Acetaminophen

Generic Name: Acetaminophen

Brand Names: Acephen, Acetadryl, Allzital, Apadaz, Arthriten Inflammatory Pain, Bupap, Butapap, Cetafen, Children's Silapap, Coricidin Hbp Cold & Flu, Darvocet-N, Dayquil Sinex, Diphen, Dolofin, Dologen, Dologesic Reformulated Jun 2016, Duralgina, Dvorah, Endocet, Esgic, Exaprin, Excedrin, Excedrin PM Triple Action, Excedrin Tension Headache, Feverall, Fioricet, Fioricet With Codeine, Goody's Back & Body Pain Relief, Goody's Body Pain, Goody's Extra Strength, Goody's Headache Relief Shot, Goody's PM, Hycet, Legatrin PM, Little Fevers, Lorcet, Lortab, Mapap, Mersyndol, Midol Complete, Midol Cramps & Bodyaches, Nalocet, Norco, Orbivan, Pamprin Max Formula, Pamprin Multi-symptom, Panadol, Pediacare Children's Fever Reducer Pain Reliever, Percocet, Percogesic Reformulated Jan 2011, Pharbetol, Premsyn Pms, Prolate, Rivacocet, Robaxacet, Robaxacet-8, Roxicet, Sudafed PE Sinus Headache, Tactinal, Tencon, Trezix, Triatec, Triatec-30, Triatec-8, Tylenol, Tylenol PM, Tylenol With Codeine, Ultracet, Vanatol, Vanatol S, Vanquish, Xodol, Xolox, Zamicet, Zflex, Zydone

Drug Type: Small Molecule

Chemical Formula: C_₈H_₉NO_₂

CAS Number: 103-90-2

Unique Ingredient Identifier: 362O9ITL9D

Background: Acetaminophen (paracetamol), also commonly known as Tylenol, is the most commonly taken analgesic worldwide and is recommended as first-line therapy in pain conditions by the World Health Organization (WHO). It is also used for its antipyretic effects, helping to reduce fever. This drug was initially approved by the U.S. FDA in 1951 and is available in a var...

Indication: In general, acetaminophen is used for the treatment of mild to moderate pain and reduction of fever. It is available over the counter in various forms, the most common being oral forms.
...

Associated Conditions: Acute Gouty Arthritis, Acute Musculoskeletal Pain, Allergic Reaction, Allergy to Tree Pollen, Ankylosing Spondylitis (AS), Chills, Cold, Common Cold, Cough, Cough caused by Common Cold, Coughing caused by Flu caused by Influenza, Dyskinesia of the Biliary Tract, Dyskinesia of the Urinary Tract, Febrile Convulsions, Febrile Illness Acute, Fever, Fibromyalgia, Flu caused by Influenza, Headache, Joint dislocations, Menstrual Distress (Dysmenorrhea), Mild pain, Muscle Inflammation, Muscle Injuries, Muscle Spasms, Musculoskeletal Pain, Myalgia, Nasal Congestion, Neuropathic Pain, Osteoarthritis (OA), Pain, Postoperative pain, Premenstrual cramps, Rheumatoid Arthritis, Rhinopharyngitis, Rhinorrhoea, Severe Pain, Sinusitis, Spasms, Spastic Pain of the Gastrointestinal Tract, Sprains, Symptoms Cold, Tension Headache, Toothache, Upper Respiratory Tract Infection, Whiplash Syndrome, Acute Torticollis, Articular inflammation, Cold or flu syndrome, Mild to moderate pain, Minor aches and pains, Minor pain, Moderate Pain, Moderate to severe pain

Associated Therapies: Airway secretion clearance therapy, Anti-spasmodics, Bronchodilation

Clinical Trials

PARASTOP - Paracetamol With Strong Opioids

Phase 3

Recruiting

Conditions: Cancer Pain
Cancer

Interventions: Drug: Paracetamol
Drug: Placebo

First Posted Date: 2021-09-21

Last Posted Date: 2024-11-19

Lead Sponsor: Oslo University Hospital

Target Recruit Count: 204

Registration Number: NCT05051735

Locations: 🇺🇬
Makere University Hospital, Kampala, Uganda
🇮🇹
Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy
🇳🇴
Østfold Hospital Trust, Sarpsborg, Grålum, Norway

and more 12 locations

Analgesic Effect of Paracetamol in Patients With Femur Fracture: is Intravenous Better Than Oral?

Completed

Conditions: Femur Fracture

Interventions: Drug: Paracetamol

First Posted Date: 2021-08-27

Last Posted Date: 2021-10-11

Lead Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Target Recruit Count: 170

Registration Number: NCT05025228

Locations: 🇮🇹
Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, Roma, Italy

Melphalan on Disease Burden Measured by Next Generation Sequencing Before AHCT (Autologous Hematopoietic Cell Transplant) for Multiple Myeloma

Early Phase 1

Withdrawn

Conditions: Multiple Myeloma

Interventions: Drug: Evomela
Device: Next Generation Sequencing
Drug: Prochlorperazine
Drug: Acetaminophen
Drug: Diphenhydramine

First Posted Date: 2021-08-19

Last Posted Date: 2024-04-02

Lead Sponsor: Koen van Besien

Registration Number: NCT05013437

Locations: 🇺🇸
University Hospitals Cleveland Medical Center, Case Comprehensive Cancer Center, Cleveland, Ohio, United States

Intranasal Dexmedetomidine Versus Oral Paracetamol as a Pre-anaesthetic Medication in Pediatric Age Group

Phase 2

Completed

Conditions: Anxiety

Interventions: Drug: Dexmedetomidine
Drug: paracetamol

First Posted Date: 2021-07-02

Last Posted Date: 2022-05-06

Lead Sponsor: Benha University

Target Recruit Count: 86

Registration Number: NCT04949477

Locations: 🇪🇬
Banha Faculity of Medicine, Banhā, Elqalyoubea, Egypt

Opioid-Free Pain Control Regiment Following Robotic Radical Prostatectomy

Phase 2

Withdrawn

Conditions: Radical Prostatectomies

Interventions: Drug: Tramadol
Drug: Gabapentin
Drug: Hydrocodone-Acetaminophen
Drug: Ketorolac
Drug: Oxycodone-Acetaminophen
Drug: Acetaminophen
Drug: Ketorolac tromethamine
Drug: Ketamine

First Posted Date: 2021-06-25

Last Posted Date: 2022-09-06

Lead Sponsor: Wake Forest University Health Sciences

Registration Number: NCT04939987

Locations: 🇺🇸
Wake Forest Health Sciences, Winston-Salem, North Carolina, United States

PECs Block for Pacemaker Insertion in Children

Phase 4

Completed

Conditions: Complete Heart Block

Interventions: Drug: paracetamol
Procedure: modifiedPECs block

First Posted Date: 2021-06-18

Last Posted Date: 2022-10-20

Lead Sponsor: Kasr El Aini Hospital

Target Recruit Count: 40

Registration Number: NCT04931693

Locations: 🇪🇬
Kasr Al Ainy Hospital, Cairo, Egypt

Early Treatment of Vulnerable Individuals With Non-Severe SARS-CoV-2 Infection

Phase 2

Conditions: Covid19
Covid19 Drug Treatment
SARS-CoV2 Infection
Severe Acute Respiratory Syndrome Coronavirus 2

Interventions: Drug: Nitazoxanide and Ciclésonide
Drug: Telmisartan 20Mg Oral Tablet
Drug: Fluoxétine and Budésonide
Drug: Paracetamol

First Posted Date: 2021-06-10

Last Posted Date: 2023-01-31

Lead Sponsor: ANRS, Emerging Infectious Diseases

Target Recruit Count: 600

Registration Number: NCT04920838

Locations: 🇬🇳
Centre de traitement des maladies à tendance épidémique de Gbessia, Conakry, Guinea
🇧🇫
Centre Muraz/INSP, Bobo-Dioulasso, Burkina Faso

Elotuzumab in Immunoglobulin G4-Related Disease (IgG4-RD)

Phase 2

Terminated

Conditions: IgG4 Related Disease
IgG4-RD

Interventions: Drug: placebo for elotuzumab
Drug: elotuzumab
Drug: methylprednisolone
Drug: diphenhydramine
Drug: acetaminophen
Drug: famotidine
Drug: prednisone

First Posted Date: 2021-06-08

Last Posted Date: 2024-01-11

Lead Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Target Recruit Count: 8

Registration Number: NCT04918147

Locations: 🇺🇸
Massachusetts General Hospital, Boston, Massachusetts, United States
🇺🇸
Mayo Clinic: Pulmonary and Critical Care Medicine, Rochester, Minnesota, United States
🇺🇸
Emory Healthcare, Atlanta, Georgia, United States

Acetaminophen and AKI After Aortic Surgery

Not Applicable

Recruiting

Conditions: Aortic Surgery

Interventions: Other: Placebo
Drug: Acetaminophen

First Posted Date: 2021-05-11

Last Posted Date: 2024-02-07

Lead Sponsor: Gangnam Severance Hospital

Target Recruit Count: 136

Registration Number: NCT04882202

Locations: 🇰🇷
Gangnam Severance Hospital, Seoul, Korea, Republic of

Post-operative Course of Dexamethasone to Reduce Tonsillectomy Morbidity

Phase 3

Terminated

Conditions: Adenotonsillectomy
Analgesia
Surgery

Interventions: Drug: Dexamethasone
Drug: Ibuprofen
Drug: Placebo
Drug: Acetaminophen

First Posted Date: 2021-05-10

Last Posted Date: 2024-01-17

Lead Sponsor: David Chi, MD

Target Recruit Count: 215

Registration Number: NCT04879823

Locations: 🇺🇸
UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, United States
🇺🇸
Children's Hospital North Surgery Center, Sewickley, Pennsylvania, United States

Drug Development Updates

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