Dimethicone

Overview

Dimethicone is a silicone oil that is also known as polydimethylsiloxane (PDMS). It has viscoelastic properties. Dimethicone is used as a surfactant, antifoaming agent, carminative in various products such as medical devices, food products, and lubricants. It is used in a number of health and beauty products including hair care products such as shampoo, conditioner, leave-in conditioner, and de-tangling products. On skin, it is also observed to have moisturizing actions . A study found that that the 100 % dimethicone product is a safe and highly effective head lice treatment for children and may serve as less toxic and less resistance-prone alternative to pesticide-containing products .

Indication

Dimethicone is a colorless liquid with both cosmetic and therapeutic uses. It is used in topical creams and ointments to help distribute the active ingredients. Dimethicone is used as an anti-foaming agent, a hair and skin conditioner, and in the treatment of head lice and, as an anti-bloating/anti-flatulence agent , .

Associated Conditions

Acute Diarrhea
Aerophagy
Dry Skin
Duodenal Ulcer
Dyspepsia
Flatulence
Gastric Ulcer
Gastritis
Gastro-esophageal Reflux Disease (GERD)
Hiatus Hernia
Pancreatic Insufficiency
Post Operative Gas
Pre-operative Gas
Stress Ulcers

Clinical Trials

Title	Posted	Study ID	Phase	Status	Sponsor
Efficacy and Safety of OsrhCT and Dimethicone Emulsion Before Upper Endoscopy on Visualization of the Gastric Mucosa.	2024/12/09	NCT06722664	Phase 2	Active, not recruiting	Healthgen Biotechnology Corp.
Effect of Premedication With Pronase on Mucosal Cleanliness During EGD	2024/12/03	NCT06713421	Not Applicable	Recruiting	Changhai Hospital
Famotidine and Antacids for Treatment of Dyspepsia	2024/02/05	NCT06241183	Phase 4	Recruiting	Stony Brook University
Efficacy and Safety of Two Simeticone Brands in Adults With Functional Dyspepsia	2016/01/21	NCT02660372	Phase 3	Completed	Johnson & Johnson Consumer and Personal Products Worldwide
Parallel Group Trial to Evaluate the Efficacy and Safety of Loion® Compared to 10% Salicylic Acid in Patients With Chronic Psoriasis Capitis	2013/08/02	NCT01914627	Phase 2	Completed	G. Pohl-Boskamp GmbH & Co. KG
Validation of Patient-reported Outcomes Measures for the Assessment of Gastroesophageal Reflux Disease (GERD) Symptoms	2008/06/23	NCT00703534	Phase 2	Completed	AstraZeneca

FDA Drug Approvals

Approved Product	Manufacturer	NDC Code	Route	Strength	Effective Date
Gas Relief - Cherry Flavor	TARGET CORPORATION	11673-066	ORAL	125 mg in 1 1	4/11/2025
HEALSURE SKIN PROTECTANT	Jiangxi Hemei Pharmaceutical Co., Ltd	84010-122	TOPICAL	2 g in 100 g	5/25/2025
Softlips Oasis Pineapple Coconut	The Mentholatum Company	10742-8745	TOPICAL	20 mg in 1 g	5/2/2025
good neighbor pharmacy anti diarrheal anti gas	Amerisource Bergen	46122-620	ORAL	125 mg in 1 1	4/8/2025
Daily Moisturizing	Retail Business Services, LLC	72476-619	TOPICAL	13 mg in 1 mL	3/24/2025
Curist Gas Relief	Little Pharma. Inc.	72559-041	ORAL	180 mg in 180 mg	7/6/2025
PROSKI SHIELD	PHARMAMED USA INC	84289-408	TOPICAL	1.8 g in 100 g	3/18/2025
TEENY TUMMY Gas Relief Drops	ATLANTIC BIOLOGICALS CORP	17856-1141	ORAL	20 mg in 0.3 mL	5/28/2025
pediadermics eczema 3	Renu Laboratories, LLC	76348-580	TOPICAL	3.36 g in 168 g	4/18/2025
KO-LANTA	Geri-Care Pharmaceuticals, Corp	57896-004	ORAL	20 mg in 5 mL	3/31/2025

EMA Drug Approvals

Approved Product	Authorization Holder	Status	Issued Date
No EMA approvals found for this drug.

HSA Drug Approvals

Approved Product	Manufacturer	Approval Number	Dosage Form	Strength	Approval Date
VERAGEL-DMS TABLET	UNILAB, INC	SIN02547P	TABLET	10 mg	4/19/1989
GASCOAL TABLET 50 mg	Y S P INDUSTRIES (M) SDN BHD	SIN07758P	TABLET	50 mg	7/1/1994
MACGEL TABLET	Y S P INDUSTRIES (M) SDN BHD	SIN08119P	TABLET	25 mg	4/11/1995
ENZYPLEX TABLET	PT MEDIFARMA LABORATORIES INC	SIN06211P	ENTERIC COATED TABLET	25 mg	5/3/1991
GERSKIN TABLET	Y S P INDUSTRIES (M) SDN BHD	SIN07893P	TABLET	20 mg	10/31/1994

NMPA Drug Approvals

Approved Product	Company	Approval Number	Drug Type	Dosage Form	Approval Date
No NMPA approvals found for this drug.

PPB Drug Approvals

Approved Product	Registration No.	Company	Licence No.	Strength	Registration Date
DIMETHICONE TAB 40MG (JEN SHENG)	N/A	LANWAY LIMITED	N/A	N/A	8/8/2001

TGA Drug Approvals

Approved Product	ARTG ID	Sponsor	Registration Type	Status	Registration Date
No TGA approvals found for this drug.

Health Canada Drug Approvals

Approved Product	Company	DIN	Dosage Form	Strength	Market Date
SELAN +	span-america medical systems inc.	02489643	Cream - Topical	2.1 % / W/W	N/A
NUTRASHIELD	MEDLINE INDUSTRIES, LP	02291614	Cream - Topical	1.0 %	2/8/2010
CLEAN N MOIST - ASP-LIQ 1.5%	hollister limited	02144638	Liquid , Spray - Topical	1.5 %	12/31/1955
PHAZYME LIQUID 40MG/0.6ML	reed & carnrick, division of block drug company (canada) ltd.	01932276	Liquid - Oral	40 MG / .6 ML	12/31/1993
CLEANSING BODY LOTION	MEDLINE INDUSTRIES, LP	02291592	Lotion - Topical	1.5 % / W/W	2/8/2010
ANTACID LIQUID SUSP	shoppers drug mart inc.	00417920	Suspension - Oral	25 MG / 5 ML	12/31/1977
BABYS OWN TUMMY TAB	G.T. Fulford Pharmaceuticals	00397083	Tablet - Oral	2 MG / TAB	12/31/1977
BABY'S OWN INFANT DROPS - 40MG/0.6ML	block drug company (canada) ltd.	02227606	Drops - Oral	40 MG / .6 ML	1/17/1997
OVOL 160MG CHEWABLE TABLETS	carter-horner corp.	02013576	Tablet - Oral	160 MG	12/31/1994
MOISTUREL SENSITIVE SKIN LOTION	glaxosmithkline consumer healthcare ulc	01909169	Lotion - Topical	3 % / W/W	12/31/1991

CIMA AEMPS Drug Approvals

Approved Product	Company	Registration Number	Pharmaceutical Form	Prescription Type	Status
AEROFLAT 5 mg/ 77,5 mg COMPRIMIDOS MASTICABLES	Viatris Healthcare Limited	53610	COMPRIMIDO MASTICABLE	Medicamento Sujeto A Prescripción Médica	Not Commercialized
PANKREOFLAT 172 MG/80 MG COMPRIMIDOS RECUBIERTOS	Faes Farma S.A.	44633	COMPRIMIDO	Sin Receta	Commercialized

Philippines FDA Drug Approvals

Approved Product	Company	License Number	Dosage Form	Strength	Approval Date
No Philippines FDA approvals found for this drug.

Saudi SFDA Drug Approvals

Approved Product	Company	License Number	Dosage Form	Strength	Approval Date
No Saudi SFDA approvals found for this drug.

Malaysia NPRA Drug Approvals

Approved Product	Company	Registration Number	Dosage Form	Strength	Approval Date
No Malaysia NPRA approvals found for this drug.

UK EMC Drug Information

Medicine Name	MA Holder	MA Number	Pharmaceutical Form	Active Ingredient	Authorization Date
No UK EMC drug information found for this drug.

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