Levothyroxine
- Generic Name
- Levothyroxine
- Brand Names
- Eltroxin, Ermeza, Euthyrox, Levo-T, Levothroid, Levoxyl, Np Thyroid, Synthroid, Thyquidity, Tirosint, Unithroid
- Drug Type
- Small Molecule
- Chemical Formula
- C15H11I4NO4
- CAS Number
- 51-48-9
- Unique Ingredient Identifier
- Q51BO43MG4
- Background
Levothyroxine is a synthetically produced form of thyroxine, a major endogenous hormone secreted by the thyroid gland. Also known as L-thyroxine or the brand name product Synthroid, levothyroxine is used primarily to treat hypothyroidism, a condition where the thyroid gland is no longer able to produce sufficient quantities of the thyroid hormones T (tetraio...
- Indication
Levothyroxine is indicated as replacement therapy in primary (thyroidal), secondary (pituitary) and tertiary (hypothalamic) congenital or acquired hypothyroidism. It is also indicated as an adjunct to surgery and radioiodine therapy in the management of thyrotropin-dependent well-differentiated thyroid cancer.
- Associated Conditions
- Edematous Fibrosclerotic Panniculopathy (Cellulite), Hypothyroidism, Localized Adiposity, Myxedema coma, Euthyroid Goitre, Thyrotropin dependent Well-Differentiated Thyroid Cancer
- Associated Therapies
- -
Study to Evaluate the Effect of IW-3718 on the Pharmacokinetics of Oral Contraceptive, Levothyroxine, Glyburide, and Digoxin in Healthy Adult Volunteers
- Conditions
- Interventions
- First Posted Date
- 2019-02-27
- Last Posted Date
- 2019-07-29
- Lead Sponsor
- Ironwood Pharmaceuticals, Inc.
- Target Recruit Count
- 87
- Registration Number
- NCT03856970
- Locations
- 🇺🇸
PPD, Austin, Texas, United States
Thyroxin in Subclinical Hypothyroidism
- Conditions
- Interventions
- First Posted Date
- 2018-10-19
- Last Posted Date
- 2018-10-29
- Lead Sponsor
- Hawler Medical University
- Target Recruit Count
- 168
- Registration Number
- NCT03712683
Identification of Non-responders to Levothyroxine Therapy
- Conditions
- Interventions
- First Posted Date
- 2018-08-13
- Last Posted Date
- 2021-03-17
- Lead Sponsor
- Oslo University Hospital
- Target Recruit Count
- 69
- Registration Number
- NCT03627611
- Locations
- 🇳🇴
Oslo University Hospital, Oslo, Norway
Efficacy of Low Dose Levothyroxine During Pregnancy
- First Posted Date
- 2018-01-05
- Last Posted Date
- 2021-10-07
- Lead Sponsor
- Ain Shams University
- Target Recruit Count
- 180
- Registration Number
- NCT03391154
- Locations
- 🇪🇬
AinShams university maternity hospital, Cairo, Abbassya, Egypt
Thyroxine Treatment in Premature Infants With Intraventricular Hemorrhage
- Conditions
- Interventions
- First Posted Date
- 2018-01-04
- Last Posted Date
- 2022-07-08
- Lead Sponsor
- Albert Einstein College of Medicine
- Registration Number
- NCT03390530
- Locations
- 🇺🇸
Praveen Ballabh, Bronx, New York, United States
The Role of Immunomodulatory Treatment in Success of ICSI in Patients With Autoimmune Thyroiditis
- Conditions
- Interventions
- First Posted Date
- 2017-09-21
- Last Posted Date
- 2020-06-22
- Lead Sponsor
- Aljazeera Hospital
- Target Recruit Count
- 100
- Registration Number
- NCT03289403
- Locations
- 🇪🇬
Aljazeera (Al Gazeera) hospital, Giza, Egypt
Levothyroxine for Non-Alcoholic Fatty Liver Disease (NAFLD)
- Conditions
- Interventions
- First Posted Date
- 2017-09-13
- Last Posted Date
- 2017-09-14
- Lead Sponsor
- Duke-NUS Graduate Medical School
- Target Recruit Count
- 29
- Registration Number
- NCT03281083
A Pilot Feasibility Trial of Thyroid Hormone Replacement in Dialysis Patients
- Conditions
- Interventions
- First Posted Date
- 2017-06-19
- Last Posted Date
- 2021-06-14
- Lead Sponsor
- University of California, Irvine
- Target Recruit Count
- 96
- Registration Number
- NCT03191188
- Locations
- 🇺🇸
University Dialysis Center of Orange, Orange, California, United States
Wound Complications in Head and Neck Surgery
- Conditions
- Interventions
- First Posted Date
- 2017-05-01
- Last Posted Date
- 2020-06-01
- Lead Sponsor
- University of Michigan
- Target Recruit Count
- 51
- Registration Number
- NCT03134976
- Locations
- 🇺🇸
University of Michigan, Ann Arbor, Michigan, United States
Safety and Efficacy of Empiric Levothyroxine (LT4) Dose Increase Versus Individualized LT4 Dose Increase in Hypothyroid Women During Pregnancy
- First Posted Date
- 2017-04-14
- Last Posted Date
- 2018-03-29
- Lead Sponsor
- Medstar Health Research Institute
- Target Recruit Count
- 60
- Registration Number
- NCT03115515
- Locations
- 🇺🇸
Medstar Washington Hospital Center, Washington, District of Columbia, United States
Drug Development Updates
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