Overview
Dimethicone is a silicone oil that is also known as polydimethylsiloxane (PDMS). It has viscoelastic properties. Dimethicone is used as a surfactant, antifoaming agent, carminative in various products such as medical devices, food products, and lubricants. It is used in a number of health and beauty products including hair care products such as shampoo, conditioner, leave-in conditioner, and de-tangling products. On skin, it is also observed to have moisturizing actions . A study found that that the 100 % dimethicone product is a safe and highly effective head lice treatment for children and may serve as less toxic and less resistance-prone alternative to pesticide-containing products .
Background
Dimethicone is a silicone oil that is also known as polydimethylsiloxane (PDMS). It has viscoelastic properties. Dimethicone is used as a surfactant, antifoaming agent, carminative in various products such as medical devices, food products, and lubricants. It is used in a number of health and beauty products including hair care products such as shampoo, conditioner, leave-in conditioner, and de-tangling products. On skin, it is also observed to have moisturizing actions . A study found that that the 100 % dimethicone product is a safe and highly effective head lice treatment for children and may serve as less toxic and less resistance-prone alternative to pesticide-containing products .
Indication
Dimethicone is a colorless liquid with both cosmetic and therapeutic uses. It is used in topical creams and ointments to help distribute the active ingredients. Dimethicone is used as an anti-foaming agent, a hair and skin conditioner, and in the treatment of head lice and, as an anti-bloating/anti-flatulence agent , .
Associated Conditions
- Acute Diarrhea
- Aerophagy
- Dry Skin
- Duodenal Ulcer
- Dyspepsia
- Flatulence
- Gastric Ulcer
- Gastritis
- Gastro-esophageal Reflux Disease (GERD)
- Hiatus Hernia
- Pancreatic Insufficiency
- Post Operative Gas
- Pre-operative Gas
- Stress Ulcers
Clinical Trials
Title | Posted | Study ID | Phase | Status | Sponsor |
|---|---|---|---|---|---|
2024/12/09 | Phase 2 | Active, not recruiting | Healthgen Biotechnology Corp. | ||
2024/12/03 | Not Applicable | Recruiting | |||
2024/02/05 | Phase 4 | Recruiting | |||
2016/01/21 | Phase 3 | Completed | |||
2013/08/02 | Phase 2 | Completed | |||
2008/06/23 | Phase 2 | Completed |
FDA Drug Approvals
Approved Product | Manufacturer | NDC Code | Route | Strength | Effective Date |
|---|---|---|---|---|---|
| TARGET CORPORATION | 11673-066 | ORAL | 125 mg in 1 1 | 4/11/2025 | |
| Jiangxi Hemei Pharmaceutical Co., Ltd | 84010-122 | TOPICAL | 2 g in 100 g | 5/25/2025 | |
| The Mentholatum Company | 10742-8745 | TOPICAL | 20 mg in 1 g | 5/2/2025 | |
| Amerisource Bergen | 46122-620 | ORAL | 125 mg in 1 1 | 4/8/2025 | |
| Retail Business Services, LLC | 72476-619 | TOPICAL | 13 mg in 1 mL | 3/24/2025 | |
| PHARMAMED USA INC | 84289-408 | TOPICAL | 1.8 g in 100 g | 3/18/2025 | |
| ATLANTIC BIOLOGICALS CORP | 17856-1141 | ORAL | 20 mg in 0.3 mL | 5/28/2025 | |
| Renu Laboratories, LLC | 76348-580 | TOPICAL | 3.36 g in 168 g | 4/18/2025 | |
| Geri-Care Pharmaceuticals, Corp | 57896-004 | ORAL | 20 mg in 5 mL | 3/31/2025 | |
| ATLANTIC BIOLOGICALS CORP. | 17856-0630 | ORAL | 20 mg in 5 mL | 5/12/2025 |
EMA Drug Approvals
Approved Product | Authorization Holder | Status | Issued Date |
|---|---|---|---|
| No EMA approvals found for this drug. | |||
HSA Drug Approvals
Approved Product | Manufacturer | Approval Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| VERAGEL-DMS TABLET | SIN02547P | TABLET | 10 mg | 4/19/1989 | |
| GASCOAL TABLET 50 mg | SIN07758P | TABLET | 50 mg | 7/1/1994 | |
| MACGEL TABLET | SIN08119P | TABLET | 25 mg | 4/11/1995 | |
| ENZYPLEX TABLET | SIN06211P | ENTERIC COATED TABLET | 25 mg | 5/3/1991 | |
| GERSKIN TABLET | SIN07893P | TABLET | 20 mg | 10/31/1994 |
NMPA Drug Approvals
Approved Product | Company | Approval Number | Drug Type | Dosage Form | Approval Date |
|---|---|---|---|---|---|
| Dimethicone Powder | 国药准字H51023869 | 化学药品 | 散剂 | 3/27/2020 | |
| Dimethicone Powder | 国药准字H20183250 | 化学药品 | 散剂 | 3/22/2023 | |
| Dimethicone Powder | 国药准字H20183251 | 化学药品 | 散剂 | 3/22/2023 | |
| Dimethicone Aerosol | 国药准字H51021906 | 化学药品 | 气雾剂 | 6/4/2020 | |
| Dimethicone Tablets | 四川蜀中药业有限公司 | 国药准字H51020746 | 化学药品 | 片剂 | 10/28/2020 |
| Dimethicone Tablets | 国药准字H51021603 | 化学药品 | 片剂 | 8/12/2020 | |
| Dimethicone Tablets | 国药准字H19993776 | 化学药品 | 片剂 | 4/7/2024 | |
| Dimethicone Tablets | 国药准字H50020633 | 化学药品 | 片剂 | 7/13/2020 | |
| Dimethicone Tablets | 国药准字H50020634 | 化学药品 | 片剂 | 7/13/2020 | |
| Dimethicone Tablets | 国药准字H51020747 | 化学药品 | 片剂 | 4/15/2020 |
PPB Drug Approvals
Approved Product | Registration No. | Company | Licence No. | Strength | Registration Date |
|---|---|---|---|---|---|
| DIMETHICONE TAB 40MG (JEN SHENG) | N/A | N/A | N/A | 8/8/2001 |
TGA Drug Approvals
Approved Product | ARTG ID | Sponsor | Registration Type | Status | Registration Date |
|---|---|---|---|---|---|
| No TGA approvals found for this drug. | |||||