Methoxsalen
- Generic Name
- Methoxsalen
- Brand Names
- Oxsoralen, Uvadex
- Drug Type
- Small Molecule
- Chemical Formula
- C12H8O4
- CAS Number
- 298-81-7
- Unique Ingredient Identifier
- U4VJ29L7BQ
- Background
A naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia. It is a photoactive substance that forms DNA adducts in the presence of ultraviolet A irradiation.
- Indication
For the treatment of psoriasis and vitiligo
- Associated Conditions
- Cutaneous T-Cell Lymphoma (CTCL), Refractory Cutaneous T-cell Lymphoma, Vitiligo, Idiopathic Vitiligo, Severe Psoriasis
EPIC- Extracorporeal Photopheresis (ECP) for Immune-related Colitis
- Conditions
- Immune-related Colitis
- Interventions
- First Posted Date
- 2024-10-17
- Last Posted Date
- 2025-05-14
- Lead Sponsor
- Therakos LLC
- Target Recruit Count
- 30
- Registration Number
- NCT06646016
- Locations
- 🇺🇸
University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States
Steroids Versus ECP and Steroids as First-line Treatment of Grade II Acute GVHD
- First Posted Date
- 2023-11-15
- Last Posted Date
- 2023-11-15
- Lead Sponsor
- Central Hospital, Nancy, France
- Target Recruit Count
- 42
- Registration Number
- NCT06133192
- Locations
- 🇫🇷
CHRU de Nancy, Vandoeuvre Les Nancy, France
Photopheresis in Early-stage Mycosis Fungoides
- Conditions
- Cutaneous T Cell LymphomaMycosis Fungoides
- Interventions
- Device: THERAKOS® CELLEX photopheresis system
- First Posted Date
- 2023-01-11
- Last Posted Date
- 2024-06-05
- Lead Sponsor
- Columbia University
- Target Recruit Count
- 74
- Registration Number
- NCT05680558
- Locations
- 🇺🇸
Herbert Irving Pavilion, New York, New York, United States
Extracorporeal Photopheresis in Sezary Syndrome
- Conditions
- Sezary Syndrome
- Interventions
- Device: Extracorporeal photopheresis (ECP)
- First Posted Date
- 2021-12-15
- Last Posted Date
- 2025-01-08
- Lead Sponsor
- Oleg E. Akilov, MD, PhD
- Target Recruit Count
- 15
- Registration Number
- NCT05157581
- Locations
- 🇺🇸
University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States
Extracorporeal Photopheresis in Early Diffuse Cutaneous Systemic Sclerosis
- Conditions
- Diffuse Cutaneous Systemic Sclerosis
- Interventions
- Device: Extracorporeal Photopheresis (ECP)
- First Posted Date
- 2021-08-03
- Last Posted Date
- 2025-03-13
- Target Recruit Count
- 15
- Registration Number
- NCT04986605
- Locations
- 🇨🇦
Rheumatology Clinic, St. Joseph's Health Care, London, Ontario, Canada
Extracorporal Photopheresis with UVADEX Plus Standard Steroid Treatment for High Risk Acute Graft-versus-host Disease
- First Posted Date
- 2020-03-02
- Last Posted Date
- 2025-03-30
- Lead Sponsor
- Universitätsklinikum Hamburg-Eppendorf
- Target Recruit Count
- 24
- Registration Number
- NCT04291261
- Locations
- 🇦🇹
Medical University of Graz, Department of Internal Medicine, Graz, Austria
🇩🇪University Hospital Erlangen, Erlangen, Germany
🇩🇪University Medical Center Hamburg-Eppendorf, Hamburg, Germany
Study of Photopheresis in the Treatment of Erythrodermic MF and SS
- Conditions
- Lymphoma, T-Cell, CutaneousMycosis Fungoides/Sezary Syndrome
- Interventions
- Device: THERAKOS CELLEX Photopheresis System
- Locations
- 🇨🇭
UniversitaetsSpital Zurich - Division of Dermatology, Zürich, Switzerland
Methoxsalen and Extracorporeal Photopheresis (ECP) for the Treatment of Pediatric Participants With Steroid Refractory Acute Graft Versus Host Disease
- Conditions
- Steroid Refractory Acute Graft Versus Host Disease
- Interventions
- Procedure: Extracorporeal Photopheresis (ECP)
- First Posted Date
- 2015-08-17
- Last Posted Date
- 2020-09-11
- Lead Sponsor
- Therakos, Inc., a Mallinckrodt Company
- Target Recruit Count
- 29
- Registration Number
- NCT02524847
- Locations
- 🇺🇸
Hackensack University Medical Center, Hackensack, New Jersey, United States
🇺🇸Boston Children's Hospital, Boston, Massachusetts, United States
🇺🇸University Hospitals Rainbow Babies & Children's, Cleveland, Ohio, United States
Biomarkers in Acute Graft-Versus-Host Disease and Extracorporeal Photopheresis Added to Investigator Chosen Therapies of Steroid Refractory Acute GVHD
- Conditions
- Chronic Graft vs. Host DiseaseGraft vs Host DiseaseGraft-Versus-Host Disease
- Interventions
- Procedure: Extracorporeal Photopheresis (ECP)
- First Posted Date
- 2014-12-23
- Last Posted Date
- 2020-03-12
- Lead Sponsor
- National Cancer Institute (NCI)
- Target Recruit Count
- 5
- Registration Number
- NCT02322190
- Locations
- 🇺🇸
National Institutes of Health Clinical Center, 9000 Rockville Pike, Bethesda, Maryland, United States
PUVA Maintenance Therapy in Mycosis Fungoides
- First Posted Date
- 2012-09-18
- Last Posted Date
- 2018-11-14
- Lead Sponsor
- Medical University of Graz
- Target Recruit Count
- 28
- Registration Number
- NCT01686594
- Locations
- 🇦🇹
Department of Dermatology, Medical University of Vienna, Vienna, Austria
🇦🇹Department of Dermatology, Hospital Hietzing, Vienna, Austria
🇦🇹Department of Dermatology, Klinikum Wels, Wels, Austria
Drug Development Updates
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