Overview
Enfuvirtide is a 36 amino acid biomimetic peptide that is structurally similar to the HIV proteins that are responsible for the fusion of the virus to cell membranes and subsequent intracellular uptake. The first agent in the novel class of antiretroviral drugs called HIV fusion inhibitors, enfuvirtide works by inhibiting HIV-1 fusion with CD4 cells.
Background
Enfuvirtide is a 36 amino acid biomimetic peptide that is structurally similar to the HIV proteins that are responsible for the fusion of the virus to cell membranes and subsequent intracellular uptake. The first agent in the novel class of antiretroviral drugs called HIV fusion inhibitors, enfuvirtide works by inhibiting HIV-1 fusion with CD4 cells.
Indication
Enfuvirtide is an antiretroviral drug used in combination therapy for the treatment of HIV-1/AIDS.
Associated Conditions
- Human Immunodeficiency Virus Type 1 (HIV-1)
Clinical Trials
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Title | Posted | Study ID | Phase | Status | Sponsor |
|---|---|---|---|---|---|
2005/08/10 | Phase 2 | Completed | Tibotec Pharmaceuticals, Ireland | ||
2005/07/18 | Phase 2 | Completed | French National Agency for Research on AIDS and Viral Hepatitis | ||
2005/01/10 | Phase 4 | Terminated | |||
2004/08/06 | Phase 2 | Completed | |||
2004/07/13 | Phase 1 | Completed | |||
2003/01/20 | Not Applicable | Completed | |||
2002/12/24 | Phase 3 | Completed | |||
2002/02/22 | Phase 1 | Completed | |||
2001/08/31 | Phase 2 | Completed | |||
2001/08/31 | Phase 1 | Completed |
FDA Drug Approvals
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Approved Product | Manufacturer | NDC Code | Route | Strength | Effective Date |
|---|---|---|---|---|---|
| No FDA approvals found for this drug. | |||||
EMA Drug Approvals
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|---|---|---|---|
| No EMA approvals found for this drug. | |||
HSA Drug Approvals
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NMPA Drug Approvals
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PPB Drug Approvals
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| No PPB approvals found for this drug. | |||||
TGA Drug Approvals
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| No TGA approvals found for this drug. | |||||