Methoxsalen

Generic Name
Methoxsalen
Brand Names
Oxsoralen, Uvadex
Drug Type
Small Molecule
Chemical Formula
C12H8O4
CAS Number
298-81-7
Unique Ingredient Identifier
U4VJ29L7BQ
Background

A naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia. It is a photoactive substance that forms DNA adducts in the presence of ultraviolet A irradiation.

Indication

For the treatment of psoriasis and vitiligo

Associated Conditions
Cutaneous T-Cell Lymphoma (CTCL), Refractory Cutaneous T-cell Lymphoma, Vitiligo, Idiopathic Vitiligo, Severe Psoriasis
Associated Therapies
-
Clinical Trials
Related News

Safety and Efficacy of Extracorporeal Photoimmune Therapy With UVADEX for the Treatment of Rheumatoid Arthritis

Phase 2
Completed
Conditions
Rheumatoid Arthritis
First Posted Date
2005-09-22
Last Posted Date
2016-10-19
Lead Sponsor
Mallinckrodt
Target Recruit Count
86
Registration Number
NCT00221000
Locations
🇺🇸

Clinical Pharmacology Study Group, Worchester, Massachusetts, United States

🇮🇹

Universita de Genova - Ospedale S. Martino, Genova, Italy

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Carolina Arthritis Associates, Wilmington, North Carolina, United States

and more 29 locations

Safety and Efficacy Study of Photopheresis Plus Standard Therapy to Treat Chronic Graft-versus-Host Disease

Phase 2
Completed
Conditions
Graft-versus-Host Disease
First Posted Date
2003-02-06
Last Posted Date
2017-08-16
Lead Sponsor
Mallinckrodt
Target Recruit Count
72
Registration Number
NCT00054613
Locations
🇺🇸

University of Florida, Gainesville, Florida, United States

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University of Nebraska, Omaha, Nebraska, United States

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Ankara University Medical School, Altındağ, Ankara, Turkey

and more 28 locations

Safety and Efficacy Study of Photopheresis With UVADEX to Prevent Graft-versus-Host Disease

Phase 2
Completed
Conditions
Graft-versus-Host Disease
First Posted Date
2003-02-06
Last Posted Date
2017-08-16
Lead Sponsor
Mallinckrodt
Target Recruit Count
60
Registration Number
NCT00054600
Locations
🇺🇸

Tufts New England Medical Center, Boston, Massachusetts, United States

🇺🇸

University of Chicago, Chicago, Illinois, United States

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Kansas City Cancer Center, Kansas City, Missouri, United States

and more 17 locations

Chemotherapy and Photodynamic Therapy in Treating Patients With Cutaneous T-Cell Lymphoma

Phase 2
Conditions
Lymphoma
First Posted Date
2003-01-27
Last Posted Date
2013-12-18
Lead Sponsor
Millennix
Registration Number
NCT00030589
Locations
🇺🇸

Barbara Ann Karmanos Cancer Institute, Detroit, Michigan, United States

🇺🇸

University of Alabama at Birmingham Comprehensive Cancer Center, Birmingham, Alabama, United States

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University of Colorado Health Science Center, Aurora, Colorado, United States

and more 14 locations

The Therakos UVAR Photopheresis System in the Treatment of AIDS-Related Complex

Not Applicable
Completed
Conditions
HIV Infections
First Posted Date
2001-08-31
Last Posted Date
2005-06-24
Lead Sponsor
Mallinckrodt
Registration Number
NCT00002011
Locations
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Morristown Memorial Hosp, Morristown, New Jersey, United States

Phase II Pilot Study of Extracorporeal Phototherapy for Epidermolysis Bullosa Acquisita

Phase 2
Completed
Conditions
Epidermolysis Bullosa Acquisita
First Posted Date
1999-10-19
Last Posted Date
2005-06-24
Lead Sponsor
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Target Recruit Count
10
Registration Number
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