Acetaminophen

Generic Name
Acetaminophen
Brand Names
Acephen, Acetadryl, Allzital, Apadaz, Arthriten Inflammatory Pain, Bupap, Butapap, Cetafen, Children's Silapap, Coricidin Hbp Cold & Flu, Darvocet-N, Dayquil Sinex, Diphen, Dolofin, Dologen, Dologesic Reformulated Jun 2016, Duralgina, Dvorah, Endocet, Esgic, Exaprin, Excedrin, Excedrin PM Triple Action, Excedrin Tension Headache, Feverall, Fioricet, Fioricet With Codeine, Goody's Back & Body Pain Relief, Goody's Body Pain, Goody's Extra Strength, Goody's Headache Relief Shot, Goody's PM, Hycet, Legatrin PM, Little Fevers, Lorcet, Lortab, Mapap, Mersyndol, Midol Complete, Midol Cramps & Bodyaches, Nalocet, Norco, Orbivan, Pamprin Max Formula, Pamprin Multi-symptom, Panadol, Pediacare Children's Fever Reducer Pain Reliever, Percocet, Percogesic Reformulated Jan 2011, Pharbetol, Premsyn Pms, Prolate, Rivacocet, Robaxacet, Robaxacet-8, Roxicet, Sudafed PE Sinus Headache, Tactinal, Tencon, Trezix, Triatec, Triatec-30, Triatec-8, Tylenol, Tylenol PM, Tylenol With Codeine, Ultracet, Vanatol, Vanatol S, Vanquish, Xodol, Xolox, Zamicet, Zflex, Zydone
Drug Type
Small Molecule
Chemical Formula
C8H9NO2
CAS Number
103-90-2
Unique Ingredient Identifier
362O9ITL9D
Background

Acetaminophen (paracetamol), also commonly known as Tylenol, is the most commonly taken analgesic worldwide and is recommended as first-line therapy in pain conditions by the World Health Organization (WHO). It is also used for its antipyretic effects, helping to reduce fever. This drug was initially approved by the U.S. FDA in 1951 and is available in a variety of forms including syrup form, regular tablets, effervescent tablets, injection, suppository, and other forms.

Acetaminophen is often found combined with other drugs in more than 600 over the counter (OTC) allergy medications, cold medications, sleep medications, pain relievers, and other products. Confusion about dosing of this drug may be caused by the availability of different formulas, strengths, and dosage instructions for children of different ages. Due to the possibility of fatal overdose and liver failure associated with the incorrect use of acetaminophen, it is important to follow current and available national and manufacturer dosing guidelines while this drug is taken or prescribed.

Indication

In general, acetaminophen is used for the treatment of mild to moderate pain and reduction of fever. It is available over the counter in various forms, the most common being oral forms.

Acetaminophen injection is indicated for the management of mild to moderate pain, the management of moderate to severe pain with adjunctive opioid analgesics, and the reduction of fever.

Because of its low risk of causing allergic reactions, this drug can be administered in patients who are intolerant to salicylates and those with allergic tendencies, including bronchial asthmatics. Specific dosing guidelines should be followed when administering acetaminophen to children.

Associated Conditions
Acute Gouty Arthritis, Acute Musculoskeletal Pain, Allergic Reaction, Allergy to Tree Pollen, Ankylosing Spondylitis (AS), Chills, Cold, Common Cold, Cough, Cough caused by Common Cold, Coughing caused by Flu caused by Influenza, Dyskinesia of the Biliary Tract, Dyskinesia of the Urinary Tract, Febrile Convulsions, Febrile Illness Acute, Fever, Fibromyalgia, Flu caused by Influenza, Headache, Joint dislocations, Menstrual Distress (Dysmenorrhea), Mild pain, Muscle Inflammation, Muscle Injuries, Muscle Spasms, Musculoskeletal Pain, Myalgia, Nasal Congestion, Neuropathic Pain, Osteoarthritis (OA), Pain, Postoperative pain, Premenstrual cramps, Rheumatoid Arthritis, Rhinopharyngitis, Rhinorrhoea, Severe Pain, Sinusitis, Spasms, Spastic Pain of the Gastrointestinal Tract, Sprains, Symptoms Cold, Tension Headache, Toothache, Upper Respiratory Tract Infection, Whiplash Syndrome, Acute Torticollis, Articular inflammation, Cold or flu syndrome, Mild to moderate pain, Minor aches and pains, Minor pain, Moderate Pain, Moderate to severe pain
Associated Therapies
Airway secretion clearance therapy, Anti-spasmodics, Bronchodilation

PAracetamol Treatment in Hypertension: Effect on Blood Pressure (PATH-BP) Study

Phase 4
Completed
Conditions
Interventions
First Posted Date
2013-11-27
Last Posted Date
2019-10-02
Lead Sponsor
University of Edinburgh
Target Recruit Count
100
Registration Number
NCT01997112
Locations
🇬🇧

Clinical Research Centre, Western General Hospital, Edinburgh, City Of Edinburgh, United Kingdom

Nonsteroidal Antiinflammatory Drugs in Women With Postpartum Pre-eclampsia

Phase 2
Completed
Conditions
Interventions
First Posted Date
2013-11-20
Last Posted Date
2015-07-28
Lead Sponsor
Complejo Hospitalario Dr. Arnulfo Arias Madrid
Target Recruit Count
114
Registration Number
NCT01988298
Locations
🇵🇦

Paulino Vigil-De Gracia, Panamá, Panama

Multimodal Analgesic Treatment Versus Traditional Morphine Analgesia After Cardiac Surgery

First Posted Date
2013-10-21
Last Posted Date
2013-10-21
Lead Sponsor
Rigshospitalet, Denmark
Target Recruit Count
180
Registration Number
NCT01966172
Locations
🇩🇰

Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark

Study of Efficacy and Safety of Tinospora Crispa-extract Product Compared With the Acetaminophen

First Posted Date
2013-10-09
Last Posted Date
2015-03-11
Lead Sponsor
Chulalongkorn University
Target Recruit Count
96
Registration Number
NCT01958866
Locations
🇹🇭

Pornanong Aramwit, Bangkok, Thailand

The Effect of Dexamethasone in Combination With Paracetamol and Ibuprofen on Postoperative Pain After Spine Surgery

First Posted Date
2013-10-01
Last Posted Date
2015-10-27
Lead Sponsor
Rigshospitalet, Denmark
Target Recruit Count
160
Registration Number
NCT01953978
Locations
🇩🇰

Glostrup University Hospital, Glostrup, Denmark

Pain and Suction Curettage

First Posted Date
2013-09-20
Last Posted Date
2013-09-20
Lead Sponsor
Gökhan Açmaz
Target Recruit Count
111
Registration Number
NCT01947205
Locations
🇹🇷

Kayseri Education and Research Hospital of Medicine, Kayseri, Turkey

Percutaneous Pin Removal in Children - is Analgesia Necessary?

Not Applicable
Completed
Conditions
Interventions
First Posted Date
2013-09-17
Last Posted Date
2013-09-17
Lead Sponsor
KK Women's and Children's Hospital
Target Recruit Count
240
Registration Number
NCT01944085
Locations
🇸🇬

KK Women's & Children's Hospital, Singapore, Singapore

The Preterm Infants' Paracetamol Study

First Posted Date
2013-09-10
Last Posted Date
2024-10-18
Lead Sponsor
University of Oulu
Target Recruit Count
120
Registration Number
NCT01938261
Locations
🇫🇮

Department of Pediatrics, Oulu University Hospital, Oulu, Finland

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