Acetaminophen

Generic Name
Acetaminophen
Brand Names
Acephen, Acetadryl, Allzital, Apadaz, Arthriten Inflammatory Pain, Bupap, Butapap, Cetafen, Children's Silapap, Coricidin Hbp Cold & Flu, Darvocet-N, Dayquil Sinex, Diphen, Dolofin, Dologen, Dologesic Reformulated Jun 2016, Duralgina, Dvorah, Endocet, Esgic, Exaprin, Excedrin, Excedrin PM Triple Action, Excedrin Tension Headache, Feverall, Fioricet, Fioricet With Codeine, Goody's Back & Body Pain Relief, Goody's Body Pain, Goody's Extra Strength, Goody's Headache Relief Shot, Goody's PM, Hycet, Legatrin PM, Little Fevers, Lorcet, Lortab, Mapap, Mersyndol, Midol Complete, Midol Cramps & Bodyaches, Nalocet, Norco, Orbivan, Pamprin Max Formula, Pamprin Multi-symptom, Panadol, Pediacare Children's Fever Reducer Pain Reliever, Percocet, Percogesic Reformulated Jan 2011, Pharbetol, Premsyn Pms, Prolate, Rivacocet, Robaxacet, Robaxacet-8, Roxicet, Sudafed PE Sinus Headache, Tactinal, Tencon, Trezix, Triatec, Triatec-30, Triatec-8, Tylenol, Tylenol PM, Tylenol With Codeine, Ultracet, Vanatol, Vanatol S, Vanquish, Xodol, Xolox, Zamicet, Zflex, Zydone
Drug Type
Small Molecule
Chemical Formula
C8H9NO2
CAS Number
103-90-2
Unique Ingredient Identifier
362O9ITL9D
Background

Acetaminophen (paracetamol), also commonly known as Tylenol, is the most commonly taken analgesic worldwide and is recommended as first-line therapy in pain conditions by the World Health Organization (WHO). It is also used for its antipyretic effects, helping to reduce fever. This drug was initially approved by the U.S. FDA in 1951 and is available in a variety of forms including syrup form, regular tablets, effervescent tablets, injection, suppository, and other forms.

Acetaminophen is often found combined with other drugs in more than 600 over the counter (OTC) allergy medications, cold medications, sleep medications, pain relievers, and other products. Confusion about dosing of this drug may be caused by the availability of different formulas, strengths, and dosage instructions for children of different ages. Due to the possibility of fatal overdose and liver failure associated with the incorrect use of acetaminophen, it is important to follow current and available national and manufacturer dosing guidelines while this drug is taken or prescribed.

Indication

In general, acetaminophen is used for the treatment of mild to moderate pain and reduction of fever. It is available over the counter in various forms, the most common being oral forms.

Acetaminophen injection is indicated for the management of mild to moderate pain, the management of moderate to severe pain with adjunctive opioid analgesics, and the reduction of fever.

Because of its low risk of causing allergic reactions, this drug can be administered in patients who are intolerant to salicylates and those with allergic tendencies, including bronchial asthmatics. Specific dosing guidelines should be followed when administering acetaminophen to children.

Associated Conditions
Acute Gouty Arthritis, Acute Musculoskeletal Pain, Allergic Reaction, Allergy to Tree Pollen, Ankylosing Spondylitis (AS), Chills, Cold, Common Cold, Cough, Cough caused by Common Cold, Coughing caused by Flu caused by Influenza, Dyskinesia of the Biliary Tract, Dyskinesia of the Urinary Tract, Febrile Convulsions, Febrile Illness Acute, Fever, Fibromyalgia, Flu caused by Influenza, Headache, Joint dislocations, Menstrual Distress (Dysmenorrhea), Mild pain, Muscle Inflammation, Muscle Injuries, Muscle Spasms, Musculoskeletal Pain, Myalgia, Nasal Congestion, Neuropathic Pain, Osteoarthritis (OA), Pain, Postoperative pain, Premenstrual cramps, Rheumatoid Arthritis, Rhinopharyngitis, Rhinorrhoea, Severe Pain, Sinusitis, Spasms, Spastic Pain of the Gastrointestinal Tract, Sprains, Symptoms Cold, Tension Headache, Toothache, Upper Respiratory Tract Infection, Whiplash Syndrome, Acute Torticollis, Articular inflammation, Cold or flu syndrome, Mild to moderate pain, Minor aches and pains, Minor pain, Moderate Pain, Moderate to severe pain
Associated Therapies
Airway secretion clearance therapy, Anti-spasmodics, Bronchodilation

Prevention of Post-Operative Shivering

First Posted Date
2020-12-24
Last Posted Date
2022-03-31
Lead Sponsor
Cairo University
Target Recruit Count
120
Registration Number
NCT04682743
Locations
🇪🇬

Cairo university, Cairo, Egypt

Oral Versus Intravenous Acetaminophen for Postoperative Pain Control

Not Applicable
Terminated
Conditions
Interventions
First Posted Date
2020-12-10
Last Posted Date
2022-11-30
Lead Sponsor
Northwell Health
Target Recruit Count
42
Registration Number
NCT04662567
Locations
🇺🇸

Northwell Fertility Center #3816, Manhasset, New York, United States

An Evaluation of Pain Outcomes of Ketorolac Administration in Children Undergoing Circumcision

First Posted Date
2020-11-30
Last Posted Date
2024-08-02
Lead Sponsor
Alberta Children's Hospital
Target Recruit Count
100
Registration Number
NCT04646967
Locations
🇨🇦

Alberta Children's Hospital, Calgary, Alberta, Canada

A Study Evaluating the Efficacy and Safety of Obinutuzumab in Participants With Primary Membranous Nephropathy

First Posted Date
2020-11-16
Last Posted Date
2024-08-22
Lead Sponsor
Hoffmann-La Roche
Target Recruit Count
140
Registration Number
NCT04629248
Locations
🇺🇦

Regional Clinical Hospital n.a I.I. Mechnicov, Dnipropetrovsk, Ukraine

🇺🇦

Ternopil University Hospital, Ternopil, Kherson Governorate, Ukraine

🇺🇸

Nephrotex Research Group, Dallas, Texas, United States

and more 52 locations

Ibuprofen Plus Acetaminophen for Enhanced Pain Reduction

First Posted Date
2020-11-16
Last Posted Date
2022-04-14
Lead Sponsor
New York City Health and Hospitals Corporation
Target Recruit Count
100
Registration Number
NCT04630834
Locations
🇺🇸

Jacobi Medical Center, Bronx, New York, United States

Magnesium Oral Supplementation for Acute Non-specific Low Back Pain

Not Applicable
Completed
Conditions
Interventions
First Posted Date
2020-11-12
Last Posted Date
2020-11-12
Lead Sponsor
Istanbul University
Target Recruit Count
240
Registration Number
NCT04626063
Locations
🇹🇷

Istanbul University Istanbul Faculty of Medicine, Istanbul, Fatih, Turkey

Effect of Premedicant Oral Paracetamol on Gastric Volume and pH

Phase 4
Conditions
Interventions
First Posted Date
2020-11-12
Last Posted Date
2021-02-21
Lead Sponsor
King's College Hospital NHS Trust
Target Recruit Count
104
Registration Number
NCT04625608
Locations
🇬🇧

King's College Hospital, London, United Kingdom

Paracetamol, Dexketoprofen and Ibuprofen In Non-Traumatic Acute Low Back Pain

First Posted Date
2020-10-30
Last Posted Date
2020-10-30
Lead Sponsor
Pamukkale University
Target Recruit Count
210
Registration Number
NCT04609254
Locations
🇹🇷

Pamukkale University, Denizli, Turkey

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