, Newly diagnosed, chronic phase Chronic myeloid leukemia, Recurrent Dermatofibrosarcoma protuberans, Refractory, chronic phase Chronic myeloid leukemia, Unresectable Gastrointestinal stromal tumor

Associated Therapies: -

Clinical Trials

Radotinib Versus Imatinib in Newly Diagnosed Philadelphia Chromosome and Chronic Myeloid Leukemia Chronic Phase Patients

Phase 3

Completed

Conditions: Leukemia
Leukemia, Myeloid
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Philadelphia Chromosome
Bone Marrow Diseases
Hematologic Diseases

Interventions: Drug: Imatinib
Drug: Radotinib

First Posted Date: 2012-01-18

Last Posted Date: 2016-02-24

Lead Sponsor: Il-Yang Pharm. Co., Ltd.

Target Recruit Count: 242

Registration Number: NCT01511289

Locations: 🇹🇭
Local Institution, Bangkok, Thailand

A Phase II Study of Flumatinib Versus Imatinib to Treat Philadelphia Chromosome Positive Chronic Myelogenous Leukemia

Phase 2

Conditions: Myelogenous Leukemia, Chronic

Interventions: Drug: flumatinib
Drug: imatinib

First Posted Date: 2012-01-04

Last Posted Date: 2013-04-10

Lead Sponsor: Jiangsu HengRui Medicine Co., Ltd.

Target Recruit Count: 150

Registration Number: NCT01503502

Locations: 🇨🇳
Ruijin Hospital, Shanghai, Shanghai, China
🇨🇳
Peking University People's Hospital, Beijing, Beijing, China
🇨🇳
The First Rffiurted Hospital of Soochow University, Suzhou, Jiangsu, China

and more 2 locations

Chemotherapy and Imatinib in Young Adults With Acute Lymphoblastic Leukemia Ph (BCR-ABL) POSITIVE

Phase 4

Conditions: Acute Lymphoblastic Leukemia Ph Positive

First Posted Date: 2011-12-14

Last Posted Date: 2022-01-19

Lead Sponsor: PETHEMA Foundation

Target Recruit Count: 70

Registration Number: NCT01491763

Locations: 🇪🇸
Hospital general de Castellón, Castello, Castellón, Spain
🇪🇸
Hospital Germans Trias i Pujol and all Hospital Pethema, Badalona, Barcelona, Spain
🇪🇸
Hospital Central de Asturias, Oviedo, Asturias, Spain

and more 69 locations

Observational Study in Adults With Imatinib-resistant/Intolerant Chronic Myeloid Leukemia Treated With Nilotinib

Completed

Conditions: Chronic Myeloid Leukaemia

Interventions: Drug: Imatinib

First Posted Date: 2011-11-21

Last Posted Date: 2022-10-25

Lead Sponsor: Gruppo Italiano Malattie EMatologiche dell'Adulto

Target Recruit Count: 19

Registration Number: NCT01475110

Locations: 🇮🇹
Università degli Studi, Genova, Italy
🇮🇹
Federico II, Napoli, Italy
🇮🇹
Policlinico A. Gemelli - Universita Cattolica del Sacro Cuore, Rome, Italy

and more 25 locations